7 results on '"Yang Weili"'
Search Results
2. Associations of gestational exposure to organophosphate esters with gestational age and neonatal anthropometric measures: The HOME study.
- Author
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Yang, Weili, Braun, Joseph M., Vuong, Ann M., Percy, Zana, Xu, Yingying, Xie, Changchun, Deka, Ranjan, Calafat, Antonia M., Ospina, Maria, Burris, Heather H., Yolton, Kimberly, Cecil, Kim M., Lanphear, Bruce P., and Chen, Aimin
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GESTATIONAL age ,PREMATURE labor ,PREGNANCY outcomes ,BIRTH weight ,ESTERS ,HYPERTENSION - Abstract
Organophosphate esters (OPEs) are developmental toxicants in experimental studies of animals, but limited evidence is available in humans. We included 340 mother-infant pairs in the Health Outcomes and Measures of the Environment (HOME) Study (Cincinnati, Ohio, USA) for the analysis. We evaluated gestational exposure to OPEs with gestation age at birth and newborn anthropometric measures. We quantified four OPE urinary metabolites at 16 weeks and 26 weeks of gestation. We extracted gestational age at birth, newborn weight, length, and head circumference from the chart review. We calculated z-scores for these anthropometric measures and the ponderal index. We used multiple informant models to examine the associations between repeated OPE measurements and the outcomes. We used modified Poisson regression to estimate the association of gestational exposure to OPEs with preterm birth. We also explored effect modification by infant sex and the potential mediation effect by the highest maternal blood pressure and glucose levels. We found that bis(2-chloroethyl) phosphate (BCEP) at 16 weeks and diphenyl phosphate at 26 weeks of pregnancy were positively associated with gestational age and inversely associated with preterm birth. In female newborns, BCEP at 16 weeks was inversely related to birth weight and length z-scores. In male newborns, we observed negative associations of 26-week di-n-butyl phosphate with the ponderal index at birth. No mediation by the highest maternal blood pressure or glucose levels during pregnancy was identified. In this cohort, gestational exposure to some OPEs was associated with gestational age, preterm birth, and neonatal anthropometric measures. Certain associations tended to be window- and infant sex-specific. [Display omitted] • BCEP was positively associated with gestation age and inversely with preterm birth. • DPHP was positively associated with gestation age and inversely with preterm birth. • BCEP was inversely associated with birth weight and length z-scores in females. • DNBP was inversely associated with the ponderal index at birth in males. • Associations of OPEs and pregnancy outcomes might be window- and infant sex-specific. [ABSTRACT FROM AUTHOR]
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- 2023
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3. Gestational Exposure to Organophosphate Esters (OPEs) in Relation to Maternal Health and Pregnancy Outcomes in the HOME Study
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Yang, Weili
- Subjects
- Environmental Health, Organophosphate esters, Replacement flame retardants, Hypertensive disorders of pregnancy, Gestational diabetes mellitus, Preterm birth, Infant anthropometry
- Abstract
Background: Organophosphate esters (OPEs) are widely used in consumer products. Their urinary metabolites, as biomarkers of exposure, are detected in the general population including pregnant women and children. Evidence supports that OPEs cause endocrine disruption, cross the placenta, and induce developmental toxicities, raising concerns about the impact of exposure during sensitive periods (such as pregnancy and fetal stage) on maternal health and infant outcomes.Methods: Using data from the Health Outcomes and Measures of the Environment (HOME) Study, we quantified four OPE metabolites in maternal spot urine samples collected at 16 week- and 26 week-pregnancy, and birth, including bis(2-chloroethyl) phosphate (BCEP), bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), di-n-butyl phosphate (DNBP), and diphenyl phosphate (DPHP). We extracted maternal health parameters (blood pressure [BP], glucose tolerance, diagnoses of hypertensive disorders of pregnancy [HDP], and gestational diabetes mellitus [GDM]) and pregnancy outcomes (gestational age, birth weight, length, head circumference, and preterm birth [PTB]) via chart review. At the 4-week postpartum visit, we measured the same anthropometric parameters in infants. We calculated sex and gestational age standardized z-scores for infant anthropometric parameters, weekly growth rates, and the ponderal index. We used general linear models, linear mixed models, and multiple informant models to examine the associations of OPE exposure with 1) repeated measurements of BP and the highest BP = 20 weeks, 2) plasma glucose levels from the glucose challenge test, 3) gestational age, z-scores of infant size, the ponderal index, and weekly growth rates. We used modified Poisson regression to estimate risk ratios (RRs) of OPEs with HDP, elevated glucose levels, and PTB. We tested effect modification by maternal characteristics for glucose levels and by infant sex for pregnancy outcomes. We applied a Bayesian kernel machine regression (BKMR) framework to examine the associations of OPE mixtures with glucose levels and infant size at 4 weeks. Finally, we explored if the associations between OPE and pregnancy outcomes were mediated via maternal blood pressure or glucose.Results: For each unit of log10 increase, average BCEP was associated with an increase of 1.62 mmHg (95% CI: 0.004, 3.24) of the two highest diastolic BP= 20 weeks. DNBP at 16 weeks was marginally associated with HDP (RR: 2.98, 95% CI: 0.97, 9.15). Increasing trends of diastolic BP were observed across DPHP tertiles. BCEP at 26 weeks were positively associated with gestational age (ß=0.33 week, 95% CI: 0.06, 0.61) and BCEP or DPHP at 26 weeks were inversely associated with PTB (for BCEP, RR=0.48, 95% CI: 0.27, 0.83; for DPHP, RR=0.34, 95% CI: 0.12, 0.97). Higher DPHP at 16 weeks and BCEP at delivery were associated with increased z-scores at 4 weeks in all infants and males. BDCIPP at delivery was positively associated with z-scores in all infants and females. We did not find associations of OPE with maternal glucose tolerance or weekly growth rates, or mediation effects of maternal blood pressure and glucose on pregnancy outcomes.Conclusion: Gestational OPE exposure was associated with altered maternal blood pressure. Associations of OPEs with pregnancy outcomes tended to be window- and infant sex-specific.
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- 2022
4. Maternal urinary organophosphate ester metabolite concentrations and glucose tolerance during pregnancy: The HOME Study.
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Yang, Weili, Braun, Joseph M., Vuong, Ann M., Percy, Zana, Xu, Yingying, Xie, Changchun, Deka, Ranjan, Calafat, Antonia M., Ospina, Maria, Yolton, Kimberly, Cecil, Kim M., Lanphear, Bruce P., and Chen, Aimin
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ORGANOPHOSPHORUS compounds , *BLOOD sugar , *CARBOXYLIC acids , *QUESTIONNAIRES , *LONGITUDINAL method , *PROBABILITY theory - Abstract
Background: Endocrine-disrupting chemicals may alter glucose homeostasis, especially during pregnancy. Biomonitoring studies suggest ubiquitous human exposure to organophosphate esters (OPEs), chemicals with endocrine-disrupting capabilities. Few studies have examined the association between maternal exposure to OPEs and blood glucose during pregnancy.Methods: With data from 301 pregnant women in the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort in Cincinnati, Ohio, USA, we examined whether OPE concentrations were associated with changes in blood glucose. We quantified four OPE metabolites in maternal spot urine samples collected at 16- and 26-weeks pregnancy. We extracted results from the glucose challenge test (GCT) and oral glucose tolerance test (OGTT) via medical chart review. Women with GCT ≥ 140 mg/dL or any abnormal values in OGTT (≥ 95 mg/dL fasting glucose, ≥ 180 mg/dL 1-h glucose, ≥ 155 mg/dL 2-h glucose, ≥ 140 mg/dL 3-h glucose) were defined as having elevated glucose levels. We used linear regression and Bayesian Kernel Machine Regression (BKMR) to estimate the associations of individual OPE metabolites and OPE mixtures with blood glucose levels during pregnancy. We used modified Poisson regression to estimate the associations of OPE metabolite concentrations with elevated glucose levels. We further examined effect measure modification by maternal characteristics (age, pre-pregnancy body mass index [BMI], and race/ethnicity).Results: Diphenyl phosphate (DPHP) had the highest geometric mean concentration of the urinary OPE metabolites (1.83 μg/L at 16 weeks, 1.24 μg/L at 26 weeks). Thirty women (10.0%) had elevated glucose levels. Individual OPE metabolites or their mixtures were not significantly associated with continuous GCT results. We did not observe effect measure modification by maternal age, pre-pregnancy BMI categories, or race/ethnicity. Compared with women in the 1st tertile of average DPHP of 16- and 26 weeks of pregnancy, women in the 3rd tertile tended to have a reduced risk of elevated glucose levels (RR = 0.41, 95% CI = 0.16-1.06, p for trend = 0.06).Conclusion: In this cohort, maternal urinary OPE metabolite concentrations were weakly associated with blood glucose levels during pregnancy. [ABSTRACT FROM AUTHOR]- Published
- 2022
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5. Maternal urinary OPE metabolite concentrations and blood pressure during pregnancy: The HOME study.
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Yang, Weili, Braun, Joseph M., Vuong, Ann M., Percy, Zana, Xu, Yingying, Xie, Changchun, Deka, Ranjan, Calafat, Antonia M., Ospina, Maria, Werner, Erika, Yolton, Kimberly, Cecil, Kim M., Lanphear, Bruce P., and Chen, Aimin
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SYSTOLIC blood pressure , *BLOOD pressure , *DIASTOLIC blood pressure , *PREGNANCY , *INTRACLASS correlation , *SPECIFIC gravity - Abstract
Few studies have examined the association between maternal exposure to organophosphate esters (OPEs) and systolic/diastolic blood pressure (SBP/DBP) during pregnancy. We analyzed data from 346 women with a singleton live birth in the HOME Study, a prospective birth cohort in Cincinnati, Ohio, USA. We quantified four OPE metabolites in maternal spot urine samples collected at 16 and 26 weeks pregnancy, standardized by specific gravity. We calculated intraclass correlation coefficients (ICCs). We extracted the first two recorded BP measurements (<20 weeks), the two highest recorded BP measurements (≥20 weeks), and diagnoses of hypertensive disorders of pregnancy (HDP) via chart review. Women with two BP measurements ≥140/90 mmHg or HDP noted in the chart at ≥20 weeks pregnancy were defined as HDP cases. We used linear mixed models and modified Poisson regression with covariate adjustment to estimate associations between OPE concentrations as continuous variables or in tertiles with maternal BP and HDP. ICCs of OPEs were 0.17–0.45. Diphenyl phosphate (DPHP) had the highest geometric mean concentration among OPE metabolites. Increasing the average bis(2-chloroethyl) phosphate (BCEP) concentrations were positively associated with two highest recorded DBP ≥20 weeks pregnancy. Compared with women in the 1st DPHP tertile, women in the 3rd tertile at 16 weeks pregnancy had 1.72 mmHg (95% CI: -0.01, 3.46) higher DBP <20 weeks pregnancy, and women in the 3rd tertile of the average DPHP concentrations had 2.25 mmHg (95% CI: 0.25, 4.25) higher DBP ≥20 weeks pregnancy. 33 women (9.5%) were identified with HDP. Di-n-butyl phosphate (DNBP) concentrations at 16 weeks were positively associated with HDP, with borderline significance (RR = 2.98, 95% CI 0.97–9.15). Other OPE metabolites were not significantly associated with HDP. Maternal urinary BCEP and DPHP concentrations were associated with increased BP during pregnancy. Maternal urinary DNBP concentrations were associated with HDP, with borderline significance. [ABSTRACT FROM AUTHOR]
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- 2022
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6. Childhood urinary organophosphate esters and cognitive abilities in a longitudinal cohort study.
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Percy, Zana, Chen, Aimin, Yang, Weili, Braun, Joseph M., Lanphear, Bruce, Ospina, Maria, Calafat, Antonia M., Xie, Changchung, Cecil, Kim M., Vuong, Ann M., Xu, Yingying, and Yolton, Kimberly
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COGNITIVE ability , *COHORT analysis , *LONGITUDINAL method , *POOR children , *FIREPROOFING agents - Abstract
The use of organophosphate esters (OPEs) as flame retardants, which has increased over the past two decades, raises concerns that OPEs may be harmful to humans, especially children. Animal studies and some human studies have reported that OPEs may adversely impact brain development, but few human studies evaluated OPE exposure during early childhood and neurodevelopmental outcomes. We aimed to fill this knowledge gap with the present study on urinary OPE metabolite concentrations at ages 1–5 years and cognitive abilities at 8 years. We used data of 223 children from the Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort in Cincinnati, Ohio. The point estimates for bis-2-chloroethyl-phosphate (BCEP) and bis(1,3-dichloro-2-propyl)-phosphate (BDCIPP) in association with IQ tended to be small and positive, while the point estimates for diphenyl-phosphate (DPHP) were small and negative, with 95% CIs including the null. However, we did find that socioeconomic status (SES) variables modified associations between OPEs and child IQ, with adverse OPE-IQ associations being stronger in socioeconomically disadvantaged children than in others. We identified an additional 1- to 2-point decrease in Full Scale IQ for every log-unit increase in BDCIPP, BCEP, and DPHP among those with lower maternal education, non-white race, lower income, or living in more deprived neighborhoods. We observed similar results for the Perceptual Reasoning, Verbal Comprehension, and Working Memory Index Scores. We suspect that there is residual confounding related to socioeconomic disadvantage, which was not captured with the available SES variables typically used in epidemiologic studies. • This cohort study examines OPEs at ages 1–5 years and cognition at age 8 years. • In child urine, BCEP was detected at 90–95%, BDCIPP at 99%, and DPHP at 99–100%. • Point estimates for OPEs and cognition were small, and 95% CIs included the null. • SES variables modified associations; disadvantaged children have worse outcomes. [ABSTRACT FROM AUTHOR]
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- 2022
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7. Early-life exposure to a mixture of organophosphate esters and child behavior.
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Percy, Zana, Chen, Aimin, Sucharew, Heidi, Yang, Weili, Vuong, Ann M., Braun, Joseph M., Lanphear, Bruce, Ospina, Maria, Calafat, Antonia M., Cecil, Kim M., Xu, Yingying, and Yolton, Kimberly
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CHILD behavior , *BEHAVIORAL assessment of children , *STRUCTURAL equation modeling , *LATENT variables , *TEENAGE pregnancy , *FIREPROOFING agents , *PARENT-infant relationships - Abstract
Organophosphate esters (OPEs), widely used as flame retardants and plasticizers for commercial and residential purposes, are suspected of being neurotoxic. We aimed to assess exposure to an OPE mixture in early life and its relationship to parent-reported child behavior. We measured urinary concentrations of three OPE metabolites, bis-2-chloroethyl phosphate (BCEP), bis(1,3-dichloro-2-propyl) phosphate (BDCIPP), and diphenyl phosphate (DPHP), at pregnancy (16 and 26 weeks of gestation and delivery) and postnatal time points (ages 1, 2, 3, and 5 years) in the Health Outcomes and Measures of the Environment Study, a longitudinal pregnancy and birth cohort in Cincinnati, Ohio, USA (enrolled 2003–2006, n = 219). We used latent variable analysis in structural equations models and quantile g-computation to investigate associations of a mixture of the three OPE metabolites with parent-reported child behaviors at 3 and 8 years, measured using the Behavioral Assessment System for Children, Second Edition. Higher log-transformed urinary OPE latent variable values at 16 weeks were associated with fewer externalizing problem behaviors (ß = −5.74; 95% CI = −11.24, −0.24) and fewer overall behavioral problems at age 3 years (ß = −5.26; 95% CI = −10.33, −0.19), whereas having higher OPEs at delivery was associated with poorer overall behavioral problems at age 3 years (ß = 2.87; 95% CI = 0.13, 5.61). OPE latent variable values at 16 weeks, 26 weeks, and delivery were not associated with child behavior at 8 years. However, higher OPE latent variable values at 3 years were associated with fewer externalizing behaviors at 8 years (ß = −2.62; 95% CI = −5.13, −0.12). The quantile g-computation estimates had directions largely consistent with the latent variable analysis results. Pregnancy and postnatal urinary OPE metabolite mixtures were associated with child internalizing, externalizing, and overall negative behaviors at 3 and 8 years, but we did not identify a consistent pattern in terms of the direction of the effects or a particularly sensitive time point. • We studied pregnancy and postnatal OPEs and child behavior in a longitudinal cohort. • We used latent variable analysis and quantile g-computation to assess OPE mixtures. • Pregnancy OPEs were associated with child behavior at 3 years. • The direction of associations and vulnerable time points were inconsistent. [ABSTRACT FROM AUTHOR]
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- 2023
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