1. Intake of oligoelements with cytarabine or etoposide alters dopamine levels and oxidative damage in rat brain.
- Author
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Guzmán DC, Brizuela NO, Herrera MO, Olguín HJ, Peraza AV, Ruíz NL, and Mejía GB
- Subjects
- Animals, Rats, Male, Lipid Peroxidation drug effects, Dietary Supplements, Glutathione metabolism, Etoposide pharmacology, Oxidative Stress drug effects, Cytarabine pharmacology, Dopamine metabolism, Rats, Wistar, Brain metabolism, Brain drug effects
- Abstract
Research on the relationships between oligoelements (OE) and the development of cancer or its prevention is a field that is gaining increasing relevance. The aim was to evaluate OE and their interactions with oncology treatments (cytarabine or etoposide) to determine the effects of this combination on biogenic amines and oxidative stress biomarkers in the brain regions of young Wistar rats. Dopamine (DA), 5-Hydroxyindoleacetic acid (5-Hiaa), Glutathione (Gsh), Tiobarbituric acid reactive substances (TBARS) and Ca
+2 , Mg+2 ATPase enzyme activity were measured in brain regions tissues using spectrophometric and fluorometric methods previously validated. The combination of oligoelements and cytarabine increased dopamine in the striatum but decreased it in cerebellum/medulla-oblongata, whereas the combination of oligoelements and etoposide reduced lipid peroxidation. These results suggest that supplementation with oligoelements modifies the effects of cytarabine and etoposide by redox pathways, and may become promising therapeutic targets in patients with cancer., (© 2024. The Author(s).)- Published
- 2024
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