1. Positive HLA-B27 and sacroiliitis is not always spondyloarthritis.
- Author
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Aslam F, Chivers FS, Doshi KB, and Chang-Miller A
- Subjects
- Adult, Diagnosis, Differential, Femoral Neoplasms complications, Femoral Neoplasms surgery, HLA-B27 Antigen immunology, Humans, Male, Osteomalacia etiology, Osteomalacia genetics, Osteomalacia immunology, Osteotomy, Predictive Value of Tests, Sacroiliitis etiology, Sacroiliitis genetics, Sacroiliitis immunology, Spondylarthritis genetics, Spondylarthritis immunology, Treatment Outcome, Femoral Neoplasms diagnosis, HLA-B27 Antigen genetics, Osteomalacia diagnosis, Sacroiliitis diagnosis, Spondylarthritis diagnosis
- Abstract
A 36-year-old man was treated for several years with multiple agents for ankylosing spondylitis based on positive human leukocyte antigen-B27 and sacroiliitis. He was also diagnosed with osteoporosis and hypophosphatemia. Over these years, from being an avid runner, he became dependent on a walker for ambulation. The lack of treatment response and the low phosphorus were clues that eventually led to a diagnosis of tumor-induced osteomalacia. This case discusses the importance of not solely relying on genetic markers and sacroiliitis for diagnosing ankylosing spondylitis as other conditions can cause similar presentations., (© 2019 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
- Published
- 2019
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