1. Pre-operative labs: Wasted dollars or predictors of post-operative cardiac and septic events in orthopaedic trauma patients?
- Author
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Lakomkin N, Sathiyakumar V, Dodd AC, Jahangir AA, Whiting PS, Obremskey WT, and Sethi MK
- Subjects
- Aged, Bilirubin metabolism, Cost-Benefit Analysis, Diagnostic Tests, Routine economics, Female, Fractures, Bone blood, Humans, Male, Multiple Trauma blood, Myocardial Infarction blood, Myocardial Infarction prevention & control, Platelet Count methods, Postoperative Complications prevention & control, Predictive Value of Tests, Preoperative Period, Prognosis, Shock, Septic blood, Shock, Septic prevention & control, Surgical Wound Infection blood, Surgical Wound Infection prevention & control, Thromboplastin metabolism, United States, Unnecessary Procedures economics, Diagnostic Tests, Routine statistics & numerical data, Fractures, Bone complications, Multiple Trauma complications, Orthopedic Procedures adverse effects, Orthopedics economics, Postoperative Complications blood
- Abstract
Purpose: As US healthcare expenditures continue to rise, there is significant pressure to reduce the cost of inpatient medical services. Studies have estimated that over 70% of routine labs may not yield clinical benefits while adding over $300 in costs per day for every inpatient. Although orthopaedic trauma patients tend to have longer inpatient stays and hip fractures have been associated with significant morbidity, there is a dearth of data examining pre-operative labs in predicting post-operative adverse events in these populations. The purpose of this study was to assess whether pre-operative labs significantly predict post-operative cardiac and septic complications in orthopaedic trauma and hip fracture patients., Methods: Between 2006 and 2013, 56,336 (15.6%) orthopaedic trauma patients were identified and 27,441 patients (7.6%) were diagnosed with hip fractures. Pre-operative labs included sodium, BUN, creatinine, albumin, bilirubin, SGOT, alkaline phosphatase, white count, hematocrit, platelet count, prothrombin time, INR, and partial thromboplastin time. For each of these labs, patients were deemed to have normal or abnormal values. Patients were noted to have developed cardiac or septic complications if they sustained (1) myocardial infarction (MI), (2) cardiac arrest, or (3) septic shock within 30 days after surgery. Separate regressions incorporating over 40 patient characteristics including age, gender, pre-operative comorbidities, and labs were performed for orthopaedic trauma patients in order to determine whether pre-operative labs predicted adverse cardiac or septic outcomes., Results: 749 (1.3%) orthopaedic trauma patients developed cardiac complications and 311 (0.6%) developed septic shock. Multivariate regression demonstrated that abnormal pre-operative platelet values were significantly predictive of post-operative cardiac arrest (OR: 11.107, p=0.036), and abnormal bilirubin levels were predictive (OR: 8.487, p=0.008) of the development of septic shock in trauma patients. In the hip fracture cohort, abnormal partial thromboplastin time was significantly associated with post-operative myocardial infarction (OR: 15.083, p=0.046), and abnormal bilirubin (OR: 58.674, p=0.002) significantly predicted the onset of septic shock., Conclusions: This is the first study to demonstrate the utility of pre-operative labs in predicting perioperative cardiac and septic adverse events in orthopaedic trauma and hip fracture patients. Particular attention should be paid to haematologic/coagulation labs (platelets, PTT) and bilirubin values., Level of Evidence: Prognostic Level II., (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Published
- 2016
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