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Your search keyword '"Maiti, Samarendra N."' showing total 3 results
Start Over Author "Maiti, Samarendra N." Topic organic synthesis
3 results on '"Maiti, Samarendra N."'

1. Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists

Author

Dounay, Amy B., Barta, Nancy S., Campbell, Brian M., Coleman, Corey, Collantes, Elizabeth M., Denny, Lynne, Dutta, Satavisha, Gray, David L., Hou, Dongfeng, Iyer, Rathna, Maiti, Samarendra N., Ortwine, Daniel F., Probert, Al, Stratman, Nancy C., Subedi, Rajendra, Whisman, Tammy, Xu, Wenjian, and Zoski, Kim

Subjects
*DRUG design, *ORGANIC synthesis, *PHARMACOLOGY, *PHENOXY groups, *ADRENERGIC uptake inhibitors, *CHEMICAL agonists, *DOPAMINE, *NORADRENALINE, *THERAPEUTICS
Abstract

Abstract: Preclinical studies suggest that compounds with dual norepinephrine reuptake inhibitor (NRI) and 5-HT1A partial agonist properties may provide an important new therapeutic approach to ADHD, depression, and anxiety. Reported herein is the discovery of a novel chemical series with a favorable NRI and 5-HT1A partial agonist pharmacological profile as well as excellent selectivity for the norepinephrine transporter over the dopamine transporter. [Copyright &y& Elsevier]

Published
2010
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2. A versatile copper-catalyzed coupling reaction of pyridin-2(1H)-ones with aryl halides

Author

Filipski, Kevin J., Kohrt, Jeffrey T., Casimiro-Garcia, Agustin, Van Huis, Chad A., Dudley, Danette A., Cody, Wayne L., Bigge, Christopher F., Desiraju, Shrilakshmi, Sun, Shaoyi, Maiti, Samarendra N., Jaber, Mohamad R., and Edmunds, Jeremy J.

Subjects
*QUINOLINE, *ORGANIC synthesis, *CATALYSIS, *PYRIDINE
Abstract

Abstract: A robust method has been developed to couple a wide variety of pyridin-2-ones and aryl halides. This C–N bond forming reaction makes use of catalytic copper(I) iodide and the ligand 8-hydroxyquinoline. These conditions tolerate a wide degree of functionality on both the aryl halide and pyridin-2-one reactants and have resulted in numerous examples being synthesized. [Copyright &y& Elsevier]

Published
2006
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3. Synthesis of methyl-, fluoro-, and chloro-substituted 6-hydroxyisoindolin-1-ones

Author

Powers, James J., Favor, David A., Rankin, Trent, Sharma, Rashmi, Pandit, Chetan, Jeganathan, Azhwarsamy, and Maiti, Samarendra N.

Subjects
*ORGANIC synthesis, *SUBSTITUTION reactions, *ORGANOHALOGEN compounds, *KETONES, *REACTION mechanisms (Chemistry)
Abstract

Abstract: The synthesis of a series of methyl-, fluoro-, and chloro-substituted 6-hydroxyisoindolin-1-ones is described. [Copyright &y& Elsevier]

Published
2009
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