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Metastasis in retroperitoneal lymph nodes is found to be relatively chemoresistant according to various studies. The role of systematic lymphadenectomy in advanced epithelial ovarian cancer is a controversial topic. The aim of this study is to determine the rate of lymph node positivity in patients undergoing interval cytoreduction in epithelial ovarian cancer and its effect on recurrence-free and overall survival. Retrospective study of 60 patients with advanced epithelial ovarian cancer who underwent interval cytoreduction between January 2011 and December 2015 was done. The histopathology report was studied, and the percentage of nodal metastases was determined. The overall survival and recurrence-free survival were calculated. The association of node positivity to survival and recurrence pattern was analyzed. Our study found that the rate of lymph node positivity was 25%, and this was comparable to other studies. The median recurrence-free survival (RFS) for all patients was 24.4 months. RFS for node-positive patients was 15.7 and 26.8 months for node-negative patients (p-value 0.002). The Median overall survival for all patients was 73.6 months. The mean overall survival (OS) for patients with positive nodes was 49.9 and 51 months and for patients with negative nodes (p-value 0.492). Lymph nodes are relatively chemoresistant. The presence of nodal metastases has a significant impact on recurrence-free survival. However, its role in overall survival is not established. Systematic lymphadenectomy has prognostic implication in advanced epithelial ovarian cancer.

Papillary carcinoma of thyroid is the most common type among the thyroid cancers. The usual presentation is with asymptomatic swelling in front of the neck. These types of cancers may spread to the regional lymph nodes. Distant metastasis occurs usually in lung and bone. Although differentiated thyroid cancers may show microscopic vascular invasion, tumour thrombus into great veins is a rare phenomenon. We report a case of papillary carcinoma thyroid with a recurrence in thyroid bed associated with nodal metastasis and tumour thrombus in the great veins. Only few cases are reported with thyroid carcinoma with thrombus in vessels.

Squamous cell carcinoma of lip is a common malignancy in Indian subcontinent. Metastatic spread is infrequent. Although advanced tumours spread to lymph nodes in the neck, it does not typically present with lung metastasis or with lymphangitic carcinomatosis. We describe a patient who developed cough and increasing dyspnoea while on treatment for carcinoma of lip. Chest x-ray and computed tomography were consistent with lymphangitic carcinomatosis. Lymphangitic carcinomatosis occurs with many different primary tumours and can rarely occur in oral cancers. This is the first report from carcinoma of lip.