19 results on '"Gupta, Abha"'
Search Results
2. Loneliness among adolescents and young adults with cancer during the COVID-19 pandemic: a cross-sectional survey
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Howden, Kaitlyn, Yan, Adam P., Glidden, Camille, Romanescu, Razvan G., Scott, Ian, Deleemans, Julie M., Chalifour, Karine, Eaton, Geoff, Gupta, Abha A., Bolton, James M., Garland, Sheila N., Mahar, Alyson L., and Oberoi, Sapna
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- 2022
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3. Adapting an Adolescent and Young Adult Program Housed in a Quaternary Cancer Centre to a Regional Cancer Centre: Creating Equitable Access to Developmentally Tailored Support.
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Smith, Marlie, Kurup, Simone, Devaraja, Kaviya, Shanawaz, Shaayini, Reynolds, Lorrie, Ross, Jill, Bezjak, Andrea, Gupta, Abha A., and Kassam, Alisha
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YOUNG adults ,TEENAGERS ,SOCIAL impact ,SOCIAL support ,ONCOLOGY nursing ,COMMUNITY-based programs - Abstract
Adolescents and young adults (AYAs) with cancer, representing those between 15 and 39 years of age, face distinctive challenges balancing their life stage with the physical, emotional, and social impacts of a cancer diagnosis. These challenges include fertility concerns, disruptions to educational and occupational pursuits, issues related to body image and sexual health, and the need for age-appropriate psychosocial support within their communities. The Princess Margaret Cancer Centre (PM), a quaternary care center, established a specialized AYA program in 2014, offering holistic and developmentally tailored psychosocial support and currently, efforts are underway to expand this to other regions in the province to address the need for equitable access. The establishment process involves securing funding, conducting an environmental scan, identifying service gaps, developing clinical pathways, and implementing AYA supportive care. An accessible AYA program should also consider social determinants of health, social location, intersectionality, and an interdisciplinary health approach in understanding health inequities in AYA oncology care. This paper describes the processes implemented and challenges faced in creating a community-based AYA program beyond major resource-rich cities and efforts to address intersectionality. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Advanced Cancer in Young Adults (YAs): Living in a Liminal Space.
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Avery, Jonathan, Campbell, Kristin L., Mosher, Pamela, Al-Awamer, Ahmed, Goddard, Karen, Edwards, Annemarie, Burnett, Laura, Hannon, Breffni, Gupta, Abha, and Howard, A. Fuchsia
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TUMOR diagnosis ,DISEASE progression ,COMPUTER software ,SPECIALTY hospitals ,SOCIAL constructionism ,GROUNDED theory ,RESEARCH methodology ,FUNCTIONAL status ,PATIENT decision making ,ACHIEVEMENT ,ACTIVITIES of daily living ,INTERVIEWING ,MENTAL health ,UNCERTAINTY ,PATIENTS' attitudes ,CANCER treatment ,TREATMENT effectiveness ,HOPE ,DIARY (Literary form) ,COMMUNICATION ,FIELD notes (Science) ,RESEARCH funding ,DEATH ,STATISTICAL sampling ,JUDGMENT sampling ,PSYCHOLOGICAL adaptation ,DATA analysis ,DATA analysis software ,ONCOLOGISTS ,CANCER patient medical care ,GOAL (Psychology) ,PROMPTS (Psychology) ,ADULTS - Abstract
Young adults (YAs), defined as individuals between the ages of 18 and 39 years, experience unique challenges when diagnosed with advanced cancer. Using the social constructivist grounded theory approach, we aimed to develop a theoretical understanding of how YAs live day to day with their diagnosis. A sample of 25 YAs (aged 22–39 years) with advanced cancer from across Canada participated in semi-structured interviews. Findings illustrate that the YAs described day-to-day life as an oscillating experience swinging between two opposing disease outcomes: (1) hoping for a cure and (2) facing the possibility of premature death. Oscillating between these potential outcomes was characterized as living in a liminal space wherein participants were unsure how to live from one day to the next. The participants oscillated at various rates, with different factors influencing the rate of oscillation, including inconsistent and poor messaging from their oncologists or treatment team, progression or regression of their cancer, and changes in their physical functioning and mental health. These findings provide a theoretical framework for designing interventions to help YAs adapt to their circumstance. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Adolescent and young adult (AYA) oncology: A credentialed area of focused competence in Canada.
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Srikanthan, Amirrtha, Karpinski, Jolanta, and Gupta, Abha
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YOUNG adults ,TEENAGERS ,EDUCATIONAL standards ,ONCOLOGY ,TASK forces ,AGE factors in cancer - Abstract
Background: Adolescents and young adults (AYA, ages 15–39 years) affected by cancer have unique treatment, survivorship, and palliation concerns. Current oncology training does not focus on the distinctive needs of this demographic. Amid this recognition, the Canadian National AYA Cancer Task Force and Canadian Partnership Against Cancer have advocated the need for clinicians with formalized AYA experience. To address this need and standardize training, a national task force developed criteria for structured academic programs in AYA Oncology in Canada. Methods: Workshops were organized to identify and establish the fundamentals of practice in AYA Oncology through consensus. These workshops followed the pre‐existing rigorous process established by the Royal College of Physicians and Surgeons of Canada (Royal College) for new program development. The process includes: (i) developing the tasks associated with the discipline's practice, (ii) identifying the evidence trainees must provide to demonstrate tasks can be performed independently (the competence portfolio), (iii) developing training requirements and summarizing the knowledge, skills and attitudes required to perform these tasks, and (iv) identifying specific experiences essential to acquiring skills and demonstrating competent performance. Results: AYA Oncology is a recognized an Area of Focused Competence (AFC) by the Royal College. Conclusion: The AFC designation in AYA Oncology provides a standardized curriculum, training experience and accreditation process to attract oncologists, promote expertise and advance AYA oncology care. [ABSTRACT FROM AUTHOR]
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- 2023
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6. COVID-19-Related Information Sources, Behavioral Changes, and Adherence to Social Distancing Among Adolescents and Young Adults with Cancer.
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Yan, Adam P., Howden, Kaitlyn, Glidden, Camille, Romanescu, Razvan G., Scott, Ian, Deleemans, Julie M., Chalifour, Karine, Eaton, Geoff, Gupta, Abha A., Bolton, James M., Garland, Sheila N., Mahar, Alyson L., and Oberoi, Sapna
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MEDICAL masks ,UNEMPLOYMENT ,MULTIPLE regression analysis ,SOCIAL media ,MULTIVARIATE analysis ,CANCER patients ,SURVEYS ,SOCIOECONOMIC factors ,INFORMATION resources ,DESCRIPTIVE statistics ,NEWSPAPERS ,HEALTH ,PATIENT compliance ,SOCIAL distancing ,COVID-19 pandemic ,BEHAVIOR modification - Abstract
Purpose: This study aimed to assess the sources of COVID-19 information used, behavioral changes in response to the pandemic, and factors associated with adherence to social distancing guidelines among adolescents and young adults (AYAs) with cancer during the COVID-19 pandemic. Methods: We conducted a self-administered online survey of AYAs with cancer (aged 18–39 years) diagnosed between ages 15 and 39 and living in Canada during January and February 2021. Data were summarized using descriptive statistics. Multiple logistic regression was used to identify the factors associated with adherence to the social distancing guidelines. Results: In total, 805 AYAs were included. Participants were most likely to obtain COVID-19-related information from social media (60.5%), news reports (51.6%), and medical professionals (46.5%). The preferred modes of receiving information were websites of cancer organizations (47.9%), social media (44.8%), and medical professionals (40.2%). The common behavioral changes in response to the COVID-19 pandemic included wearing a protective mask (60.2%), avoiding crowded and public places (56.9%), and abiding by social distancing rules (49.4%). On multivariable analysis, participants were more likely to adhere to social distancing rules if they were women, unemployed or collecting disability/unemployment benefits, or had a personal income of <$40,000 in year 2020 (p < 0.05). Conclusion: Social media and websites of cancer organizations are the preferred modes of COVID-19 information. Since many AYAs are nonadherent to preventative health measures, cancer organizations should help develop and disseminate digital resources that provide tailored information to AYAs with cancer during this pandemic. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Assessing information and service needs of young adults with cancer at a single institution: the importance of information on cancer diagnosis, fertility preservation, diet, and exercise
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Gupta, Abha A., Edelstein, Kim, Albert-Green, Alisha, and D’Agostino, Norma
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- 2013
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8. The Transformation of Adolescent and Young Adult Oncological and Supportive Care in Canada: A Mixed Methods Study.
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Avery, Jonathan, Wong, Emily, Harris, Christine, Chapman, Stacy, Uppal, Serena, Shanawaz, Shaayini, Edwards, Annemarie, Burnett, Laura, Vora, Tushar, and Gupta, Abha A.
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ONCOLOGY ,YOUNG adults ,CANCER treatment ,MEDICAL care ,MIXED methods research - Abstract
Background: Due to ongoing disparity in the specialized care available to adolescents and young adults (AYAs) with cancer, this study aimed to understand the gaps and barriers to accessing care and preferences on types of solutions at a national Canadian level. Methods: A mixed-methods study involving an online survey and focus groups (FGs) was conducted among AYAs residing in different regions of Canada. Results: There were a total of 174 survey respondents, of whom the majority were between 30–39 years of age (n = 125, 71.8%). Of the 174 respondents, 36 (20.7%) participated in one of seven FGs. Triangulation of the results illustrated that AYAs are not appropriately informed about the long-term health risks of being treated for cancer and where/how to seek support. These results culminated into three themes: (1) the need for AYA relevant and timely information about health risks; by (a) producing health risk-related content with the AYA life stage in mind; (b) providing a guided "map" to help AYAs anticipate what they may experience, and (c) providing checklists to help AYAs navigate their experience; (2) need for tailored and timely supportive care including (a) establishing ongoing check-ins and (b) receiving navigation support, and (3) need for enhanced connections by creating (a) a space to gather, connect and seek mentorship and (b) a hub to access information. Conclusion: AYAs continue to lack sufficient support both during and following cancer and mechanisms are required to ensure longitudinal support is provided across jurisdictions and in all stages of the cancer journey. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Extra-Pleural Pneumonectomy (EPP) in Children and Adults with Locally Advanced Sarcoma: A CanSaRCC Study.
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Rodrigues, Caroline, Peretz Soroka, Hagit, Pierro, Agostino, Baertschiger, Reto M., Cypel, Marcelo, Donahoe, Laura, Tsang, Derek S., Cho, John, De Perrot, Marc, Waddell, Thomas K., and Gupta, Abha A.
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PNEUMONECTOMY ,SARCOMA ,PERICARDIUM ,CANCER patient care ,ONCOLOGY - Abstract
Simple Summary: Extra-pleural pneumonectomy (EPP) involves the removal of the parietal and visceral pleura, ipsilateral lungs, pericardium, and hemi diaphragm. In patients with advanced sarcoma in the pleura, EPP is often the only option for local control. The aim of our study was to review our institutional experience with EPP. Of ten patients in our study, five were alive without disease at last follow-up after multi-modality therapy including EPP. Two patients had local recurrence and died of progressive disease. One patient died of brain metastasis, one patient died of radiation induced sarcoma, and one patient died of surgical complications. Our results suggest that EPP is a feasible option for patients when used in combination with chemotherapy and radiation. Moreover, high-volume cancer centers should discuss the use of EPP during tumor board discussion. Sarcoma can present as locally advanced disease involving pleura for which extra-pleural pneumonectomy (EPP) may be the only surgical option to ensure adequate local control. Data were collected on patients who underwent EPP between January 2009 and August 2021 at Princess Margret Hospital and SickKids (Toronto) using the CanSaRCC (Canadian Sarcoma Research and Clinical Collaboration). Ten patients with locally advanced sarcoma involving the pleura, aged 4 to 59 years (median 19.5 years) underwent EPP. Nine (90%) received pre-operative chemotherapy and eight (80%) achieved an R0 resection. Hemithoracic radiation was administered preoperatively (n = 6, 60%) or postoperatively (n = 4, 40%). Five (50%) patients were alive without disease at last follow-up (median 34.2 months) and time from EPP to last FU was median 29.2 months (range 2.2–87.5). Two patients (20%) had local recurrence, 4.3 and 5.8 months from EPP, and both died from progressive disease, 13.1 and 8.2 months from EPP, respectively. One patient died from brain metastasis (17 months), one died from radiation associated osteosarcoma (66 months), and one died from surgical complications (heart failure from constrictive pericarditis). EPP offers a feasible and life-prolonging surgical consideration for patients with locally advanced sarcoma involving the pleura in combination with chemotherapy and radiation. Consequently, EPP should be considered during multi-disciplinary tumor board discussions at high-volume centers. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Association of Mindfulness-Based Interventions With Anxiety Severity in Adults With Cancer
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Oberoi, Sapna, Yang, Jiayu, Woodgate, Roberta L., Niraula, Saroj, Banerji, Shantanu, Israels, Sara J., Altman, Gary, Beattie, Sara, Rabbani, Rasheda, Askin, Nicole, Gupta, Abha, Sung, Lillian, Abou-Setta, Ahmed M., and Zarychanski, Ryan
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Adult ,Online Only ,Oncology ,Research ,Neoplasms ,Humans ,Anxiety ,Mindfulness ,Original Investigation ,Randomized Controlled Trials as Topic - Abstract
Key Points Question Are mindfulness-based interventions associated with decreased anxiety in adults with cancer? Findings In this systematic review and meta-analysis of 28 randomized clinical trials with 3053 participants, mindfulness-based interventions were associated with reductions in the severity of anxiety in adults with cancer up to 6 months after delivery of mindfulness sessions compared with usual care, waitlist control, or no intervention; a concomitant reduction in the severity of depression and improvement in health-related quality of life was also observed. None of the trials used mindfulness-based interventions in children with cancer. Meaning Mindfulness-based interventions were associated with a reduction in anxiety and depression in adults with cancer., This systematic review and meta-analysis of 28 randomized controlled trials examines the effectiveness in mindfulness-based interventions in reducing anxiety and depression in adult patients with cancer., Importance Mindfulness-based interventions (MBIs), grounded in mindfulness, focus on purposely paying attention to experiences occurring at the present moment without judgment. MBIs are increasingly used by patients with cancer for the reduction of anxiety, but it remains unclear if MBIs reduce anxiety in patients with cancer. Objective To evaluate the association of MBIs with reductions in the severity of anxiety in patients with cancer. Data Sources Systematic searches of MEDLINE, Embase, Cochrane Central Register of Controlled Trials, CINAHL, PsycINFO, and SCOPUS were conducted from database inception to May 2019 to identify relevant citations. Study Selection Randomized clinical trials (RCTs) that compared MBI with usual care, waitlist controls, or no intervention for the management of anxiety in cancer patients were included. Two reviewers conducted a blinded screening. Of 101 initially identified studies, 28 met the inclusion criteria. Data Extraction and Synthesis Two reviewers independently extracted the data. The Cochrane Collaboration risk-of-bias tool was used to assess the quality of RCTs, and the Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guideline was followed. Summary effect measures were reported as standardized mean differences (SMDs) and calculated using a random-effects model. Main Outcomes and Measures Our primary outcome was the measure of severity of short-term anxiety (up to 1-month postintervention); secondary outcomes were the severity of medium-term (1 to ≤6 months postintervention) and long-term (>6 to 12 months postintervention) anxiety, depression, and health-related quality of life of patients and caregivers. Results This meta-analysis included 28 RCTs enrolling 3053 adults with cancer. None of the trials were conducted in children. Mindfulness was associated with significant reductions in the severity of short-term anxiety (23 trials; 2339 participants; SMD, −0.51; 95% CI, −0.70 to −0.33; I2 = 76%). The association of mindfulness with short-term anxiety did not vary by evaluated patient, intervention, or study characteristics. Mindfulness was also associated with the reduction of medium-term anxiety (9 trials; 965 participants; SMD, −0.43; 95% CI, −0.68 to −0.18; I2 = 66%). No reduction in long-term anxiety was observed (2 trials; 403 participants; SMD, −0.02; 95% CI, −0.38 to 0.34; I2 = 68%). MBIs were associated with a reduction in the severity of depression in the short term (19 trials; 1874 participants; SMD, −0.73; 95% CI; −1.00 to −0.46; I2 = 86%) and the medium term (8 trials; 891 participants; SMD, −0.85; 95% CI, −1.35 to −0.35; I2 = 91%) and improved health-related quality of life in patients in the short term (9 trials; 1108 participants; SMD, 0.51; 95% CI, 0.20 to 0.82; I2 = 82%) and the medium term (5 trials; 771 participants; SMD, 0.29; 95% CI, 0.06 to 0.52; I2 = 57%). Conclusions and Relevance In this study, MBIs were associated with reductions in anxiety and depression up to 6 months postintervention in adults with cancer. Future trials should explore the long-term association of mindfulness with anxiety and depression in adults with cancer and determine its efficacy in more diverse cancer populations using active controls.
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- 2020
11. Psychological distress and experiences of Adolescents and Young Adults with cancer during the COVID‐19 pandemic: A cross‐sectional survey.
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Glidden, Camille, Howden, Kaitlyn, Romanescu, Razvan G., Hatala, Andrew, Scott, Ian, Deleemans, Julie M., Chalifour, Karine, Eaton, Geoff, Gupta, Abha A., Bolton, James M., Garland, Sheila N., Mahar, Alyson L., and Oberoi, Sapna
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PSYCHOLOGICAL distress ,YOUNG adults ,COVID-19 pandemic ,CANCER patients ,TEENAGERS - Abstract
Background: This study investigated prevalence of psychological distress, factors associated with distress, and experiences of Adolescents and Young Adults (AYAs) with cancer during the COVID‐19 pandemic. It also compared distress in this group to previously surveyed Canadian AYAs with cancer in 2018 by the Young Adults with Cancer in their Prime (YACPRIME) study. Methods: A cross‐sectional, online, self‐administered survey of AYAs diagnosed with cancer between 15 and 39 years of age was conducted. Psychological distress was measured by the Kessler Psychological Distress Scale (K10). Associations between variables and high psychological distress (K10 ≥ 25), and comparison of prevalence of psychological distress with the YACPRIME study were done using multivariable logistic regression. Summative qualitative content analysis analyzed participant experiences during this pandemic. Results: We included 805 participants. High psychological distress was present in over two‐thirds of the group (68.0%; 95% CI, 64.7%–71.2%). Employment impact during pandemic (AOR (adjusted odds ratio), 2.16; 95% CI, 1.41–3.31) and hematologic malignancy (AOR, 1.76; 95% CI 1.08–2.97) were associated with higher psychological distress, while older age [AOR, 0.95; 95% CI, 0.92–0.99] and personal income < $40,000 (AOR, 0.38; 95% CI, 0.24–0.58) were associated with lower distress. Adjusted odds of experiencing psychological distress among AYAs with cancer during pandemic compared to pre‐pandemic years was 1.85 (95% CI: 1.36–2.53). Overarching themes of pandemic experiences included: inferior quality of life, impairment of cancer care, COVID‐19 related concerns and extreme social isolation. Conclusion: AYAs diagnosed with cancer are experiencing high psychological distress during this pandemic. Distress screening and evidence‐based interventions to alleviate distress are essential. [ABSTRACT FROM AUTHOR]
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- 2022
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12. A Cross-Sectional Survey Exploring the Impact of the COVID-19 Pandemic on the Cancer Care of Adolescents and Young Adults.
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Howden, Kaitlyn, Glidden, Camille, Romanescu, Razvan G., Hatala, Andrew, Scott, Ian, Deleemans, Julie, Chalifour, Karine, Eaton, Geoff, Gupta, Abha A., Bolton, James M., Mahar, Alyson L., Garland, Sheila N., and Oberoi, Sapna
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COVID-19 pandemic ,YOUNG adults ,CANCER treatment ,TEENAGERS ,DIAGNOSIS - Abstract
We aimed to describe the negative and positive impacts of changes in cancer care delivery due to COVID-19 pandemic for adolescents and young adults (AYAs) in Canada, as well as the correlates of negative impact and their perspectives on optimization of cancer care. We conducted an online, self-administered survey of AYAs with cancer living in Canada between January and February 2021. Multiple logistic regression was used to identify factors associated with a negative impact on cancer care. Of the 805 participants, 173 (21.5%) experienced a negative impact on their cancer care including delays in diagnostic tests (11.9%), cancer treatment (11.4%), and appointments (11.1%). A prior diagnosis of mental or chronic physical health condition, an annual income of <20,000 CAD, ongoing cancer treatment, and province of residence were independently associated with a negative cancer care impact (p-value < 0.05). The majority (n = 767, 95.2%) stated a positive impact of the changes to cancer care delivery, including the implementation of virtual healthcare visits (n = 601, 74.6%). Pandemic-related changes in cancer care delivery have unfavorably and favorably influenced AYAs with cancer. Interventions to support AYAs who are more vulnerable to the adverse effects of the pandemic, and the thoughtful integration of virtual care into cancer care delivery models is essential. [ABSTRACT FROM AUTHOR]
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- 2021
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13. Relationship between tumor response at therapy completion and prognosis in patients with Group III rhabdomyosarcoma: A report from the Children's Oncology Group.
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Lautz, Timothy B., Chi, Yueh‐Yun, Tian, Jing, Gupta, Abha A., Wolden, Suzanne L., Routh, Jonathan C., Casey, Dana L., Dasgupta, Roshni, Hawkins, Douglas S., and Rodeberg, David A.
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RHABDOMYOSARCOMA ,JUVENILE diseases ,COMBINED modality therapy ,ONCOLOGY ,LOG-rank test - Abstract
A subset of patients with initially unresected (Clinical Group III) rhabdomyosarcoma achieve less than a complete response (CR) despite multimodal therapy. We assessed outcome based upon tumor response at the completion of all planned therapy. We studied 601 Clinical Group III participants who completed all protocol therapy without developing progressive disease on two Children's Oncology Group studies ARST0531 (n = 285) and D9803 (n = 316). Response was defined by imaging and categorized by response; complete resolution (CR), partial response (PR) or no response (NR). Failure‐free survival (FFS) and overall survival (OS) between response groups were compared using the log‐rank test. We found that radiographic response was CR in 393 (65.4%) and PR/NR in 208 (34.6%) patients. Achieving CR status was associated with study D9803, nonparameningeal (PM) primary sites, tumors ≤5 cm, noninvasive tumors and alveolar histology/FOXO fusion‐positive tumors. The overall 5‐year FFS was 75% for those achieving CR and 66.5% in those with PR/NR (adj. p = 0.094). Patients with PM primary site who achieved CR had significantly improved FFS (adj. p = 0.037) while those with non‐PM primary sites had similar outcomes (adj. p = 0.47). Radiographic response was not associated with OS (adj. p = 0.21). Resection of the end‐of‐therapy mass did not improve FFS (p = 0.12) or OS (p = 0.37). In conclusion, CR status at the end of protocol therapy in patients with PM Clinical Group III RMS was associated with improved FFS but not OS. Efforts to understand the biology and treatment response in patients with PM primary site are under investigation. What's new? Despite multi‐modal therapy, about a third of patients with rhabdomyosarcoma don't achieve a complete response to treatment. How does response affect survival? In this study, the authors found that, while a subset of patients had improved failure‐free survival (FFS), even those patients who achieved a complete radiographic response did not have improved overall survival (OS) compared to patients who achieved a partial or no response. In addition, resection of residual end‐of‐therapy masses was not associated with a survival benefit. Further research is needed to better understand the biology of these tumors and improve outcomes. [ABSTRACT FROM AUTHOR]
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- 2020
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14. High prevalence of persistent emotional distress in desmoid tumor.
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Ingley, Katrina M., Klein, Roberta, Theobalds, Nicole, Burtenshaw, Sally, Abdul Razak, Albiruni R., Chen, Bo, Xu, Wei, Gladdy, Rebecca, Li, Madeline, and Gupta, Abha A.
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DESMOID tumors ,ABDOMINAL wall ,REGRESSION analysis ,SARCOMA ,PSYCHOLOGICAL distress ,EMOTIONAL experience - Abstract
Objective: Clinical experience suggests a high prevalence of emotional distress in patients with desmoid tumor (DT). We examine longitudinal Distress Assessment and Response Tool (DART) scores to estimate prevalence and persistence of distress, and compare cross-sectional data between DT and malignant sarcoma cohorts, to identify predictors of distress.Methods: Patients with DT completed DART at: T1-diagnosis, T2-during, T3-<6 months, and T4-≥6 months, post-treatment. DART includes patient-reported outcome measures of physical symptoms (ESAS-r), depression (PHQ-9), anxiety (GAD-7), and social difficulties (SDI-21). Descriptive prevalence and persistence of anxiety, depression, and wellbeing are reported, and mixed model regression analyses determine predictors of distress.Results: Between 2012 and 2018, a total of 152 DART screens from 94 patients with DT were completed (T1: n = 44, T2: n = 31, T3: n = 22, T4: n = 55). Patients had a mean age 40 years, 78% were female and DT locations were abdominal wall (48%), extremity (30%), and mesentery (22%). Moderate to severe ESAS-r scores (≥4) persisted at T4 for anxiety (20%), depression (13%), and poor wellbeing (31%). Compared to 402 patients with malignant sarcoma, patients with abdominal wall sited DT reported severe PHQ-9 and GAD-7 scores twice as frequently. Abdominal wall location, female sex, history of mood problems, and psychosocial concerns were significant predictors of anxiety, depression, and poor wellbeing in DT.Conclusions: Adults with DT experience persistently high emotional distress compared to patients with malignant sarcoma. Women with abdominal wall DT, prior mood, and current psychosocial concerns need early attention within multidisciplinary treatment settings to reduce persistent distress. [ABSTRACT FROM AUTHOR]- Published
- 2020
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15. Increased local failure for patients with intermediate-risk rhabdomyosarcoma on ARST0531: A report from the Children's Oncology Group.
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Casey, Dana L., Chi, Yueh‐Yun, Donaldson, Sarah S., Hawkins, Douglas S., Tian, Jing, Arndt, Carola A., Rodeberg, David A., Routh, Jonathan C., Lautz, Timothy B., Gupta, Abha A., Yock, Torunn I., Wolden, Suzanne L., and Chi, Yueh-Yun
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RHABDOMYOSARCOMA ,ONCOLOGY ,CHILDREN ,RADIOTHERAPY ,OLDER patients - Abstract
Background: The objective of this study was to evaluate local control for patients with intermediate-risk rhabdomyosarcoma (RMS) treated on Children's Oncology Group (COG) protocol ARST0531.Methods: This study analyzed 424 patients with intermediate-risk RMS. Patients were randomized to chemotherapy with either vincristine, dactinomycin, and cyclophosphamide (VAC) or VAC alternating with vincristine and irinotecan. With the goal of improving local control, radiation therapy (RT) was delivered early at week 4 and was concurrent with irinotecan in the experimental arm. Individualized local control plans for children 24 months old or younger were allowed. Local failure on ARST0531 was compared with local failure on the preceding COG intermediate-risk study, D9803.Results: For patients with group I/II alveolar RMS (n = 55), the 5-year cumulative incidence of local failure was 13.4%; for group III alveolar RMS (n = 141), it was 20.2%; and for group III embryonal RMS (n = 228), it was 27.9% (P = .03). Among patients with group III disease, local failure did not differ by histology, site, nodal status, RT modality, or treatment arm. Local failure was worse for a tumor size >5 cm (32.3% vs 16.7%; P = .001). Among patients with group III embryonal RMS, local failure was higher on ARST0531 than D9803 (27.9% vs 19.4%; P = .03). After the exclusion of patients 24 months old or younger or patients who did not receive radiation, local failure remained significantly increased on ARST0531 (P = .02). After adjustments for clinical prognostic factors, event-free survival and overall survival were worse on ARST0531 (P = .004 and P = .05, respectively).Conclusions: Despite interventions designed to enhance local control, local control was inferior on ARST0531 in comparison with D9803. The reason for this is unclear, but it could be the reduced cyclophosphamide dose on ARST0531. [ABSTRACT FROM AUTHOR]- Published
- 2019
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16. A fertility needs assessment survey of male cancer patients.
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Perez, Samara, Lambert, Sylvie D., Lee, Virginia, Loiselle, Carmen G., Chan, Peter, Gupta, Abha, Lo, Kirk, Rosberger, Zeev, and Zelkowitz, Phyllis
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FERTILITY preservation ,PUBLIC health ,MEDICAL care ,MENTAL health of cancer patients ,PSYCHOLOGICAL well-being ,CANCER chemotherapy - Abstract
Objective: To describe fertility-related informational needs and practices, and to examine if demographic characteristics are related to these needs and practices.Methods: A needs assessment survey was conducted at three Canadian cancer centres.Results: 192 male cancer patients (Mage = 33.6) completed the survey. Most patients (70%) recalled having had a discussion with a health care provider regarding their fertility and 44% banked their sperm. Patients reported not getting all the information that they wanted, eg, the risk that a future child may have the same type of cancer (78%), and what was covered by insurance plans (71%). Barriers to sperm preservation were urgency to begin cancer treatment (49%), not planning to have a child in the future (47%) and worries that cancer could be passed on to future children (38%). Participants' age and being the parent of a child were significantly associated with having had a discussion about fertility. Participants' age, province, being the parent of a child and the desire for future children were significantly associated with fertility preservation.Conclusions: Discussions with health care providers were more frequent, and fertility preservation rates were higher than in past studies, but still not all patients' questions were answered. Misconceptions about passing on cancer to one's child, and that sperm preservation will delay treatment, should be dispelled. Health care providers can ask patients if they have any desire to have children in the future as a way to initiate a discussion of fertility preservation. Key information gaps and psychosocial resource needs are suggested to fully meet male cancer patients' fertility-related concerns. [ABSTRACT FROM AUTHOR]- Published
- 2018
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17. Anti-Müllerian Hormone in Female Adolescent Cancer Patients Before, During, and After Completion of Therapy: A Pilot Feasibility Study.
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Gupta, Abha A., Lee Chong, Amy, Deveault, Catherine, Traubici, Jeffrey, Maloney, Anne Marie, Knight, Samantha, Lorenzo, Armando, and Allen, Lisa
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ANTI-Mullerian hormone , *CANCER patients , *ONCOLOGY , *CYCLOPHOSPHAMIDE , *OVARIAN cancer - Abstract
Study Objective Alkylating agents are implicated in premature ovarian insufficiency. To optimize counseling regarding future ovarian function in survivors of adolescent cancer, we describe anti-Müllerian hormone (AMH) levels in female adolescents at diagnosis, during, and shortly after completion of chemotherapy. Design, Setting, Participants, Interventions, and Main Outcome Measures This was a prospective single-institution study. Participants were a mixed population of newly diagnosed postmenarchal female adolescents with malignancy. AMH was performed at diagnosis (T1), 6 months from diagnosis (T2), at end of therapy or 12 months [T3, whichever came first], 1 year after the end of therapy or 24 months from diagnosis [T4, whichever came first], and 18 months from the time of diagnosis (T5). All patients had baseline pelvic ultrasound examinations. Presence of menses and hot flashes were recorded at each time point. Results Sixteen participants with a median age at diagnosis of 14.3 years (range 12-17 years) were followed for 18.2 months (range, 14-24 months). Oncology diagnoses included leukemia, lymphoma, and sarcoma. Ten patients (62.5%) received alkylating agents with a median cumulative dose of 3041 mg/m 2 (range, 2639-6478 mg/m 2 ) of cyclophosphamide. Almost half (n = 7; 44%) experienced amenorrhea during treatment with resumption of menses in 6 of 7 patients (85%). Fifteen of 16 (94%) participants showed a decline in mean AMH levels by 6 months (T2) from diagnosis (15.8 IU/mL at T1 vs 6.5 IU/mL at T2; P = .003) and 12 of 15 (80%) showed at least some recovery of AMH (mean AMH at T4 = 13.2 IU/mL compared with 6.5 IU/mL at T2; P = .02). There was no difference in the mean decline nor recovery of AMH in those who did, vs did not receive cyclophosphamide. Conclusion To our knowledge, this is the largest series to date in adolescents showing that AMH is uniformly suppressed during cancer therapy and short-term recovery occurs in just more than half of the patients by 18-24 months. The contribution of short-term AMH measurements in predicting long-term ovarian function remains to be defined. Long-term follow-up with serial AMH levels is required to help predict those at risk for premature ovarian insufficiency. [ABSTRACT FROM AUTHOR]
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- 2016
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18. The Effect of Specialized Palliative Care on End-of-Life Care Intensity in AYAs with Cancer.
- Author
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Jewitt, Natalie, Rapoport, Adam, Gupta, Abha, Srikanthan, Amirrtha, Sutradhar, Rinku, Luo, Jin, Widger, Kimberley, Wolfe, Joanne, Earle, Craig C., Gupta, Sumit, and Kassam, Alisha
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PALLIATIVE treatment , *TERMINAL care , *YOUNG adults , *CANCER patient care , *HEMATOLOGIC malignancies , *CANCER treatment - Abstract
Context: Many adolescents and young adults (AYAs; 15-39 years) with cancer receive high intensity (HI) care at the end of life (EOL). Palliative care (PC) involvement in this population is associated with lower risk of HI-EOL care. Whether this association differs by specialized versus generalist PC (SPC, GPC) is unknown.Objectives: (1) To evaluate whether SPC had an impact on the intensity of EOL care received by AYAs with cancer; (2) to determine which subpopulations are at highest risk for reduced access to SPC.Methods: A decedent cohort of AYAs with cancer who died between 2000-2017 in Ontario, Canada was identified using registry and population-based data. The primary composite measure of HI-EOL care included any of: intravenous chemotherapy <14 days from death; more than one ED visit, more than one hospitalization or any ICU admission <30 days from death. Physician's billing codes were used to define SPC and GPC involvement.Results: Of 7,122 AYA decedents, 2,140 (30%) received SPC and 943 (13%) received GPC. AYAs who died in earlier years, those with hematologic malignancies, males and rural AYAs were least likely to receive SPC. No PC involvement was associated with higher odds of receiving HI-EOL care (odds ratio (OR) 1.5; p<0.0001). However, SPC was associated with the lowest risk of HI-EOL care (OR SPC versus GPC 0.8; p=0.007) and decreased odds of ICU admission (OR 0.7; p=0.006).Conclusion: SPC involvement was associated with the lowest risk of HI-EOL care in AYAs with cancer. However, access to SPC remains a challenge. [ABSTRACT FROM AUTHOR]- Published
- 2023
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19. Phase II study of oral ENMD-2076 administered to patients (pts) with advanced soft tissue sarcoma (STS)
- Author
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Herbert Loong, Blackstein, Martin E., Gupta, Abha A., Hogg, David, Culala, Lindsay, Nyquist-Schultz, Kjirsten, Baker, Stephanie, Wang, Lisa, and Razak, Albiruni R. A.
- Subjects
Cancer Research ,Oncology
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