1. A phase I study of paclitaxel for mobilization of peripheral blood progenitor cells.
- Author
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Burtness BA, Psyrri A, Rose M, D'Andrea E, Staugaard-Hahn C, Henderson-Bakas M, Clark MB, Mechanic S, Krause D, Snyder E, Cooper RB, Abrantes J, Corringham R, Deisseroth A, and Cooper DL
- Subjects
- Adult, Antigens, CD34, Blood Cell Count, Hematopoietic Stem Cells drug effects, Hematopoietic Stem Cells pathology, Humans, Infusions, Intravenous, Middle Aged, Antineoplastic Agents, Phytogenic administration & dosage, Hematopoietic Stem Cell Mobilization, Hematopoietic Stem Cell Transplantation, Paclitaxel administration & dosage
- Abstract
We conducted a phase I trial to determine the dose and schedule of paclitaxel, when given together with filgrastim, which would optimally promote mobilization of stem cells with tolerable toxicity. Dose escalation began at 275 mg/m2 3 h infusion. Dose-limiting neuropathy was observed at the 300 mg/m2 dose level. A second dose escalation was conducted utilizing 24 h infusion schedules, beginning at 225 mg/m2. Dose escalation was continued by 25 mg/m2 increments to 300 mg/m2, at which dose neuropathy was again dose-limiting. The recommended dose and schedule of paclitaxel for the purpose of mobilization of stem cells, when given together with filgrastim, are 275 mg/m2 as a 24 h infusion. The median stem cell yield after this dose of paclitaxel was 6.6 x 10(6) CD34+ cells/kg/apheresis (range 3.6 x 10(6)-7.7 x 10(6)).
- Published
- 1999
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