1. Prevalence and concordance of human papillomavirus infection at multiple anatomic sites among HIV-infected women from Chennai, India.
- Author
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Menezes, Lynette J., Poongulali, Selvamuthu, Tommasino, Massimo, Lin, Hui-Yi, Kumarasamy, Nagalingeswaran, Fisher, Kate J., Saravanan, Shanmugam, Gheit, Tarik, Ezhilarasi, Chandrasekaran, Jeeva, Arumugham, Lu, Beibei, and Giuliano, Anna R.
- Subjects
THERAPEUTICS ,HIV infections ,HIV-positive women ,DISEASE prevalence ,POLYMERASE chain reaction ,BIOLOGICAL specimens ,HIV infection complications ,HIV infection epidemiology ,ANUS ,CERVIX uteri ,DNA ,LONGITUDINAL method ,PAPILLOMAVIRUS diseases ,PAPILLOMAVIRUSES ,HUMAN sexuality ,SOCIOECONOMIC factors ,OROPHARYNX ,DISEASE complications - Abstract
Human papillomavirus (HPV) infection at the cervix, anus and oropharynx has been rarely concurrently estimated among HIV-infected women. Using multiplex polymerase chain reaction testing, we prospectively evaluated HPV genotype distribution across three anatomic sites among 50 eligible HIV-infected women from Chennai, India, who provided biological specimens and answered a sexual behaviour questionnaire. We also assessed clinical and behavioural factors related to HPV prevalence. Oncogenic HPV prevalence was comparable between the anus and cervix at 52.2% and 52.0% and lower at the oropharynx at 13.2%; 78% of women with a cervical HPV infection had the same type in the anus. Newly acquired oncogenic HPV infections were lower at cervix (24%) than anus (35%) at three months. 'Any type' cervical HPV prevalence was higher among women with low education and less than five years since HIV diagnosis. CD4+ count and antiretroviral therapy status were not associated with HPV prevalence at the three anatomic sites; however, enrolment cervical HPV16 prevalence was elevated among women with nadir CD4+ <200 cells/µL and enrolment CD4+ <350 cells/µL. Regular cervical screening is essential in HIV-infected Indian women irrespective of CD4+ count and antiretroviral therapy status. Additional research clarifying the natural history of anal HPV infection is also needed in this population. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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