1. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease.
- Author
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Brochard V, Combadière B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D, Callebert J, Launay JM, Duyckaerts C, Flavell RA, Hirsch EC, and Hunot S
- Subjects
- Aged, Aged, 80 and over, Animals, CD4-Positive T-Lymphocytes cytology, Cell Death physiology, Disease Models, Animal, Dopamine metabolism, Fas Ligand Protein genetics, Fas Ligand Protein metabolism, Homeodomain Proteins genetics, Homeodomain Proteins metabolism, Humans, Immune System physiology, Interferon-gamma metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Neurons cytology, Neurons metabolism, Neurons pathology, Brain cytology, Brain immunology, Brain pathology, CD4-Positive T-Lymphocytes immunology, Nerve Degeneration immunology, Nerve Degeneration pathology, Parkinson Disease immunology, Parkinson Disease pathology, Parkinsonian Disorders immunology, Parkinsonian Disorders pathology
- Abstract
Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of dopamine-containing neurons. Mounting evidence suggests that dopaminergic cell death is influenced by the innate immune system. However, the pathogenic role of the adaptive immune system in PD remains enigmatic. Here we showed that CD8+ and CD4+ T cells but not B cells had invaded the brain in both postmortem human PD specimens and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD during the course of neuronal degeneration. We further demonstrated that MPTP-induced dopaminergic cell death was markedly attenuated in the absence of mature T lymphocytes in 2 different immunodeficient mouse strains (Rag1-/- and Tcrb-/- mice). Importantly, similar attenuation of MPTP-induced dopaminergic cell death was seen in mice lacking CD4 as well as in Rag1-/- mice reconstituted with FasL-deficient splenocytes. However, mice lacking CD8 and Rag1-/- mice reconstituted with IFN-gamma-deficient splenocytes were not protected. These data indicate that T cell-mediated dopaminergic toxicity is almost exclusively arbitrated by CD4+ T cells and requires the expression of FasL but not IFNgamma. Further, our data may provide a rationale for targeting the adaptive arm of the immune system as a therapeutic strategy in PD.
- Published
- 2009
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