1. Protective effect of melatonin against herbicides-induced hepatotoxicity in rats
- Author
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Lecio Leone Almeida, Valdemiro Amaro da Silva Junior, Valéria Wanderley Teixeira, Leucio Duarte Vieira Filho, Giovanna Silva Girão Nobre Pitombeira, Álvaro Aguiar Coelho Teixeira, and Joaquim Evêncio Neto
- Subjects
Paper ,0303 health sciences ,medicine.medical_specialty ,Antioxidant ,Thiobarbituric acid ,Health, Toxicology and Mutagenesis ,medicine.medical_treatment ,Albumin ,Glutathione ,Toxicology ,medicine.disease_cause ,Melatonin ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,Paraquat ,chemistry ,Internal medicine ,medicine ,Alkaline phosphatase ,030217 neurology & neurosurgery ,Oxidative stress ,030304 developmental biology ,medicine.drug - Abstract
Exposure to the herbicides Paraquat and Roundup® may cause cell lesions due to an increase in oxidative stress levels in different biological systems, even in the liver. The aim of this study was to analyze the effect of melatonin on liver of rats exposed to herbicides. A total of 35 rats were randomly divided into seven equal-sized groups: control, Paraquat, Roundup®, Paraquat + Roundup®, Paraquat + melatonin, Roundup® + melatonin, and Paraquat + Roundup® + melatonin. Samples of blood and hepatic tissue were collected at the end of the seventh day of exposure and treatment with melatonin. Body weight, hematological parameters, and histopathological, biochemical analyses and determination of oxidative stress levels in liver were evaluated. Body weight was compromised (P
- Published
- 2020