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3. Three weekly versus weekly concurrent cisplatin: a matter of safety in head and neck cancer

Author

Marta Maddalo, Giulia Marvaso, Davide Tomasini, Luigi Spiazzi, Andrea Emanuele Guerini, Irene Turturici, Marianna Alessandra Gerardi, D. Alterio, Michela Buglione, Maria Cossu Rocca, Matteo Augugliaro, L. Costa, Mohssen Ansarin, Diana Greco, L. Pegurri, Stefano Maria Magrini, and Barbara Alicja Jereczek-Fossa

Subjects
inorganic chemicals, Cisplatin, Oncology, medicine.medical_specialty, business.industry, Internal medicine, Head and neck cancer, medicine, medicine.disease, business, neoplasms, female genital diseases and pregnancy complications, medicine.drug
Abstract

Background Radio-chemotherapy with CDDP is the standard for H&N squamous cell cancer. CDDP 100mg/m2/q3 is the standard; alternative schedules are used to reduce toxicity, mostly 40mg/m2/q1. Methods Patients were treated from 1/2010 to 1/2017 in two Radiation Oncology Centres. Propensity score analysis (PS) was retrospectively used to compare these two schedules. Results Patients analyzed were 166. Most (114/166) had 1w-CDDP while 52 had 3w-CDDP. In the 3w-CDDP group, patients were younger and with better performance status; disease extent was smaller and nodal involvement was more common than in the 1w-CDDP. Acute toxicity was similar in the groups. Treatment compliance was lower in the w-CCDP. OS before PS was better for female, for oropharyngeal disease and for 3w-CDDP group. After PS, survival was not related to the CDDP schedule. Conclusions 3w-CDDP remains the standard for fit patients, weekly schedule could be safely used in selected patients.

Published
2021
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4. PO-0961 Role of depth of infiltration (DOI) as independent prognostic factor in pT1--T2 N0 oral tongue SCC

Author

Barbara Alicja Jereczek-Fossa, Mohssen Ansarin, D. Alterio, Giuseppe Sanguineti, Alessia Farneti, Irene Turturici, Giulia Marvaso, Roberto Bruschini, Marta Tagliabue, P. D’urso, Stefania Volpe, S. Riccio, and Matteo Augugliaro

Subjects
Pathology, medicine.medical_specialty, Prognostic factor, Oncology, business.industry, Tongue SCC, medicine, Radiology, Nuclear Medicine and imaging, Hematology, medicine.disease, business, Infiltration (medical)
Published
2021
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5. PO-0845: Role of postoperative RT (PORT) after compartmental surgery for locally advanced oral cavity tumors

Author

Matteo Augugliaro, Mohssen Ansarin, Marta Tagliabue, Annamaria Ferrari, Irene Turturici, M.A. Zerella, Roberto Orecchia, O. Oneta, D. Alterio, Barbara Alicja Jereczek-Fossa, Giulia Marvaso, and Roberto Bruschini

Subjects
medicine.medical_specialty, Port (medical), Oncology, business.industry, Locally advanced, Medicine, Radiology, Nuclear Medicine and imaging, Hematology, Oral cavity, business, Surgery
Published
2020
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6. EP-1925 Association of MRI-based radiomic features with prognostic factors in oropharyngeal cancer

Author

Giulia Marvaso, Barbara Alicja Jereczek-Fossa, Mohssen Ansarin, Fausto Maffini, D. Alterio, Sara Raimondi, C. Delia, Caterina Giannitto, Massimo Bellomi, F. Botta, and Stefania Volpe

Subjects
Oncology, medicine.medical_specialty, business.industry, Association (object-oriented programming), Internal medicine, medicine, Cancer, Radiology, Nuclear Medicine and imaging, Hematology, medicine.disease, business
Published
2019
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7. EP-1160 Quantifying the impact of radiologic revision in head and neck cancer: monoinstitutional experience

Author

S. Arculeo, Barbara Alicja Jereczek-Fossa, Stefania Volpe, Giulia Marvaso, S. Durante, D. Alterio, A.F. Pounou Kamga, Roberto Orecchia, Irene Turturici, Lorenzo Preda, Mohssen Ansarin, Massimo Bellomi, M. Atac, Giulia Riva, Caterina Giannitto, Annamaria Ferrari, Gioacchino Giugliano, and M. Cossu Rocca

Subjects
medicine.medical_specialty, Oncology, business.industry, Head and neck cancer, medicine, Radiology, Nuclear Medicine and imaging, Hematology, Radiology, medicine.disease, business
Published
2019
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8. PO-0699: Weight loss in head and neck cancer: proof of concept for a stepped-wedge nutritional protocol

Author

Stefania Volpe, D. Alterio, Annarita Sabbatini, Mohssen Ansarin, Giulia Marvaso, Emanuela Zagallo, B.A. Jereczek Fossa, Annamaria Ferrari, Filippo Valoriani, Giuseppe Fanetti, and M. Cossu Rocca

Subjects
medicine.medical_specialty, business.industry, Head and neck cancer, Hematology, medicine.disease, Surgery, Oncology, Proof of concept, Weight loss, medicine, Stepped wedge, Radiology, Nuclear Medicine and imaging, medicine.symptom, business
Published
2018
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9. EP-1625: Cyberknife Radiosurgery On Brain Metastases From Melanoma In The Era Of Systemic Target Therapy

Author

Barbara Alicja Jereczek-Fossa, Giulia Marvaso, D. Alterio, Annamaria Ferrari, E. Cocorocchio, Giuseppe Fanetti, Elena Rondi, S. Vigorito, D. Sibio, C. Francia, and L. Pala

Subjects
medicine.medical_specialty, Oncology, business.industry, Melanoma, medicine, Radiology, Nuclear Medicine and imaging, Hematology, Target therapy, Radiology, CyberKnife Radiosurgery, medicine.disease, business
Published
2018
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10. PO-078 Radio-chemotherapy for Heand and Neck cancer: retrospective comparison between weekly and three-weekly CDDP

Author

Michela Buglione, Davide Tomasini, A. Alghisi, Roberto Orecchia, Marianna Alessandra Gerardi, D. Alterio, M. Cossu Rocca, Barbara Alicja Jereczek-Fossa, Stefano Maria Magrini, L. Costa, Marta Maddalo, Matteo Augugliaro, Annamaria Ferrari, Giulia Marvaso, Marco Lorenzo Bonù, and Diana Greco

Subjects
Oncology, medicine.medical_specialty, business.industry, Internal medicine, medicine, Cancer, Radiology, Nuclear Medicine and imaging, Hematology, business, medicine.disease, Radio chemotherapy
Published
2019
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11. PO-084 Quantification of the impact of radiologic imaging revision in Head and Neck cancer

Author

Caterina Giannitto, Massimo Bellomi, D. Alterio, Giulia Riva, A.F.K. Pounou, Roberto Orecchia, Mohssen Ansarin, Barbara Alicja Jereczek-Fossa, M. Cossu Rocca, Giulia Marvaso, G. Giuliano, S. Durante, Stefania Volpe, M. Atac, S. Arculeo, Irene Turturici, Lorenzo Preda, and Annamaria Ferrari

Subjects
medicine.medical_specialty, Oncology, business.industry, Head and neck cancer, medicine, Radiology, Nuclear Medicine and imaging, Hematology, Radiology, medicine.disease, business
Published
2019
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12. EP-1077: Predictive modeling for radiation-induced acute dysphagia in head and neck cancer patients

Author

Marianna Alessandra Gerardi, Annamaria Ferrari, Delia Ciardo, Elena Rondi, Matteo Muto, Vittoria D’Avino, Roberto Orecchia, Roberto Pacelli, B. Jereczek, Giuseppe Palma, D. Alterio, R. Spoto, and Laura Cella

Subjects
medicine.medical_specialty, Oncology, business.industry, Head and neck cancer, medicine, Radiology, Nuclear Medicine and imaging, Radiation induced, Hematology, Radiology, medicine.symptom, medicine.disease, business, Dysphagia
Published
2017
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13. Contents Vol. 74, 2008

Author

Goetz von Wichert, Dong Wook Shin, Bin Zhou, Hai-Yi Liu, J. Fiore, Giario Conti, Bing Xu, Lie Yang, Sergio Ricci, Kenji Sugamura, Zhengmei Yang, Stefan Breitenstein, Yong Chul Kwon, Davide Radice, Franco Nolè, Sang Yoon Park, Stefan Bierer, Stefan Dold, I. Floriani, Edwin Herrmann, Hidenori Akaike, Yoshiki Mizukami, Yuan Li, M. Medici, Bernhard C. Pestalozzi, Xiao-Gang Shen, Christoph Renner, Bonnie L. Hylander, Koji Kono, Joo-Hyun Nam, C. Marenghi, C. Codecà, F. Gray, M. Polivka, John F. Gibbs, Lothar Hertle, Masaharu Kasai, Quanhai Li, Yu-Fei Jiao, Alan Belicha-Villanueva, Osamu Muto, Laura Adamoli, Kohei Shitara, Chiara Catania, P. Bertheau, J.-M. Molina, Antonio Manganelli, Alessandra Rubagotti, Youquan Bu, D. Ferrari, Peter Kestenholz, Thomas Seufferlein, Elena Verri, Kousaku Mimura, L. Calabrese, Hamdy A. Azim, Chris Andrews, J.-B. Thiebault, Thomas Köpke, Frank Stenner-Liewen, Alberto Lapini, Zong-Guang Zhou, D. Alterio, Panagiotis Samaras, Francesco Boccardo, Noriyuki Yamada, Hidemitsu Sugai, M. Lagrange-Xelot, Julia Braun, Yuh Sakata, P. Foa, Jun-Min Song, Xiao-Feng Sun, Christian Wülfing, Giorgio Cruciani, Sang Min Park, Tamotsu Sugai, Young Ho Yun, Guido Adler, F. Chiesa, Yoshihiko Kawaguchi, Chong Taik Park, Filippo de Braud, Wataru Habano, B. Zuber, Volker Kaechele, Ling Wang, Hideki Fujii, B.A. Jereczek-Fossa, Yu-Jian Zeng, Elizabeth A. Repasky, Michele Battaglia, Fangzhou Song, Hatem A. Azim, Humberto Villavicencio, Aron Goldhirsch, Joachim Gerss, S. Gallien, A. Luciani, Alexander Imhof, Pablo Maroto Rey, Duk-Soo Bae, Jong Min Lee, Rong Wang, Shin-ichi Nakamura, R. Orecchia, Chi-Heum Cho, Tommaso De Pas, and Masaki Munakata

Subjects
Cancer Research, Oncology, General Medicine
Published
2008
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14. PO-133: Occult lymphnode metastasis in early stage OPC treated with TORS without neck lymphnodes dissection

Author

D. Alterio, Gioacchino Giugliano, Giulia Marvaso, Barbara Alicja Jereczek-Fossa, Mohssen Ansarin, Alessandra Rappa, M. Cossu Rocca, D. Sibio, Annamaria Ferrari, Lorenzo Preda, C. Francia, Stefano Zorzi, and Fausto Maffini

Subjects
medicine.medical_specialty, Oncology, business.industry, medicine, Radiology, Nuclear Medicine and imaging, Hematology, Dissection (medical), Stage (cooking), medicine.disease, business, Occult, Surgery, Metastasis
Published
2017
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15. EP-1719: Radiobiology based head & neck cancer protocol (FAMOSO) combining accelerated RT and EGFr inhibitor

Author

Elena Rondi, Mahila Ferrari, Lidia Strigari, Marta Cremonesi, Piernicola Pedicini, S. Vigorito, F. Botta, Annamaria Ferrari, Federica Cattani, Cristina Garibaldi, M. Cossu Rocca, Roberto Orecchia, D. Alterio, and Barbara Alicja Jereczek-Fossa

Subjects
Oncology, medicine.medical_specialty, Radiobiology, Radiology Nuclear Medicine and imaging, business.industry, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, Hematology, Head neck cancer, business, EGFR inhibitors
Published
2016
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16. 2830 A combined modality treatment with primary chemotherapy followed by Transoral Laser Microsurgery in intermediate stage laryngeal squamous cell carcinoma: A phase II study

Author

Franco Nolè, Daniela Lepanto, Roberto Iacovelli, Fausto Maffini, Susanna Chiocca, Lorenzo Preda, Gaetano Aurilio, Marta Tagliabue, L. DeBenedetto, M A Massaro, D. Cullurà, D. Alterio, Augusto Cattaneo, M. Cossu Rocca, Luigi Santoro, Mohssen Ansarin, and Elena Verri

Subjects
Oncology, Cancer Research, medicine.medical_specialty, business.industry, Phases of clinical research, Combined modality treatment, Laryngeal squamous cell carcinoma, Intermediate stage, Internal medicine, medicine, Primary chemotherapy, Radiology, Transoral laser microsurgery, business
Published
2015
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17. PO-058: Primary chemotherapy followed by Transoral Laser Microsurgery and early laryngeal squamous cell carcinoma

Author

Augusto Cattaneo, M. Cossu Rocca, Susanna Chiocca, Luigi Santoro, Lorenzo Preda, Elena Verri, Fausto Maffini, M A Massaro, D. Alterio, and Mohssen Ansarin

Subjects
Oncology, medicine.medical_specialty, business.industry, Internal medicine, Medicine, Radiology, Nuclear Medicine and imaging, Primary chemotherapy, Hematology, Transoral laser microsurgery, Radiology, business, Laryngeal squamous cell carcinoma
Published
2015
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18. Subject Index Vol. 74, 2008

Author

Hatem A. Azim, Osamu Muto, B.A. Jereczek-Fossa, Panagiotis Samaras, Bernhard C. Pestalozzi, Duk-Soo Bae, Noriyuki Yamada, Xiao-Gang Shen, C. Marenghi, Hai-Yi Liu, Francesco Boccardo, J.-B. Thiebault, Yuh Sakata, Lothar Hertle, Christoph Renner, Quanhai Li, Aron Goldhirsch, Shin-ichi Nakamura, M. Lagrange-Xelot, Jun-Min Song, Giario Conti, Lie Yang, Jong Min Lee, Xiao-Feng Sun, Zhengmei Yang, Hamdy A. Azim, Volker Kaechele, Rong Wang, Antonio Manganelli, Bing Xu, A. Luciani, Bin Zhou, J. Fiore, Alberto Lapini, Pablo Maroto Rey, R. Orecchia, Youquan Bu, Yuan Li, Kenji Sugamura, Bonnie L. Hylander, Christian Wülfing, Yu-Jian Zeng, Chris Andrews, I. Floriani, Hidenori Akaike, Alexander Imhof, Edwin Herrmann, Guido Adler, Chi-Heum Cho, Elizabeth A. Repasky, Michele Battaglia, Masaharu Kasai, Tommaso De Pas, Sang Min Park, Kohei Shitara, Fangzhou Song, Hideki Fujii, Julia Braun, D. Ferrari, Chiara Catania, Elena Verri, Humberto Villavicencio, Yoshihiko Kawaguchi, Davide Radice, Young Ho Yun, Wataru Habano, B. Zuber, F. Chiesa, Goetz von Wichert, Ling Wang, Chong Taik Park, Stefan Dold, M. Polivka, John F. Gibbs, Yoshiki Mizukami, Joachim Gerss, S. Gallien, F. Gray, Alan Belicha-Villanueva, Joo-Hyun Nam, Yu-Fei Jiao, Dong Wook Shin, Yong Chul Kwon, Sergio Ricci, Franco Nolè, Sang Yoon Park, Thomas Köpke, Frank Stenner-Liewen, Kousaku Mimura, D. Alterio, Filippo de Braud, Hidemitsu Sugai, Thomas Seufferlein, C. Codecà, Laura Adamoli, P. Bertheau, Alessandra Rubagotti, Tamotsu Sugai, Stefan Bierer, M. Medici, Peter Kestenholz, Zong-Guang Zhou, J.-M. Molina, L. Calabrese, Stefan Breitenstein, Koji Kono, Masaki Munakata, P. Foa, and Giorgio Cruciani

Subjects
Cancer Research, Index (economics), Oncology, Statistics, Subject (documents), General Medicine, Mathematics
Published
2008
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19. EP-1085: EGFR expression in head and neck cancer : does it have a role as prognostic factor in radiotherapy?

Author

Giulia Marvaso, Mohssen Ansarin, M. Cossu Rocca, D. Alterio, Dario Zerini, Roberto Orecchia, Samantha Dicuonzo, Cristiana Fodor, Matteo Muto, Fausto Maffini, Annamaria Ferrari, B. Jereczek-Fossal, Susanna Chiocca, and Luigi Santoro

Subjects
Oncology, medicine.medical_specialty, Prognostic factor, business.industry, medicine.medical_treatment, Head and neck cancer, Hematology, medicine.disease, Egfr expression, Radiation therapy, Radiology Nuclear Medicine and imaging, Internal medicine, Medicine, Radiology, Nuclear Medicine and imaging, business
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20. High CXCR4 Expression Correlates with Sunitinib Poor Response in Metastatic Renal Cancer

Author

Giacomo Cartenì, A. La Mura, S. Perdonà, Luigi Portella, Crescenzo D'Alterio, Sandro Pignata, Gaetano Facchini, Oscar Nappi, G. Di Lorenzo, Stefania Scala, Riccardo Autorino, Renato Franco, Giuseppe Castello, Alessandro Ottaiano, Mino Rizzo, D' Alterio, C, Portella, L, Ottaiano, A, Rizzo, M, Carteni, G, Pignata, S, Facchini, G, Perdona, S, Di Lorenzo, G, Autorino, Riccardo, Franco, Renato, La Mura, A, Nappi, O, Castello, G, and Scala, S.

Subjects
Male, Oncology, Cancer Research, Pathology, Indoles, Time Factors, Angiogenesis Inhibitors, Kaplan-Meier Estimate, urologic and male genital diseases, CXCR4, Risk Factors, Drug Discovery, Sunitinib, Aged, 80 and over, Middle Aged, Immunohistochemistry, Kidney Neoplasms, Treatment Outcome, Italy, Predictive value of tests, Female, medicine.drug, Adult, Receptors, CXCR4, medicine.medical_specialty, Risk Assessment, Disease-Free Survival, Predictive Value of Tests, Cell Line, Tumor, Internal medicine, Biomarkers, Tumor, medicine, Carcinoma, Humans, Pyrroles, RNA, Messenger, Carcinoma, Renal Cell, Grading (tumors), Aged, Proportional Hazards Models, Pharmacology, Chi-Square Distribution, Proportional hazards model, business.industry, medicine.disease, Concomitant, Multivariate Analysis, Neoplasm Grading, business
Abstract

Background: Almost 30% of the sunitinib-treated patients for metastatic renal carcinoma (mRCC) do not receive a clinical benefit. Convincing evidences demonstrated a cross talk between the VEGF and CXCR4 pathways. It was hypothesized that CXCR4 expression in primary renal cancer could predict sunitinib responsiveness. Patients and Methods: In this exploratory study sixty-two mRCC patients receiving sunitinib as first-line treatment were evaluated for CXCR4 expression through immunohistochemistry (IHC). Correlations between CXCR4 expression, baseline patients and tumour characteristics were studied by contingency tables and the chi-square test. Univariable analysis was performed with the log-rank test, and the Cox model was applied for multivariable analysis. Results: The objective response rate of sunitinib first-line therapy was 35.5% (22/62) with a disease control rate (response and stable disease) of 62.9% (39/62). CXCR4 expression was absent/low in 30 (48.4%), moderate in 17 (27.4%), and high in 15 (24.2%) tumors respectively. Low or absent CXCR4 expression predicted response to sunitinib therapy. Moreover, Fuhrman grading and concomitant, CXCR4 and Fuhrman grading, strongly predicted sunitinib first line therapy responsiveness on progression-free survival and overall survival. Conclusions: High CXCR4 expression correlates with sunitinib poor response in metastatic renal cancer

Published
2012
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