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Your search keyword '"PAF-acetylhydrolase (PAF-AH)"' showing total 2 results
Start Over Descriptor "PAF-acetylhydrolase (PAF-AH)" Topic paf acetylhydrolase
2 results on '"PAF-acetylhydrolase (PAF-AH)"'

1. Interleukin-1beta stimulates platelet-activating factor production in U-937 cells modulating both its biosynthetic and catabolic enzymes.

Author

Vlachogianni, Ioanna C., Nomikos, Tzortzis, Fragopoulou, Elizabeth, Stamatakis, George M., Karantonis, Haralambos C., Antonopoulou, Smaragdi, and Demopoulos, Constantinos A.

Subjects
*INTERLEUKIN-1, *PLATELET activating factor, *BIOSYNTHESIS, *CHOLINEPHOSPHOTRANSFERASE, *ACETYLCOENZYME A, *NF-kappa B
Abstract

Highlights: [•] IL-1β induces a time dependent synthesis of intracellular PAF in U-937. [•] The last enzymes of both biosynthetic routes of PAF are activated by IL-1β. [•] PAF-AH is crucial for the maintenance of intracellular PAF levels in U-937. [ABSTRACT FROM AUTHOR]

Published
2013
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2. Relationship between platelet activating factor acetylhydrolase activity and apolipoprotein B levels in patients with peanut allergy

Author

Areej Adil, Boris Perelman, and Peter Vadas

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Allergy, PAF acetylhydrolase, Apolipoprotein B, Peanut allergy, PAF-acetylhydrolase (PAF-AH), Phospholipid, Short Report, chemistry.chemical_compound, Internal medicine, medicine, Immunology and Allergy, Low density lipoprotein (LDL), Anaphylaxis, Platelet-activating factor (PAF), biology, business.industry, General Medicine, respiratory system, Apolipoprotein B (apoB), medicine.disease, Endocrinology, chemistry, Low-density lipoprotein, Immunology, biology.protein, lipids (amino acids, peptides, and proteins), business, Lipoprotein
Abstract

Background Platelet-activating factor (PAF) is a highly potent phospholipid mediator responsible for the life-threatening manifestations of anaphylaxis. PAF acetylhydrolase (PAF-AH) inactivates PAF and protects against severe anaphylaxis whereas deficiency of PAF-AH predisposes to severe or fatal anaphylaxis. Determinants of PAF-AH activity have not been studied in patients with peanut allergy. Objectives To determine whether plasma PAF-AH activity in patients with peanut allergy is related to formation of circulating complexes with apolipoprotein B (apoB) the main surface protein on low density lipoprotein particles. Methods Plasma PAF-AH activity and apoB concentrations were measured in 63 peanut allergic patients (35 boys, 28 girls, ages 2 – 19 years). ApoB concentration was measured immunoturbidimetrically using goat anti-human apoB. The correlation between PAF-AH activity and apoB concentration was determined. Results A positive correlation was found between PAF-AH activity and apoB concentration (r2 = 0.59, P

Published
2014

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