1. External-beam radiotherapy in T1-2 N0 penile carcinoma.
- Author
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Azrif M, Logue JP, Swindell R, Cowan RA, Wylie JP, and Livsey JE
- Subjects
- Carcinoma, Squamous Cell surgery, Humans, Male, Neoplasm Recurrence, Local surgery, Penile Neoplasms surgery, Radiotherapy Dosage, Retrospective Studies, Survival, Treatment Outcome, Carcinoma, Squamous Cell radiotherapy, Neoplasm Recurrence, Local radiotherapy, Penile Neoplasms radiotherapy, Penis radiation effects
- Abstract
Aims: To review the outcome of 41 patients with invasive carcinoma of the penis treated with external-beam radiotherapy using a consistent technique and dose., Materials and Methods: Forty-one patients with carcinoma of the penis treated at Christie Hospital, Manchester, UK, between 1995 and 2000 were reviewed retrospectively. Radiotherapy was delivered using 4 MV linear accelerators with a dose of 50 Gy or 52.5 Gy in 16 fractions over 22 days., Results: The distribution of patients according to stage was T1=37, T2=4, N0=40, N3=1. Median follow-up was 4.5 years. The local control rate was 62%, nodal relapse-free rate of 88%, relapse-free rate of 51% and overall survival of 88% at 5 years. All recurrences were salvaged by surgery. Penile ulceration occurred in 8% and urethral stenosis requiring dilatation in 29%. There were no penectomies for penile necrosis., Conclusion: EBXRT may be offered for T1-2 cancer of the penis with close surveillance to detect local recurrences early for salvage surgery without jeopardising overall survival. It remains an alternative option to penis-preserving surgery and should be discussed in a multidisciplinary setting and with the patient.
- Published
- 2006
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