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11 results on '"McDowall DG"'

1. Brain-surface oxygen tension and cerebral cortical blood flow during hemorrhagic and drug-induced hypotension in the cat.

Author

Maekawa T, McDowall DG, and Okuda Y

Subjects
Anesthesia, Inhalation, Animals, Cats, Cerebral Cortex metabolism, Female, Halothane, Male, Methoxyflurane, Microcirculation drug effects, Nitroprusside pharmacology, Trimethaphan pharmacology, Cerebral Cortex blood supply, Cerebrovascular Circulation drug effects, Hypotension physiopathology, Hypotension, Controlled, Oxygen blood
Published
1979
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2. I.c.p. increases with 50% nitrous oxide in oxygen in severe head injuries during controlled ventilation.

Author

Moss E and McDowall DG

Subjects
Anesthesia, Inhalation, Craniocerebral Trauma therapy, Humans, Physical Therapy Modalities, Random Allocation, Stimulation, Chemical, Craniocerebral Trauma physiopathology, Intermittent Positive-Pressure Ventilation, Intracranial Pressure drug effects, Nitrous Oxide pharmacology, Oxygen pharmacology, Positive-Pressure Respiration
Abstract

In a randomized trial nitrous oxide 50% in oxygen (Entonox) or oxygen 100% was given during chest physiotherapy on 23 occasions to three mechanically ventilated patients with severe head injuries. Intracranial pressure (i.c.p.) increased by 22.7 mm Hg (SD 10.62) during chest physiotherapy with Entonox, compared with 10.5 mm Hg (SD 10.4) with oxygen 100% (P greater than 0.02). A further nine mechanically ventilated patients with severe head injuries were given Entonox without chest physiotherapy. There was a mean increase in i.c.p. of 3.8 mm Hg (SD 2.4) (P less than 0.001) when Entonox was given, and a mean decrease of 4.6 mm Hg (SD 2.8) when the nitrous oxide was withdrawn. End-tidal carbon dioxide concentration showed almost no change during nitrous oxide administration (decrease of 0--0.1%). We conclude that nitrous oxide causes an increase in i.c.p. in patients with severe head injuries and exacerbates the increases in i.c.p. occurring during chest physiotherapy.

Published
1979
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8. ANAESTHESIA IN A PRESSURE CHAMBER.

Author

MCDOWALL DG

Subjects
Animals, Dogs, Anesthesia, Atmospheric Pressure, Biomedical Research, Blood Gas Analysis, Blood Pressure, Chloroform, Electrocardiography, Electroencephalography, Equipment and Supplies, Explosions, Fires, Halothane, Hyperbaric Oxygenation, Metabolism, Methoxyflurane, Nitrous Oxide, Operating Rooms, Oxygen, Pulse, Research
Published
1964
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11. Interrelationships between blood oxygen tensions and cerebral blood flow.

Author

McDowall DG

Subjects
Animals, Blood Flow Velocity, Blood Pressure, Carbon Dioxide blood, Cerebral Cortex metabolism, Dogs, Electrocardiography, Hyperbaric Oxygenation, Hypoxia, Oximetry, Oxygen metabolism, Cerebral Cortex blood supply, Cerebrovascular Circulation, Oxygen blood, Regional Blood Flow
Published
1966

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