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1. Morphine and its potentiated form: effects on pain sensitivity in rats.

Author

Berchenko OG, Vorob'eva TM, and Geiko VV

Subjects
Animals, Dose-Response Relationship, Drug, Male, Rats, Substance Withdrawal Syndrome, Analgesics, Opioid pharmacology, Morphine pharmacology, Pain Threshold drug effects
Abstract

We studied the effects of morphine and its potentiated form on nociceptive thresholds in rats with the morphine withdrawal syndrome. Repeated combination (bipathic) treatment with morphine and its potentiated form increased nociceptive threshold and, therefore, activated the nociceptive system in the brain.

Published
2003
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