Author: "O'Farrell F" / Topic: oxidative stress - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"O'Farrell F"' showing total 3 results

Start Over Author "O'Farrell F" Topic oxidative stress

Author: O'Farrell FJ, Hannigan BM, and Barnett Y
Subjects: Cell Line, Humans, Kinetics, T-Lymphocytes drug effects, Tumor Cells, Cultured, Catalase metabolism, Glutathione Peroxidase metabolism, Hydrogen Peroxide pharmacology, Oxidative Stress, Superoxide Dismutase metabolism, T-Lymphocytes physiology
Published: 1996
Full Text: View/download PDF

Author: Barnett YA, Brennan LA, O'Farrell F, and Hannigan BM
Subjects: Cell Division drug effects, Cell Survival drug effects, Cells, Cultured, DNA Damage drug effects, Humans, Hydrogen Peroxide pharmacology, Lymphocytes metabolism, Oxidants pharmacology, Oxidative Stress drug effects
Abstract: The stress response to reactive oxygen species is an important defence system which can reduce their potential to induce biomolecule damage. In this investigation the effect of exposing Molt-3 lymphoblastoid cells or peripheral blood lymphocytes to a non-toxic dose of hydrogen peroxide (10 microM) was studied. Cellular response to a subsequent high dose of hydrogen peroxide (100-200 microM) was assessed by measurement of growth, viability, proliferation and DNA damage (lymphocytes only) and intracellular activities of the enzymes, superoxide dismutase, glutathione peroxidase and catalase (Molt-3 only). The results indicate that pretreatment of lymphocytes with 10 microM hydrogen peroxide can elicit a response which is protective against DNA damage normally inducible in these cells by subsequent exposure to toxic doses of hydrogen peroxide. It appears from the results with Molt-3 cells that altered activities of glutathione peroxidase may contribute to this enhanced resistance to hydrogen peroxide.
Published: 1995

Author: Ya, Barnett, La, Brennan, O'Farrell F, and Bernie Hannigan
Subjects: Oxidative Stress, Cell Survival, Humans, Hydrogen Peroxide, Lymphocytes, Oxidants, Cell Division, Cells, Cultured, DNA Damage
Abstract: The stress response to reactive oxygen species is an important defence system which can reduce their potential to induce biomolecule damage. In this investigation the effect of exposing Molt-3 lymphoblastoid cells or peripheral blood lymphocytes to a non-toxic dose of hydrogen peroxide (10 microM) was studied. Cellular response to a subsequent high dose of hydrogen peroxide (100-200 microM) was assessed by measurement of growth, viability, proliferation and DNA damage (lymphocytes only) and intracellular activities of the enzymes, superoxide dismutase, glutathione peroxidase and catalase (Molt-3 only). The results indicate that pretreatment of lymphocytes with 10 microM hydrogen peroxide can elicit a response which is protective against DNA damage normally inducible in these cells by subsequent exposure to toxic doses of hydrogen peroxide. It appears from the results with Molt-3 cells that altered activities of glutathione peroxidase may contribute to this enhanced resistance to hydrogen peroxide.

Books, media, physical & digital resources

Searchworks