Search

Your search keyword '"Genitiempo M"' showing total 3 results
Start Over Author "Genitiempo M" Topic pain
3 results on '"Genitiempo M"'

1. Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department.

Author

Buccelletti F, Marsiliani D, Zuccalà G, Iacomini P, Proietti L, Pola E, Zirio G, Genitiempo M, Marrocco R, Conti C, Brunetti C, Rocchi L, Merendi G, D'Aurizio G, Gilardi E, and Franceschi F

Subjects
Acute Pain diagnosis, Acute Pain epidemiology, Adult, Aged, Analgesics, Non-Narcotic administration & dosage, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Cohort Studies, Cross-Sectional Studies, Drug Combinations, Female, Humans, Male, Middle Aged, Pain epidemiology, Pain Measurement drug effects, Pain Measurement methods, Prospective Studies, Acetaminophen administration & dosage, Codeine administration & dosage, Emergency Service, Hospital, Ketorolac therapeutic use, Pain diagnosis, Pain drug therapy, Pain Management methods
Abstract

Objective: Paracetamol /codeine has shown a strong analgesic activity in several studies conducted among different kind of subjects, including those with trauma. Nevertheless, its efficacy in patients accessing the Emergency Department (ED) for different kind of pain has never been tested., Patients and Methods: This is a cross-sectional, observational, prospective, cohort study. Inclusion criteria were patients > 18 year old presenting to the ED for localized traumatic or inflammatory pain involving only extremities. Numeric scale (NRS) was recorded thirty minutes and two hours after the administration of the analgesic therapy, consisting of 15 mg of ketorolac or 1000 mg/60 mg of paracetamol/ codeine, both orally., Results: Two-hundred patients were consecutively enrolled; 87 were treated with paracetamol/codeine and 113 with ketorolac. The combination paracetamol/codeine resulted to be not inferior to ketorolac in non-traumatic pain group and trauma group (p = 0.635 and p = 0.482, respectively). Compared to ketorolac, the combination paracetamol/codeine exerted a significantly higher analgesic activity in patients with fractures and muscular pain (p = 0.044) and was more effective in acute pain (p = 0.002), with a significant effect two hours after the administration (p = 0.029)., Conclusions: Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain. Those results play in favor of the use of the combination paracetamol/codeine in patients accessing the ED for non-traumatic or traumatic pain of the extremities.

Published
2014

2. Kyphoplasty vs conservative treatment: a case-control study in 110 post-menopausal women population. Is kyphoplasty better than conservative treatment?

Author

Colangelo, D., Nasto, L. A., Genitiempo, M., Formica, V. M., Giovanni Autore, Pambianco, V., Tamburrelli, F. C., Cerulli, G., Pola, E., Colangelo, D, Nasto, La, Genitiempo, M, Formica, Vm, Autore, G, Pambianco, V, Tamburrelli, Fc, Cerulli, G, and Pola, E

Subjects
Aged, 80 and over, Braces, Pain, Conservative treatment, Middle Aged, Vertebral compression fractures, Settore MED/33 - MALATTIE APPARATO LOCOMOTORE, Treatment Outcome, Case-Control Studies, Surveys and Questionnaires, Quality of Life, Humans, Minimally Invasive Surgical Procedures, Spinal Fractures, Osteoporosis, Female, Kyphoplasty, Kyphosis, Osteoporosis, Postmenopausal, Osteoporotic Fractures, Clinical out-COMES, Aged, Pain Measurement, Retrospective Studies
Abstract

Osteoporosis is a highly prevalent disease worldwide. Consequences of vertebral osteoporotic fractures include pain and progressive vertebral collapse resulting in spinal kyphosis, decreased quality of life, disability and mortality. Minimally invasive procedures represent an advance to the treatment of osteoporotic VCFs. Despite encouraging results reported by many authors, surgical intervention in an osteoporotic spine is fraught with difficulties. Advanced patients age and comorbidities are of great concern. PATIENTS AND METHODS: We designed a retrospective case-control study on 110 post-menopausal women consecutively visited at our institution. Study population was split in a surgical and a conservative cohort, according to the provided treatment. RESULTS: Kyphoplasty treated patients had lower back pain VAS scores at 1 month as compared with conservatively treated patients (p < 0.05). EQ5D validated questionnaire also showed a better quality of life at 1 month for surgically treated patients (p < 0.05). SF-12 scores showed greater improvements at 1 month and 3 months with statistically significant difference between the two groups just at 3 months (p < 0.05). At 12 months, scores from all scales were not statistically different between the two cohorts, although surgically treated patients showed better trends than conservatively treated patients in pain and quality of life. Kyphoplasty was able to restore more than 54.55% of the original segmental kyphosis, whereas patients in conservative cohort lost 6.67% of the original segmental kyphosis on average. CONCLUSIONS: Kyphoplasty is a modern minimal invasive surgery, allowing faster recovery than bracing treatment. It can avoid the deformity in kyphosis due to VCF. In fact, the risk to develop a new vertebral fracture after the first one is very high.

Published
2015

3. Paracetamol-codeine compared to ketorolac for pain control in the Emergency Department

Author

Buccelletti, F., Marsiliani, D., Zuccalà, G., Iacomini, P., Proietti, L., Pola, E., Zirio, G., Genitiempo, M., Marrocco, R., Conti, C., Brunetti, C., Rocchi, L., Merendi, G., D Aurizio, G., Gilardi, E., Francesco Franceschi, Buccelletti, Francesco, Marsiliani, Davide, Zuccala', Giuseppe, Iacomini, Paolo, Proietti, Luca, Pola, Enrico, Zirio, Gianfranco, Genitiempo, Maurizio, Marrocco, Raffaella, Conti, Carla, Brunetti, Claudia, Rocchi, Lorenzo, Merendi, Gianfranco, D'Aurizio, Gabriella, Gilardi, Emanuele, and Franceschi, Francesco

Subjects
Adult, Male, NSAIDs, Codeine, Settore MED/09 - MEDICINA INTERNA, Anti-Inflammatory Agents, Non-Steroidal, Pain, Analgesics, Non-Narcotic, Middle Aged, Trauma, Acute Pain, NSAID, Cohort Studies, Drug Combinations, Paracetamol, Cross-Sectional Studies, Humans, Pain Management, Female, Prospective Studies, Emergency Service, Hospital, Ketorolac, Acetaminophen, Aged, Pain Measurement
Abstract

OBJECTIVE: Paracetamol /codeine has shown a strong analgesic activity in several studies conducted among different kind of subjects, including those with trauma. Nevertheless, its efficacy in patients accessing the Emergency Department (ED) for different kind of pain has never been tested. PATIENTS AND METHODS: This is a cross-sectional, observational, prospective, cohort study. Inclusion criteria were patients > 18 year old presenting to the ED for localized traumatic or inflammatory pain involving only extremities. Numeric scale (NRS) was recorded thirty minutes and two hours after the administration of the analgesic therapy, consisting of 15 mg of ketorolac or 1000 mg/60 mg of paracetamol/ codeine, both orally. RESULTS: Two-hundred patients were consecutively enrolled; 87 were treated with paracetamol/codeine and 113 with ketorolac. The combination paracetamol/codeine resulted to be not inferior to ketorolac in non-traumatic pain group and trauma group (p = 0.635 and p = 0.482, respectively). Compared to ketorolac, the combination paracetamol/codeine exerted a significantly higher analgesic activity in patients with fractures and muscular pain (p = 0.044) and was more effective in acute pain (p = 0.002), with a significant effect two hours after the administration (p = 0.029). CONCLUSIONS: Paracetamol/codeine is equivalent to ketorolac in non-traumatic pain and post-traumatic pain, but is superior in acute pain and in patients with fractures and muscular pain. Those results play in favor of the use of the combination paracetamol/codeine in patients accessing the ED for non-traumatic or traumatic pain of the extremities.

Catalog

Books, media, physical & digital resources
See catalog results