1. Palladium(II)-Stabilized Pyridine-2-Diazotates: Synthesis, Structural Characterization, and Cytotoxicity Studies.
- Author
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Tskhovrebov AG, Vasileva AA, Goddard R, Riedel T, Dyson PJ, Mikhaylov VN, Serebryanskaya TV, Sorokoumov VN, and Haukka M
- Subjects
- Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Azo Compounds chemistry, Cell Line, Tumor, Cell Proliferation drug effects, Cell Survival drug effects, Coordination Complexes chemical synthesis, Coordination Complexes chemistry, Crystallography, X-Ray, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, HEK293 Cells, Humans, Models, Molecular, Molecular Structure, Palladium chemistry, Pyridines chemistry, Structure-Activity Relationship, Antineoplastic Agents pharmacology, Azo Compounds pharmacology, Coordination Complexes pharmacology, Palladium pharmacology, Pyridines pharmacology
- Abstract
Well-defined diazotates are scarce. Here we report the synthesis of unprecedented homoleptic palladium(II) diazotate complexes. The palladium(II)-mediated nitrosylation of 2-aminopyridines with NaNO
2 results in the formation of metal-stabilized diazotates, which were found to be cytotoxic to human ovarian cancer cells.- Published
- 2018
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