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This paper proposes a new method for multi-disciplinary optimisation of building spatial designs in the preliminary design stage. First it discusses two recently developed building spatial design optimisation methods, one using a super-structured approach and the other applying a superstructure free approach. Subsequently, a combination of the two methods into a new hybrid method is presented. A case study is demonstrated to compare the three methods based on their performance and the characteristics of their design evolution. First results show that the hybrid method could aid in the effective exploration of large design search spaces by selecting more confined design search spaces based on engineering knowledge.