1. Effect of fish and olive oil on mitochondrial ATPase activity and membrane fluidity in patients with relapsing-remitting multiple sclerosis treated with interferon beta 1-b.
- Author
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Torres-Sánchez ED, Pacheco-Moisés FP, Macias-Islas MA, Morales-Sánchez EW, Ramírez-Ramírez V, Celis de la Rosa AJ, Cid-Hernández M, Sorto-Gómez TE, and Ortiz GG
- Subjects
- Adult, Dietary Supplements, Double-Blind Method, Female, Humans, Male, Membrane Fluidity drug effects, Middle Aged, Mitochondria drug effects, Adenosine Triphosphatases metabolism, Fish Oils pharmacology, Interferon-beta therapeutic use, Mitochondria enzymology, Multiple Sclerosis, Relapsing-Remitting drug therapy, Multiple Sclerosis, Relapsing-Remitting enzymology, Olive Oil pharmacology
- Abstract
Background: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated with increased oxidative stress (OS) and mitochondrial alterations. Fish oil consumption has neuroprotective, antioxidant and anti-inflammatory effects in patients with relapsing-recurrent MS (RR-MS)., Objective: To evaluate changes in the hydrolytic activity of ATP synthase and mitochondrial membrane fluidity in patients with RR-MS who receive fish oil or olive oil as a dietary supplement., Methods: Clinical, controlled, randomized, double-blind trial. Patients consumed fish oil or olive oil for one year. The hydrolytic activity of ATPase and the fluidity of the mitochondrial membrane of platelets were quantified., Results: In patients with RR-MS, a decrease in the fluidity of mitochondrial membranes and an increase in the hydrolytic activity of ATP synthase was observed in comparison with healthy controls. After 6 or 9 months of treatment with fish oil or olive oil, respectively, these values were normalized., Conclusion: The consumption of fish oil and olive oil increases the fluidity of the mitochondrial membranes and decreases the catabolic activity of ATP synthase in platelets from patients with RR-MS.
- Published
- 2018
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