1. Environmental Factors Can Influence Mitochondrial Inheritance in the Saccharomyces Yeast Hybrids
- Author
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Yu-Yi Hsu and Jui Yu Chou
- Subjects
0301 basic medicine ,Glycerol ,Mating type ,Inheritance Patterns ,lcsh:Medicine ,Yeast and Fungal Models ,Saccharomyces ,Paradoxus ,Biochemistry ,Zygotes ,Animal Cells ,lcsh:Science ,DNA, Fungal ,Energy-Producing Organelles ,Genetics ,Multidisciplinary ,biology ,Organic Compounds ,Monosaccharides ,Inheritance (genetic algorithm) ,Mitochondrial DNA ,Nuclear DNA ,Mitochondria ,Nucleic acids ,Chemistry ,Experimental Organism Systems ,OVA ,Physical Sciences ,Saccharomyces Cerevisiae ,Cellular Structures and Organelles ,Cellular Types ,Research Article ,Genotype ,Forms of DNA ,030106 microbiology ,Saccharomyces cerevisiae ,Carbohydrates ,Monomers (Chemistry) ,Environment ,Bioenergetics ,Research and Analysis Methods ,DNA, Mitochondrial ,Ammonium Chloride ,03 medical and health sciences ,Model Organisms ,Osmotic Pressure ,Stress, Physiological ,Polymer chemistry ,Biology and life sciences ,lcsh:R ,Organic Chemistry ,Ubiquitination ,Organisms ,Fungi ,Chemical Compounds ,DNA ,Cell Biology ,biology.organism_classification ,Genes, Mating Type, Fungal ,Yeast ,030104 developmental biology ,Glucose ,Germ Cells ,Hybridization, Genetic ,lcsh:Q ,Mitochondrial Genetics - Abstract
Mitochondria play a critical role in the generation of metabolic energy and are crucial for eukaryotic cell survival and proliferation. In most sexual eukaryotes, mitochondrial DNA (mtDNA) is inherited from only one parent in non-Mendelian inheritance in contrast to the inheritance of nuclear DNA. The model organism Saccharomyces cerevisiae is commonly used to study mitochondrial biology. It has two mating types: MATa and MATα. Previous studies have suggested that the mtDNA inheritance patterns in hybrid diploid cells depend on the genetic background of parental strains. However, the underlying mechanisms remain unclear. To elucidate the mechanisms, we examined the effects of environmental factors on the mtDNA inheritance patterns in hybrids obtained by crossing S. cerevisiae with its close relative S. paradoxus. The results demonstrated that environmental factors can influence mtDNA transmission in hybrid diploids, and that the inheritance patterns are strain dependent. The fitness competition assay results showed that the fitness differences can explain the mtDNA inheritance patterns under specific conditions. However, in this study, we found that fitness differences cannot fully be explained by mitochondrial activity in hybrids under stress conditions.
- Published
- 2016