1. Plasmodium yoelii: the effect of second blood meal and anti-sporozoite antibodies on development and gene expression in the mosquito vector, Anopheles stephensi
- Author
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Luis Lopes, A.P. Silva, Henrique Silveira, Patrícia Abrantes, and V.E. doRosario
- Subjects
Immunology ,Antibodies, Protozoan ,Plasmodium ,Polymerase Chain Reaction ,Mice ,parasitic diseases ,Anopheles ,medicine ,Parasite hosting ,Animals ,Anopheles stephensi ,biology ,Gene Expression Profiling ,fungi ,Gene Expression Regulation, Developmental ,General Medicine ,Feeding Behavior ,Plasmodium yoelii ,DNA, Protozoan ,biology.organism_classification ,medicine.disease ,Blood meal ,Virology ,Insect Vectors ,Rats ,Circumsporozoite protein ,Infectious Diseases ,Blood ,Sporozoites ,biology.protein ,Parasitology ,Female ,Antibody ,Sequence Analysis ,Malaria ,RNA, Protozoan - Abstract
The sporogonic development of the malaria parasite takes place in the mosquito and a wide range of factors modulates it. Among those, the contents of the blood meal can influence the parasite development directly or indirectly through the mosquito response to the infection. We have studied the effect of a second blood meal in previously infected mosquitoes and the effect of anti-sporozoite immune serum on parasite development and mosquito response to the infection. The prevalence and intensity of infection and gene expression of both Plasmodium yoelii and Anopheles stephensi was analyzed. We verified that a second blood meal and its immune status interfere with parasite development and with Plasmodium and mosquito gene expression.
- Published
- 2006