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Porous materials are currently the basis of many optical sensors because of their ability to provide a higher interaction between the light and the analyte, directly within the optical structure. In this study, mesoporous TiO2 layers were fabricated using a bottom-up synthesis approach in order to develop optical sensing structures. In comparison with more typical top-down fabrication strategies where the bulk constitutive material is etched in order to obtain the required porous medium, the use of a bottom-up fabrication approach potentially allows increasing the interconnectivity of the pore network, hence improving the surface and depth homogeneity of the fabricated layer and reducing production costs by synthesizing the layers on a larger scale. The sensing performance of the fabricated mesoporous TiO2 layers was assessed by means of the measurement of several glucose dilutions in water, estimating a limit of detection even below 0.15 mg/mL (15 mg/dL). All of these advantages make this platform a very promising candidate for the development of low-cost and high-performance optical sensors. [ABSTRACT FROM AUTHOR]

Many optical sensors exploit the interesting properties of porous materials, as they ensure a stronger interaction between the light and the analyte directly within the optical structure. Most porous optical sensors are mainly based on porous silicon and anodized aluminum oxide, showing high sensitivities. However, the top-down strategies usually employed to produce those materials might offer a limited control over the properties of the porous layer, which could affect the homogeneity, reducing the sensor reproducibility. In this work, we present the bottom-up synthesis of mesoporous TiO2 Fabry-Pérot optical sensors displaying high sensitivity, high homogeneity, and low production cost, making this platform a very promising candidate for the development of high-performance optical sensors. [ABSTRACT FROM AUTHOR]