1. New triterpenoid saponins from the steaming treated roots of Panax notoginseng.
- Author
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Gu CZ, Qiao YJ, Wang D, Zhu HT, Yang CR, Xu M, and Zhang YJ
- Subjects
- Antineoplastic Agents, Phytogenic chemistry, Antineoplastic Agents, Phytogenic pharmacology, Cell Line, Tumor, Drug Screening Assays, Antitumor methods, Humans, Magnetic Resonance Spectroscopy, Molecular Structure, Saponins pharmacology, Spectrometry, Mass, Electrospray Ionization, Steam, Triterpenes pharmacology, Dammaranes, Panax notoginseng chemistry, Plant Roots chemistry, Saponins chemistry, Triterpenes chemistry
- Abstract
Further phytochemical investigation of the steaming treated roots of Panax notoginseng (Araliaceae) led to the identification of two new dammarane-type triterpenoid saponins, notoginsenoside SP20 (1) and SP21 (2). In addition, a pair of new phenolic glycosides (3a and 3b) was also isolated together with two known compounds. Their structures were elucidated by HRESIMS, 1D- and 2D-NMR spectra. Compounds 1 and 2 showed no in vitro cytotoxicity against five human cancer cell lines (HL-60, SMMC-7712, A-549, MCF-9 and SW480).
- Published
- 2018
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