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Abstract: Objective:: To compare the effect of HMG and rhFSH on oocyte quality in ICSI cycle. Setting:: Vali-e-Asr university teaching hospital. Method:: Prospective single-blind randomized clinical trial. Subjects:: Sixty women undergoing ovarian stimulation for ICSI were randomized to receive a standard protocol of either HMG or rhFSH in down-regulation cycles. Interventions:: Prior to microinjection, each oocyte was assessed regarding the nuclear maturity, morphology of zona plucida, cytoplasmic appearance and polar body morphology. Fertilization rate was followed. Main outcome:: The percentage of metaphase II oocytes in HMG and rhFSH groups. Statistical analysis:: Statistical analyses were carried out by the Mann–Whitney, Fisher''s exact, χ 2 tests and Student''s t-test. Results:: No significant differences were found between two groups in regard to the demographic data, the ovarian response and pregnancy/implantation rates (P >0.05). The percentage of metaphase II oocytes in HMG and rhFSH groups were 81.3% versus 80.6%, respectively. Conclusions:: There were no significant differences between parameters such as, oocyte quality and percentage of metaphase II oocytes between these two groups. [Copyright &y& Elsevier]

Abstract: Objective: To evaluate the effect of vaginal progesterone as luteal phase support on pregnancy rates in controlled ovarian stimulation and intrauterine insemination cycles in couples with unexplained or mild male factor infertility. Study design: 290 Patients who met the inclusion criteria were included in a prospective randomized controlled trial. All patients underwent controlled ovarian stimulation and intrauterine insemination: 148 patients were randomized to start with a supported cycle and 142 patients with an unsupported cycle. In supported cycles, patients received vaginal progesterone once daily from the day after insemination until 12 weeks of pregnancy or, in non-pregnant women, for 14 days. No progesterone was given during unsupported cycles. The main outcome measures were clinical pregnancy rates per cycle. Results: In total, 148 cycles with luteal phase support and 142 cycles without luteal phase support were performed. The clinical pregnancy rates per cycle were higher for cycles with luteal phase support than for the unsupported cycles (24.3% vs. 14.1% respectively, p =0.027). Conclusion: The use of vaginal suppositories as luteal phase support significantly improved clinical pregnancy rates in controlled ovarian stimulation and intrauterine insemination in patients with unexplained or mild male factor infertility. [Copyright &y& Elsevier]