1. Multiple Myeloma and Paget’s disease with abnormal skull lesions and intracranial hypertension
- Author
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Caravita, T, Siniscalchi, A, Montinaro, E, Bove, R, Zaccagnini, M, De Pascalis, D, Morocutti, A, Brusa, L, Arciprete, F, Cupini, M, Perrotti, A, Palma, E, Fratoni, S, De Simone, R, Iani, C, and de Fabritiis, P
- Subjects
Pathology ,medicine.medical_specialty ,biology ,lcsh:RC633-647.5 ,business.industry ,lcsh:Diseases of the blood and blood-forming organs ,Case Reports ,Hematology ,Settore MED/15 ,medicine.disease ,Skull ,Infectious Diseases ,medicine.anatomical_structure ,Osteoprotegerin ,RANKL ,Paget Disease ,biology.protein ,medicine ,Molecular mechanism ,Differential diagnosis ,business ,Multiple myeloma - Abstract
We report a 73 years old man with a diagnosis of Paget Disease (PD) and symptomatic Multiple Myeloma (MM). Coexistence of MM and PD has rarely been described. PD mimics many of the features of bone destructive process in MM, making differential diagnosis more complicated. In addition, the presence of serious muscolo-skeletal and metabolic complications in both diseases makes management of patients difficult, worsening the prognosis. The comparison of these two diseases has led to the characterization of a common molecular mechanism represented by the receptor activator of nuclear factor-kB ligand (RANKL)/Osteoprotegerin signaling pathway. The improved comprehension of these mechanisms led to the development of new pharmacologic agents (bisphosphonates, cytokines inhibitors) effective for the treatment of these bone diseases.
- Published
- 2012
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