1. Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases.
- Author
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Wang D, Tabti R, Elderwish S, Abou-Hamdan H, Djehal A, Yu P, Yurugi H, Rajalingam K, Nebigil CG, and Désaubry L
- Subjects
- Gene Expression, Heart Diseases metabolism, Heart Diseases therapy, Humans, Neoplasms metabolism, Neoplasms pathology, Nervous System Diseases metabolism, Nervous System Diseases pathology, Osteoporosis metabolism, Osteoporosis pathology, Prohibitins, Protein Processing, Post-Translational, Repressor Proteins chemistry, Repressor Proteins genetics, Signal Transduction, Heart Diseases pathology, Ligands, Neoplasms therapy, Nervous System Diseases therapy, Osteoporosis therapy, Repressor Proteins metabolism
- Abstract
Over the last three decades, the scaffold proteins prohibitins-1 and -2 (PHB1/2) have emerged as key signaling proteins regulating a myriad of signaling pathways in health and diseases. Small molecules targeting PHBs display promising effects against cancers, osteoporosis, inflammatory, cardiac and neurodegenerative diseases. This review provides an updated overview of the various classes of PHB ligands, with an emphasis on their mechanism of action and therapeutic potential. We also describe how these ligands have been used to explore PHB signaling in different physiological and pathological settings.
- Published
- 2020
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