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Your search keyword '"Amy C, Jackson"' showing total 3 results
Start Over Author "Amy C, Jackson" Topic organic chemistry
3 results on '"Amy C, Jackson"'

1. A Ring Expansion Approach To N-oxy-2,5-diketopiperazines

Author

Amy C. Jackson, James T. Olsen, Sasha Sundstrom, Kyle M. Lambert, and John L. Wood

Subjects
Organic Chemistry, Drug Discovery, Biochemistry, Article
Abstract

A ring expansion of tetramic acids (pyrrolidine-2,4-diones) to N-oxy-2,5-diketopiperazines (DKPs) is described. This method allows for the facile and late-stage construction of the hydroxamic acid moiety and can thereby serve as a general method for accessing N-oxy-2,5-DKP natural products.

Published
2022

2. Synthesis of Chiral Tetramic Acids: Preparation of (S)-5-Benzylpyrrolidine-2,4-dione from L-Phenylalanine Methyl Ester Hydrochloride

Author

Amy C. Jackson, Austin W Medley, Lauren E Markham, John L. Wood, and Kyle M. Lambert

Subjects
chemistry.chemical_compound, Chemistry, Hydrochloride, Organic Chemistry, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Organic chemistry, Physical and Theoretical Chemistry, ComputingMilieux_MISCELLANEOUS, Article, Phenylalanine methyl ester
Abstract

[Image: see text]

Published
2019
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3. Toward a Catalytic Atroposelective Synthesis of Diaryl Ethers Through C(sp2)–H Alkylation with Nitroalkanes

Author

Jeffrey L. Gustafson, Andrew N. Dinh, Sean T. Toenjes, Amy C. Jackson, Sean M. Maddox, Mirza A. Saputra, and Ryan R. Noorbehesht

Subjects
Steric effects, chemistry.chemical_classification, Atropisomer, 010405 organic chemistry, Chemistry, Organic Chemistry, Enantioselective synthesis, Alkylation, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, 0104 chemical sciences, Catalysis, chemistry.chemical_compound, Urea, Chirality (chemistry), Alkyl
Abstract

We report studies toward a small-molecule-catalytic approach to access atropisomeric diaryl ethers that proceeds through a C(sp2)–H alkylation using nitroalkanes as the alkyl source. A quaternary ammonium salt derived from quinine, containing a sterically hindered urea at the C-9 position, was found to effect atroposelective C(sp2)–H alkylation with moderate to good enantioselectivities across several naphthoquinone-containing diaryl ethers. Products could then be isolated in >95:5 er after one round of trituration. For several substrates that were evaluated, we obtained nitroethylated products in similar yields and selectivities.

Published
2018
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