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Start Over Topic pancreatic neoplasms
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1. HERG1 functions as an oncogene in pancreatic cancer and is downregulated by miR-96.

Author

Feng J, Yu J, Pan X, Li Z, Chen Z, Zhang W, Wang B, Yang L, Xu H, Zhang G, and Xu Z

Subjects
Aged, Animals, Apoptosis genetics, Cell Line, Tumor, Cell Proliferation genetics, Down-Regulation, ERG1 Potassium Channel, Ether-A-Go-Go Potassium Channels metabolism, Female, Gene Expression, Genes, Tumor Suppressor, Heterografts, Humans, Male, Mice, Mice, Inbred BALB C, Mice, Nude, MicroRNAs metabolism, Pancreatic Neoplasms metabolism, Prognosis, Pancreatic Neoplasms, Ether-A-Go-Go Potassium Channels genetics, MicroRNAs genetics, Pancreatic Neoplasms genetics
Abstract

Pancreatic cancer is an aggressive malignancy with an extremely poor prognosis. The human ether-a-go-go-related potassium channel (HERG1) is a human rapid delayed rectifier, which is involved in many crucial cellular events. In this article, we find that HERG1 expression is dramatically increased both in pancreatic cancer tissues and cell lines, and that increased HERG1 expression is significantly related to the development of pancreatic cancer. HERG1 silencing in pancreatic cancer-derived cell lines PANC-1 and CFPAC-1 strongly inhibits their malignant capacity in vitro as well as tumorigenicity and metastasis in nude mice. In addition, HERG1 is identified as a direct target of miR-96, which is downregulated in pancreatic cancer tissues and cell lines. Ectopic expression of miR-96 represses the HERG1 expression in pancreatic cancer and significantly inhibits malignant behavior of pancreatic cancer cells in vitro and in vivo. Collectively, our findings suggest that miR-96 acts as a tumor suppressor in pancreatic cancer and may therefore serve as a useful therapeutic target for the development of new anticancer therapy.

Published
2014
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2. Antenatal manifestation of congenital pancreatoblastoma in a fetus with Beckwith-Wiedemann syndrome

Author

G. P. e. l. i. z. z. o., . G. Conoscenti, Vesce, Fortunato, Guerrini, . P., Cavazzini AUTHOR CORRECTIONS: Two of the author names in the above paper, . L., published in the April issue of Prenatal Diagnosis, The correct names are Fortunato Vesce, were supplied e. r. r. o. n. e. o. u. s. l. y., and The authors would like to apologise for any inconvenience caused, Pietro G. u. e. r. r. i. n. i.

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, Pediatrics, medicine.medical_specialty, Pathology, Pancreatic disease, Beckwith-Wiedemann Syndrome, Pregnancy, High-Risk, Pancreatoblastoma, Beckwith–Wiedemann syndrome, Prenatal diagnosis, Ultrasonography, Prenatal, Pregnancy, Neoplasms, medicine, complications/pathology/ultrasonography, Humans, Prenatal, Cyst, Tomography, Genetics (clinical), Ultrasonography, Fetus, business.industry, Infant, Newborn, Obstetrics and Gynecology, Infant, complications/surgery/ultrasonography, Neoplasms, Germ Cell and Embryonal, Middle Aged, medicine.disease, complications/pathology/ultrasonography, Female, Humans, Infant, Newborn, Maternal Age, Middle Aged, Neoplasms, Germ Cell and Embryonal, complications/surgery/ultrasonography, Pancreatic Neoplasms, complications/surgery/ultrasonography, Pregnancy, Pregnancy, High-Risk, Tomography, X-Ray Computed, Treatment Outcome, Ultrasonography, Newborn, Uniparental disomy, X-Ray Computed, Pancreatic Neoplasms, medicine.anatomical_structure, Treatment Outcome, Female, High-Risk, Pancreas, business, Tomography, X-Ray Computed, Maternal Age
Abstract

Antenatal detection of an isolated abdominal cyst was found to be a pancreatoblastoma in a female fetus with Beckwith-Wiedemann syndrome. Prenatal and post-natal features and management of this very rare tumour are discussed. Molecular investigation disclosed a mosaic paternal 11p15 uniparental disomy in the tumoral cells. The prognosis of a congenital pancreatoblastoma is good if complete surgical excision is achieved. However, the association with Beckwith-Wiedemann syndrome requires a prolonged follow-up because of the increased risk of developing malignant tumours.

Published
2003