1. Effects of norepinephrine on the electrical activities of pain-related neurons in the rat nucleus accumbens.
- Author
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Zhang D, Yang DX, Yang CX, Zhang GW, Gao HR, Zhai Y, Jiao RS, Zhang Y, Zhang H, Liang Y, and Xu MY
- Subjects
- Animals, Electric Stimulation, Female, Male, Microelectrodes, Norepinephrine pharmacology, Phentolamine pharmacology, Rats, Rats, Wistar, Sciatic Nerve metabolism, Neurons metabolism, Norepinephrine metabolism, Nucleus Accumbens metabolism, Pain physiopathology
- Abstract
This study examined the effects of norepinephrine (NE) and phentolamine on the electrical activities of pain-excited neurons (PENs) and pain-inhibited neurons (PINs) in the nucleus accumbens (NAc) of Wistar rats. Trains of electric pulses applied to the right sciatic nerve were used to provide noxious stimulation, and the discharges of PENs and PINs were recorded using a glass microelectrode. Our results revealed that in response to noxious stimulation, NE decreases the evoked discharge frequency of PENs and increases the evoked discharge frequency of PINs in the NAc of healthy rats, whereas phentolamine produced opposite responses. These results demonstrate that NE is involved in the modulation of nociceptive information transmission in the NAc.
- Published
- 2011
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