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Simple Summary: This systematic review and meta-analysis examines the impact of cancer and its treatment on orthodontic treatment success. Existing studies show significant gaps in understanding the relationship between anti-cancer medications and orthodontic care, necessitating further research. The review selected five studies with varying methodologies, finding a strong association between radiotherapy, antineoplastic drugs, and reduced success in orthodontic treatment. The results indicate that while orthodontic treatments can be effective for children undergoing chemotherapy, their effectiveness may diminish in older populations. The review underscores the importance of considering cancer therapies in orthodontic planning to optimize results and minimize complications. Background: There are several significant gaps in current studies of the relationship between anti-cancer medications and orthodontic care that call for more investigation. As a result, the main goals of this systematic review and meta-analysis were to summarise and assess the information that was available regarding the effect of radiotherapy and anti-cancer medications on the overall successful completion of an orthodontic treatment plan. Methods: A standardised data extraction form was devised in accordance with the PRISMA guidelines to conduct a systematic review and meta-analysis, with specific criteria implemented for selecting studies with low to moderate risk of bias. Results: Five studies involving different methodologies were selected at the conclusion of the search strategy. The statistical analysis revealed an estimated odds ratio (OR) of 0.31 and relative risk (RR) of 0.48, indicating a statistically significant association between the use of radiotherapy and anti-neoplastic drugs and a noticeable reduction in the successful completion of orthodontic treatment. The heterogeneity analysis showed significant heterogeneity among the studies. Conclusions: This review emphasises that, although orthodontic therapies can still be beneficial for children receiving chemotherapy, the effectiveness of the therapy may be diminished in older populations. The findings further highlight how crucial it is to take cancer therapies into account when planning and managing orthodontic treatment in order to optimise results and reduce problems. [ABSTRACT FROM AUTHOR]

The majority of patients strongly favor the use of aligners in the present time, especially with the advancement in esthetic dentistry. Today's market is flooded with aligner companies, many of which share the same therapeutic ethos. We therefore carried out a systematic review and network meta-analysis to evaluate research that had looked at various aligner materials and attachments and their effect on orthodontic tooth movement in relevant studies. A total of 634 papers were discovered after a thorough search of online journals using keywords such as "Aligners", "Orthodontics", "Orthodontic attachments", "Orthodontic tooth movement", and "Polyethylene" across databases such as PubMed, Web of Science, and Cochrane. The authors individually and in parallel carried out the database investigation, removal of duplicate studies, data extraction, and bias risk. The statistical analysis demonstrated that the type of aligner material had a significant impact on orthodontic tooth movement. The low level of heterogeneity and significant overall effect further support this finding. However, there was little effect of attachment size or shape on tooth mobility. The examined materials were primarily concerned with influencing the physical/physicochemical characteristics of the appliances and not tooth movement directly. Invisalign (Inv) had a higher mean value than the other types of materials that were analyzed, which suggested a potentially greater impact on orthodontic tooth movement. However, its variance value indicated that there was also greater uncertainty associated with the estimate compared to some of the other plastics. These findings could have important implications for orthodontic treatment planning and aligner material selection. Registration: This review protocol was registered on the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42022381466). [ABSTRACT FROM AUTHOR]

A variety of metals and alloys are employed in the field of orthodontics, of which the construction of wires happens to be predominant. Through this systematic review, our primary goal was to review and assess studies focusing on complications that emerged during or directly after the completion of an orthodontic treatment plan. We then used a meta-analysis to determine how these complications affected the patients who were receiving orthodontic treatment. A total of 634 documents were discovered after a thorough search of online journals, and 416 of the papers were initially selected. In the end, 14 papers, including in vitro experiments, literature reviews, comparative analyses, observational studies, and retrospective studies, were chosen that met the requisite inclusion and exclusion criteria. There were difficulties related to orthodontic treatment in all of the studies listed in our systematic review, but their severity varied greatly. The effects of gingival mucosa and root resorption were two of the most often mentioned periodontal problems in this review. More long-term studies are required to confirm the involvement of an orthodontic component in these issues, but the majority of the complications were assessed to initially arise after the treatment plan had begun and to resolve with time. [ABSTRACT FROM AUTHOR]