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Your search keyword '"Shi Mengfan"' showing total 3 results
Start Over Author "Shi Mengfan" Topic orobanchaceae
3 results on '"Shi Mengfan"'

1. Protective effect of total phenylethanoid glycosides from Monochasma savatieri Franch on myocardial ischemia injury.

Author

Shi M, He W, Liu Y, Li X, Yang S, and Xu Q

Subjects
Animals, Cardiotonic Agents isolation & purification, Cardiotonic Agents pharmacology, Cell Survival drug effects, Glycosides isolation & purification, Glycosides pharmacology, Heart drug effects, Heart physiopathology, Humans, Hydrogen Peroxide, Isoproterenol, Myocardial Ischemia chemically induced, Myocardial Ischemia pathology, Myocardial Ischemia physiopathology, Myocardium pathology, Myocytes, Cardiac drug effects, Phenols isolation & purification, Phenols pharmacology, Plant Extracts chemistry, Plant Extracts pharmacology, Rats, Rats, Sprague-Dawley, Cardiotonic Agents therapeutic use, Glycosides therapeutic use, Myocardial Ischemia drug therapy, Orobanchaceae chemistry, Phenols therapeutic use, Phytotherapy, Plant Extracts therapeutic use
Abstract

The present study was designed to investigate the cardioprotective effect of total phenylethanoid glycosides from Monochasma savatieri Franch (TPG). The data showed that there were mainly four phenylethanoid glycosides isolated and identified from TPG. TPG significantly increased cells viability and inhibited morphological changes on H9c2 cardiomyocytes induced by H2O2 or Na2S2O4. In addition, TPG significantly decreased T-wave elevation and histopathological changes of heart tissues in myocardial infracted rats induced by isoproterenol. It also significantly reduced the infarct size induced by ligating the coronary artery in rats, increased the activities of antioxidative enzymes superoxide dismutase (SOD), the content of glutathione (GSH), and decreased the leakage of lactic dehydrogenase (LDH), the activities of creatine kinase (CK) and the content of maleic dialdehyde (MDA). In conclusion, these results suggested that TPG from Monochasma savatieri Franch might be developed as new natural medicine or food additives with effects of prevention of coronary artery disease due to its significant antioxidant activity., (Copyright © 2013 Elsevier GmbH. All rights reserved.)

Published
2013
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2. Antimicrobial, anti-inflammatory activities and toxicology of phenylethanoid glycosides from Monochasma savatieri Franch. ex Maxim

Author

Shilin Yang, Xiaoran Li, Ying-ying Zhu, Shi Mengfan, Shu Pan, Qiongming Xu, He Wenjun, Yanli Liu, and Li Mo

Subjects
medicine.drug_class, Anti-Inflammatory Agents, Microbial Sensitivity Tests, Pharmacology, medicine.disease_cause, Anti-inflammatory, Rats, Sprague-Dawley, chemistry.chemical_compound, Mice, Orobanchaceae, In vivo, Sepsis, Drug Discovery, Streptococcus pneumoniae, medicine, Animals, Edema, Pseudomonas Infections, Glycosides, Medicine, Chinese Traditional, Lung, Mice, Inbred ICR, Granuloma, Bacteria, Chemistry, Pseudomonas aeruginosa, Phenylethanoid, Pneumonia, Staphylococcal Infections, Antimicrobial, Anti-Bacterial Agents, Rats, Staphylococcus aureus, Antibacterial activity, Phytotherapy
Abstract

Ethnopharmacological relevance Monochasma savatieri Franch. ex Maxim is used for treating many diseases in Traditional Chinese Medicine. Aim of the study The present study was designed to evaluate antibacterial, anti-inflammatory activities and toxicity of the total phenylethanoid glycosides from Monochasma savatieri Franch. ex Maxim (TPG). Materials and methods The antibacterial activity of TPG was checked by MIC and MBC in vitro; survival of mice with Pseudomonas aeruginosa or Staphylococcus aureus infection-induced sepsis was investigated to evaluate antibacterial activity of TPG in vivo. Additionally, antibacterial activities of TPG were also investigated in a Pseudomonas aeruginosa infection-induced pneumonia in the mice model. Cotton pellet induced granuloma and xylene induced ear swelling in mice models were used to quantify the anti-inflammatory activity. Results TPG showed a significant possess bacteriostatic properties against five bacteria strains at a concentration between 0.0625 and 16 mg/ml. Moreover, TPG has bactericidal activity against Pseudomonas aeruginosa , Streptococcus pneumoniae or Escherichia coli . TPG (60, 120, and 180 mg/kg) prolonged survival rate of mice with Pseudomonas aeruginosa or Staphylococcus aureus infection-induced sepsis. In addition, TPG (180 mg/kg) could reduce the bacterial colony-forming units in lung tissue. Furthermore, TPG (60–180 mg/kg) had significantly reduced xylene-induced ear edema and granulomat formation induced by cotton pellet at a dose-dependent manner. In addition, administration of TPG (1.5 g/kg) for 15 days did not result in toxicities in liver, kidney, spleen and thymus tissue in rats. Conclusion These results indicated that TPG might be useful for the development of a novel treatment for respiratory infections or pneumonia caused by Pseudomonas aeruginosa or Staphylococcus aureus .

Published
2013

3. Phenylethanoid Glycosides from Monochasma savatieri and Their Anticomplement Activity through the Classical Pathway

Author

Shi Mengfan, Yanli Liu, Shilin Yang, Min Li, and Qiongming Xu

Subjects
Erythrocytes, Scrophulariaceae, Stereochemistry, Pharmaceutical Science, Monochasma savatieri, Analytical Chemistry, chemistry.chemical_compound, Classical complement pathway, Orobanchaceae, Drug Discovery, Animals, Complement Pathway, Classical, Glycosides, chemistry.chemical_classification, Pharmacology, Complement Inactivator Proteins, Sheep, biology, Molecular Structure, Organic Chemistry, Glycoside, Phenylethanoid, biology.organism_classification, chemistry, Complementary and alternative medicine, Molecular Medicine, Rabbits, Drugs, Chinese Herbal
Abstract

Five new phenylethanoid glycosides, savasides A–E (1–5), along with 6 known ones were isolated from the whole plant of Monochasma savatieri Franch. The structures of 1–5 were elucidated on the basis of spectroscopic data analysis. Moreover, all isolated compounds were evaluated for anticomplement activity through the classical pathway.

Published
2013
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