1. Preventive effects of zinc against psychological stress-induced iron dyshomeostasis, erythropoiesis inhibition, and oxidative stress status in rats.
- Author
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Li Y, Zheng Y, Qian J, Chen X, Shen Z, Tao L, Li H, Qin H, Li M, and Shen H
- Subjects
- Animals, Cerebral Cortex drug effects, Cerebral Cortex metabolism, Chlorides administration & dosage, Chlorides pharmacology, Corticosterone blood, Dietary Supplements, Erythropoiesis physiology, Glutathione, Hippocampus drug effects, Hippocampus metabolism, Homeostasis drug effects, Homeostasis physiology, Iron blood, Liver drug effects, Liver metabolism, Male, Malondialdehyde metabolism, Neostriatum drug effects, Neostriatum metabolism, Oxidative Stress physiology, Rats, Rats, Sprague-Dawley, Spleen drug effects, Spleen metabolism, Stress, Psychological blood, Superoxide Dismutase metabolism, Zinc administration & dosage, Zinc Compounds administration & dosage, Zinc Compounds pharmacology, Erythropoiesis drug effects, Iron metabolism, Oxidative Stress drug effects, Stress, Psychological physiopathology, Zinc pharmacology
- Abstract
Psychological stress (PS) could cause decreased iron absorption and iron redistribution in body resulting in low iron concentration in the bone marrow and inhibition of erythropoiesis. In the present study, we investigated the effect of zinc supplementation on the iron metabolism, erythropoiesis, and oxidative stress status in PS-induced rats. Thirty-two rats were divided into two groups randomly: control group and zinc supplementation group. Each group was subdivided into two subgroups: control group and PS group. Rats received zinc supplementation before PS exposure established by a communication box. We investigated the serum corticosterone (CORT) level; iron apparent absorption; iron contents in liver, spleen, cortex, hippocampus, striatum, and serum; hematological parameters; malondialdehyde (MDA); reduced glutathione (GSH); and superoxide dismutase (SOD). Compared to PS-treated rats with normal diet, the PS-treated rats with zinc supplementation showed increased iron apparent absorption, serum iron, hemoglobin, red blood cell, GSH, and SOD activities; while the serum CORT; iron contents in liver, spleen, and regional brain; and MDA decreased. These results indicated that dietary zinc supplementation had preventive effects against PS-induced iron dyshomeostasis, erythropoiesis inhibition, and oxidative stress status in rats.
- Published
- 2012
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