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Viral infections today remain one of the global problems. Despite the significant number of developed methods for the determination and study of viral particles, their practical use is difficult due to the complexity and a small number of existing measuring instruments. In addition, in a number of devices, there is a high proportion of manual operations that require highly qualified staff. Therefore, the problem of the development of new rapid methods for diagnosing viruses that allow getting accurate results in a short time in automatic mode is urgent. Instrumentation implementation of these methods should ensure high accuracy of measurements. One of the most sought-after areas is the development of fast and sensitive methods for determining viruses based on methods of electrophysical analysis. These methods can significantly reduce the analysis time and simplify the preparation of the investigated materials. The chapter provides a brief overview of modern biosensor methods for the virus’s detection.