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A synchrotron radiation X-ray fluorescence microprobe analysis technique was used to scan a slice of the femoral head from its periphery to its center, via cartilage, compact, and spongy zones in order to determine the distribution and the way inorganic substances are lost in bone tissue. The sample preparation and experimental apparatus are described in detail. The quantitative computerized tomography of elemental distribution, such as Ca, P, K, Fe, Zn, Sr, and Pb in bone slice tissue, including cartilage, substantial compact, and substantial spongy, is investigated. Combined with the correlation among P, K, Zn, Sr, and Ca, the route of loss of minerals and the physiological functions of some metal elements in bone are also discussed.

This article deals with an osteoporosis model using New Zealand rabbits in order to study the function of inorganic elements for women patients with osteoporosis. Thirty cases of iliac crests were collected and determined using the neutron activation analysis technique. The results show that the fluorine concentrations in the experimental group are higher than those in the control group and that the magnesium concentrations are significantly lower (p < 0.001), but the concentrations of potassium, sodium, calcium, barium, manganese, and strontium show no significant differences. Combined with the serum biochemical markers of bone formation and resorption, the physiological functions of some metal elements in bone are also discussed.

In order to explore the distribution and the loss way of inorganic substances in bone and to provide scientific basis for prevention and therapy of osteoporosis, Proton Induced X-ray Emission (PIXE) method is used for the determination of elemental concentration in femoral head from five autopsies and seven patients with femoral neck broken, and Synchrotron Radiation X-ray Fluorescence (SRXRF) microprobe analysis technique is used to scan a slice of the femoral head from its periphery to its center, via cartilage, compact and spongy zones. The results show that the concentrations of P, Ca, Fe, Cu, Sr in a control group are higher than those in a patient group, but the concentrations of S, K, Zn, Mn are not significantly different. The quantitative computerized tomography of elemental distribution, such as Ca, P, K, Fe, Zn, Sr and Pb in bone slice tissue including cartilage, substantial compact and substantial spongy, is investigated. Combined with the correlations between P, K, Zn, Sr and Ca, the loss way of minerals and the physiological functions of some metal elements in bone are also discussed. [ABSTRACT FROM AUTHOR]