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Your search keyword '"Lee, Nicholas R."' showing total 2 results
Start Over Author "Lee, Nicholas R." Topic organic solvents
2 results on '"Lee, Nicholas R."'

1. Allylations of aryl/heteroaryl ketones: neat, clean, and sustainable. Applications to targets in the pharma- and nutraceutical industries.

Author

Li, Xiaohan, Wood, Alex B., Lee, Nicholas R., Gallou, Fabrice, and Lipshutz, Bruce H.

Subjects
KETONES, ORGANIC solvents, TECHNOLOGICAL innovations, UBIQUINONES
Abstract

Aromatic and heteroaromatic ketones bearing an α-methine proton can be deprotonated and mono-allylated in minutes in the complete absence of an organic solvent to arrive at the corresponding products in high isolated yields. Applications to synthetic targets including both MK-7 and MK-9, as well as coenzyme Q9 (CoQ9), utilizing this new technology are documented. [ABSTRACT FROM AUTHOR]

Published
2022
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2. Effects of Co-solvents on Reactions Run under Micellar Catalysis Conditions.

Author

Gabriel, Christopher M., Lee, Nicholas R., Bigorne, Florence, Klumphu, Piyatida, Parmentier, Michael, Gallou, Fabrice, and Lipshutz, Bruce H.

Subjects
*MICELLAR catalysis, *ORGANIC solvents, *MICELLES, *CHEMICAL reactions, *AQUEOUS solutions
Abstract

The impact of varying percentages of an organic solvent added to reactions run in aqueous nanomicelles as the reaction medium has been investigated. Issues such as rates of reaction, percent conversion, and yield, as well as various practical aspects (e.g., effect on stirring, etc.), are discussed, leading to an operationally simple method for the general improvement of potentially problematic systems across a broad range of reaction types, in particular for reactions run at scale. [ABSTRACT FROM AUTHOR]

Published
2017
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