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We also did not conduct performance characterisation studies and relied upon imaging and infusion protocols from a prior proof of concept study.12 The fluorophore dose and imaging time points were not individually optimised for each of the imaging platforms, but these techniques have demonstrated efficacy in NIR imaging of multiple malignancies.14-16 Finally, our study relies upon the primary surgeon's subjective impression of tumour NIR fluorescence and adequate tumour-margin delineation, rather than a standardised, quantifiable measure of fluorescence. Head and neck cancer, indocyanine green dye, intraoperative imaging, optical imaging, near-infrared imaging, precision surgery In this study, we compared the performance of a surgical robot-integrated NIR camera system to a dedicated NIR imaging platform for SWIG imaging during TORS for OPSCC. Keywords: head and neck cancer; indocyanine green dye; intraoperative imaging; near-infrared imaging; optical imaging; precision surgery EN head and neck cancer indocyanine green dye intraoperative imaging near-infrared imaging optical imaging precision surgery 589 593 5 08/05/22 20220901 NES 220901 Key Points Prior studies demonstrated a failure to identify and localise head and neck cancers via near-infrared (NIR) imaging of indocyanine green (ICG) with a robot-integrated platform. [Extracted from the article]

While optical imaging with near-infrared (NIR) fluorescent dye has been used in oncologic surgery, its use in the head and neck has not been established. We aimed to evaluate the feasibility of using NIR to visualize primary tumor and regional metastasis in head and neck malignancy. Patients undergoing resection of primary head and neck tumors were included in this pilot study. Each patient was injected with indocyanine green dye (ICG) the day prior to surgery. The VisionSense Iridium camera system was used to visualize the primary lesion, its margins, and neck dissection specimen intraoperatively. Fourteen patients were enrolled. Eighty-six percent of primary tumors showed fluorescence as compared with surrounding tissues. ICG positivity showed 100% sensitivity for pathologic nodes in 7 neck dissection specimens; however, for 3 patients, nonpathologic nodes also showed ICG positivity. NIR imaging with ICG dye can be considered for intraoperative imaging of head and neck lesions. [ABSTRACT FROM AUTHOR]