1. [Expression and activity of proteases in metastasis of ovarian cancer].
- Author
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Iunusova NV, Spirina LV, Kondakova IV, Kolomiets LA, Villert AE, and Shpileva OV
- Subjects
- Cysteine Endopeptidases biosynthesis, Female, Gene Expression Regulation, Neoplastic, Humans, Middle Aged, Neoplasm Metastasis, Ovarian Neoplasms pathology, Proteasome Endopeptidase Complex metabolism, Calpain biosynthesis, Ovarian Neoplasms genetics, Pregnancy-Associated Plasma Protein-A biosynthesis, Proteasome Endopeptidase Complex biosynthesis
- Abstract
The total chymotrypsin-like activity of proteasornes, the activity of 20S- and 26S-proteasome pools and calpains, and the expression of metalloproteinase PAPP-A in primary tumors and metastasized tissues were studied in 13 patients with epithelial ovarian cancer. It was shown that initiation of the process of tumor dissemination occurs against the background of active proteolytic processes; A decrease in activity of 26S-proteasomes and total calpain activity and increased expression ofmetalloproteinase PAPP-A in the primary tu mors were found in patients with ascites as compared with patients without ascites. The disease progression after treatment and achieved stabilization were found in patients with decreased activity of intracellular proteases and a high content of PAPP-A in the primary tumors.
- Published
- 2014