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The development of palladium-catalyzed α-arylation of carbonyl compounds has emerged as a new avenue in the design of new routes for the synthesis of natural products and active pharmaceutical ingredients (APIs). In many cases, syntheses based on α-arylation strategies provide elegant routes in terms of increasing the overall yields, improving the synthesis scope, and decreasing the number of steps. This microreview aims to highlight the importance of palladium-catalyzed α-arylation methodologies, covering a range of notable reported examples of the total syntheses of structurally important compounds, thereby highlighting the importance of this powerful methodology for key steps in organic synthesis. [ABSTRACT FROM AUTHOR]

Cover Feature: Synthesis of Pyrrolo[2,1-a]isoquinoline Class of Natural Product Crispine A (Eur. J. Org. Keywords: Alkaloids; Crispine A; Natural product; Pyrrolo[2,1-a]isoquinoline; Synthetic Methods; Total synthesis EN Alkaloids Crispine A Natural product Pyrrolo[2,1-a]isoquinoline Synthetic Methods Total synthesis 4896 4896 1 09/29/21 20210921 NES 210921 B The Cover Feature b shows naturally occurring (2 I S i ,3 I S i )- and (2 I S i ,3 I R i )-tetrahydro-3-hydroxy-5-oxo-2,3-furan dicarboxylic acid bearing, chemically amenable functional groups that are an ideal choice for the enantiopure synthesis of the (-)- and (+)-Crispine A, respectively. Alkaloids, Crispine A, Natural product, Pyrrolo[2,1-a]isoquinoline, Synthetic Methods, Total synthesis. [Extracted from the article]

Review: [recent applications of α-arylation in total syntheses both of natural products and of active pharmaceutical ingredients; 80 refs. [ABSTRACT FROM AUTHOR]