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In this research a new derivatives of 3,3,5-trichloroisatins and 3,3-dichloroisatins were synthesized in good yields using catalyst-free one-pot reaction of isatins or N-alkylisatines, triphenylphosphine and carbon tetrachloride in acetonitrile at room temperature. Because of existing isatin core in synthesized compounds, the antioxidant activity was investigated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and power of compounds for reducing of ferric ion experiments and comparing the results with synthetic antioxidants (TBHQ and BHT). Easy, simple, fast and new procedure are the some advantages of this study. Heterocyclic system carrying indolin-2-one moiety has drawn tremendous interest of researchers in the area of synthetic organic and medicinal chemistry. During past decades, modifications mainly been made at the C-3 position of indolin-2-one and numerous compounds have been reported as drugs for treating various kinds of diseases. This easy separation of products with high yields and short time of reaction makes this protocol attractive and useful as an industrially viable. [ABSTRACT FROM AUTHOR]

The article describes ionic liquids [bmim][NO3] in the presence of 30% mol CuI as efficient media for the domino Knoevenagel–hetero–Diels–Alder reaction ofo-propargyloxy benzaldehydes as unactivated terminal alkynes with some active methylene compounds. Short reaction time, easy workup, good to excellent yields, and mild conditions are advantages of this new media. Supplemental materials are available for this article. Go to the publisher's online edition ofSynthetic Communications®to view the free supplemental file. [ABSTRACT FROM AUTHOR]

Urea polyfunctional derivatives were successfully synthesized via a one-pot, five-component nucleophilic addition/Ugi reaction sequence. Simplicity, solvent-free conditions, and good yields of products are advantages of this method. [ABSTRACT FROM PUBLISHER]

The multicomponent, one-pot reaction of dialkyl acetylenedicarboxylates with 2,3-dihydrophthalazine-1,4-dione in the presence of triphenyl phosphite or trialkyl phosphites leads to stable substituted phosphorylsuccinates in good yields. GRAPHICAL ABSTRACT [ABSTRACT FROM PUBLISHER]

5-(Alkylimino)-2-(diethoxyphosphoryl)-2,5-dihydrofuran-3,4-dicarboxylates are prepared via a one-pot, three-component reaction of α-ketophosphonates, isocyanides, and dialkyl acetylenedicarboxylates at room temperature and neutral conditions. The structures of the products were deduced from their 1H NMR, 13C NMR, and infrared spectra and mass spectrometry. [image omitted] [ABSTRACT FROM AUTHOR]

Dialkyl-2-(dialkoxyphosphonyl)-3-(1,6-dihydro-6-oxo-4-propylpyrimidin-2-ylthio) succinates and dialkyl-2-(dialkoxyphosphonyl)-3-(1,6-dihydro-6-oxopyrimidin-2-ylthio) succinates were synthesized in moderate to high yields using a novel, facile, and one-pot condensation of dialkyl acetylenedicarboxylates, trialkylphosphites, and thiouracil derivatives. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT [image omitted] [ABSTRACT FROM AUTHOR]

The Passerini reaction of α-ketophosphonates, isocyanides, and benzoic acid derivatives leads to 1-(N-alkylcarbamoyl)-1-(diethoxyphosphoryl)alkyl benzoates in one step at room temperature. The structures of products were assigned on the basis of their 1H NMR, 13C NMR, 31P NMR, and IR spectroscopic data. GRAPHICAL ABSTRACT[image omitted] [ABSTRACT FROM AUTHOR]

A versatile and highly efficient procedure has been introduced for preparation of spiro pyridodipyrimidines during the investigation of the reaction of 1,3-dimethyl-6- aminouracil with isatin derivatives, ninhydrin, and acenaphthoquinone under classical or microwave-assisted solvent-free conditions.Key words: isatin, ninhydrin, acenaphtoquinone, 1,3-dimethyl-6-aminouracil, solvent-free. Dans le cadre d’une étude de la réaction du 1,3-diméthyl-6-aminouracil avec des dérivés de l’isatine, la ninhydrine et l’acénaphtoquinone dans des conditions classiques ou des conditions sans solvant, assistées par des microondes, on a développé une méthode versatile et très efficace de préparation de spiropyridodipyrimidines.Mots-clés : isatine, ninhydrine, acénaphtoquinone, 1,3-diméthyl-6-amino-uracile, sans solvant.[Traduit par la Rédaction] [ABSTRACT FROM AUTHOR]

Isatin derivatives react with proline and N-Aryl Maleimides via decarboxylative azomethine ylide formation and subsequent 1,3-dipolar cycloaddition involving an exo-transition state to give new heterocyclic adducts in 71–94% yield. [ABSTRACT FROM AUTHOR]