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Your search keyword '"Spehar Uroic A"' showing total 2 results
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2 results on '"Spehar Uroic A"'

1. Severe virilization in adolescent girl with Sertoli-Leydig cell tumor – case report and review of the literature

Author

Nataša Rojnić Putarek, Nevena Krnić, Lana Škrgatić, Mihajlo Strelec, Marija Macan, Anita Spehar Uroic, Vesna Kušec, and Katja Dumić Kubat

Subjects
Pediatrics, medicine.medical_specialty, business.industry, medicine.drug_class, Virilization, Androgen, Sertoli-Leydig cell tumor, Sex cord-stromal tumor, Alpha fetoprotein, Pediatrics, Perinatology and Child Health, Medicine, Stage (cooking), medicine.symptom, business, Alpha-fetoprotein, Pathological, Testosterone, Sertoli-Leydig Cell Tumor, Sex Cord-Stromal Tumor
Abstract

Objective – The aim was to report a case of a 17-year-old girl with marked virilization and secondary amenorrhea due to androgen producing Sertoli-Leydig cell tumor (SLCT). We also provided a brief review of the literature with insight into clinical picture, pathological features and treatment of patients with this rare tumor. Case report − We present a 17-year-old girl with SLCT, who developed clinical symptoms of severe virilization. The tumor secreted testosterone and alpha fetoprotein (AFP). The imaging revealed tumor of the right ovary which histologically corresponded to intermediate-grade SLCT with low mitotic rate. Furthermore, it was stage IA according to International Federation of Gynecology and Obstetrics. Laparoscopic right salpingo-oophorectomy was preformed, resulting in regression of virilization symptoms and normalization of serum testosterone and AFP levels. Conclusion − Due to rarity of SLCT in children and adolescents, gathering information from available case reports is necessary to establish guidelines regarding optimal management, including type of surgery and adjuvant chemotherapy. New knowledge regarding related diseases in SLCT survivors emphasize the need for long-term follow up of these patients.

Published
2018
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2. Incidence of type 1 diabetes mellitus in 0 to 14-yr-old children in Croatia - 2004 to 2012 study.

Author

Rojnic Putarek, Natasa, Ille, Jasenka, Spehar Uroic, Anita, Skrabic, Veselin, Stipancic, Gordana, Krnic, Nevena, Radica, Ana, Marjanac, Igor, Severinski, Srecko, Svigir, Alen, Bogdanic, Ana, and Dumic, Miroslav

Subjects
AGE distribution, CONFIDENCE intervals, PEOPLE with diabetes, PEDIATRICS, SEASONS, TYPE 1 diabetes, STATISTICS, DATA analysis, DIAGNOSIS, GENETICS
Abstract

Background The incidence of type 1 diabetes mellitus ( T1DM) among children and adolescents increased during the last 50 yr. The T1DM incidence in Croatia was 8.87/100.000/yr over 1995-2003, with an annual increase of 9%, which placed Croatia among countries with moderate risk for T1DM. Aim To investigate incidence rates and trends of T1DM from 2004 to 2012 in 0 to 14-yr-old Croatian children, and to compare the results with previous studies in Croatia and other European countries. Methods T1DM crude incidence rates are estimated for the entire group and three subgroups: 0-4, 5-9, and 10-14 yr. Standardized incidence is calculated using the method of direct standardization according to World Health Organization ( WHO) standard world population. The incidence rates by gender, age groups, seasonality, and calendar year, and their interactions were analyzed using Poisson regression model. Results A total of 1066 cases were ascertained over 2004-2012. The standardized incidence was 17.23/100.000/yr (95% CI: 16.19-18.26), with no significant differences in incidence rates or trends between boys and girls. Statistically significant annual increase of 5.87% (p < 0.001) was found for the whole group, and for the subgroups 5-9 yr (6.82%; p < 0.001) and 10-14 yr (7.47%; p < 0.001). In the youngest subgroup (0-4 yr), annual increase was lower (2.43%; p = 0338) and not statistically significant. Conclusion The incidence of childhood T1DM is increasing in Croatia, thus placing Croatia among countries with high risk for T1DM. The annual increment of 5.87% is considerably lower than 9.0% reported earlier, but still higher than the European average (3.9%). The increase in incidence ceased in youngest children. [ABSTRACT FROM AUTHOR]

Published
2015
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