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Your search keyword '"G Mahesh Kumar"' showing total 10 results
Start Over Author "G Mahesh Kumar" Topic organic chemistry
10 results on '"G Mahesh Kumar"'

1. Synthetic studies toward potent cytostatic macrolide bryostatin: an expedient synthesis of C1–C10 fragment

Author

J. S. Yadav, B. V. Subba Reddy, S. Aravind, and G. Mahesh Kumar

Subjects
chemistry.chemical_classification, Stereochemistry, Organic Chemistry, Regioselectivity, Tetrahydropyran, Biochemistry, Aldehyde, Kinetic resolution, chemistry.chemical_compound, Bryostatins, chemistry, Aldol reaction, Drug Discovery, Stereoselectivity, Bryostatin
Abstract

The stereoselective synthesis of C1–C10 fragment of cytostatic macrolide bryostatin is described. Two of the three chiral centers have been established via the Sharpless kinetic resolution of racemic allylic alcohol 15 followed by regioselective reduction of epoxy alcohol 8 with Red-Al. Diastereoselective Aldol reaction of an aldehyde 7 with methyl isobutyrate affords the corresponding β-hydroxyester 23 which is then transformed into tetrahydropyran ring system 3 via an intramolecular hemi-ketalization.

Published
2012

2. Lithium Perchlorate Catalyzed Reactions of Indoles: An Expeditious Synthesis of Bis(indolyl)methanes

Author

Ch. V. R. Murthy, Basi V. Subba Reddy, Ch. Madan, G. Mahesh Kumar, and Jhillu S. Yadav

Subjects
chemistry.chemical_compound, Electrophilic substitution, Chemistry, Organic Chemistry, Diethyl ether, Efficient catalyst, Medicinal chemistry, Catalysis, Lithium perchlorate
Abstract

Lithium perchlorate is found to catalyze efficiently the electrophilic substitution reactions of indoles with aldehydes and ketones in diethyl ether to afford the corresponding bis(indolyl)methanes in high yields. LiOTf is also found to be an efficient catalyst for the synthesis of these compounds.

Published
2001

3. Montmorillonite clay catalyzed in situ Prins-type cyclisation reaction

Author

B. V. Subba Reddy, G. Mahesh Kumar, Ch. V. R. Murthy, and Jhillu S. Yadav

Subjects
In situ, chemistry.chemical_compound, Montmorillonite, Chemistry, Organic Chemistry, Drug Discovery, Organic chemistry, complex mixtures, Biochemistry, Montmorillonite KSF, Catalysis
Abstract

Homoallylic alcohols smoothly undergo cross-coupling reactions with aldehydes on the surface of montmorillonite clay to generate 4-hydroxy-2,6-disubstituted tetrahydropyrans in high yields with high diastereoselectivity.

Published
2001

5. ChemInform Abstract: Lithium Perchlorate Catalyzed Reactions of Indoles: An Expeditious Synthesis of Bis(indolyl)methanes

Author

G. Mahesh Kumar, Ch. V. R. Murthy, Ch. Madan, Jhillu S. Yadav, and Basi V. Subba Reddy

Subjects
chemistry.chemical_compound, Electrophilic substitution, Chemistry, Organic chemistry, General Medicine, Diethyl ether, Efficient catalyst, Lithium perchlorate, Catalysis
Abstract

Lithium perchlorate is found to catalyze efficiently the electrophilic substitution reactions of indoles with aldehydes and ketones in diethyl ether to afford the corresponding bis(indolyl)methanes in high yields. LiOTf is also found to be an efficient catalyst for the synthesis of these compounds.

Published
2010

6. ChemInform Abstract: Indium Trihalide Mediated Regioselective Ring Opening of Aziridines: A Facile Synthesis of 2-Haloamines

Author

B. V. Subba Reddy, Jhillu S. Yadav, and G. Mahesh Kumar

Subjects
chemistry.chemical_compound, chemistry, Polymer chemistry, Trihalide, Organic chemistry, Halogenation, chemistry.chemical_element, Regioselectivity, General Medicine, Acetonitrile, Ring (chemistry), Indium
Abstract

A variety of N-tosyl aziridines undergo ring opening with indium trihalides in acetonitrile at ambient temperature to afford the corresponding haloamines in excellent yields with high regioselectivity.

Published
2010

8. ChemInform Abstract: Scandium Triflate Catalyzed Ferrier Rearrangement: An Efficient Synthesis of 2,3-Unsaturated Glycopyranosides

Author

Ch. V. R. Murthy, G. Mahesh Kumar, B. V. Subba Reddy, and Jhillu S. Yadav

Subjects
chemistry.chemical_classification, Ferrier rearrangement, Anomer, chemistry.chemical_element, Glycoside, General Medicine, Catalysis, chemistry.chemical_compound, chemistry, Organic chemistry, Phenols, Scandium, Selectivity, Trifluoromethanesulfonate
Abstract

Scandium(III) trifluoromethanesulfonate is found to catalyze efficiently the O-glycosidation of 3,4,6-tri-O-acetyl-d-glucal with various alcohols and phenols to afford the corresponding 2,3-unsaturated glycosides in excellent yields with good anomeric selectivity.

Published
2001

9. Indium Trihalide Mediated Regioselective Ring Opening of Aziridines: A Facile Synthesis of 2-Haloamines

Author

Jhillu S. Yadav, G. Mahesh Kumar, and B. V. Subba Reddy

Subjects
chemistry.chemical_compound, Indium halides, chemistry, Organic Chemistry, Polymer chemistry, Trihalide, chemistry.chemical_element, Regioselectivity, Ring (chemistry), Acetonitrile, Indium
Abstract

A variety of N-tosyl aziridines undergo ring opening with indium trihalides in acetonitrile at ambient temperature to afford the corresponding haloamines in excellent yields with high regioselectivity.

Published
2001

10. Scandium Triflate Catalyzed Ferrier Rearrangement: An Efficient Synthesis of 2,3-Unsaturated Glycopyranosides

Author

B. V. Subba Reddy, Ch. V. R. Murthy, G. Mahesh Kumar, and Jhillu S. Yadav

Subjects
chemistry.chemical_classification, Ferrier rearrangement, Anomer, Organic Chemistry, Glycoside, chemistry.chemical_element, Catalysis, chemistry.chemical_compound, chemistry, Organic chemistry, Scandium, Selectivity, Trifluoromethanesulfonate, Glucal
Abstract

Scandium(III) trifluoromethanesulfonate is found to catalyze efficiently the O-glycosidation of 3,4,6-tri-O-acetyl-d-glucal with various alcohols and phenols to afford the corresponding 2,3-unsaturated glycosides in excellent yields with good anomeric selectivity.

Published
2000

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