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Your search keyword '"Saheki MN"' showing total 2 results
Start Over Author "Saheki MN" Topic pentamidine
2 results on '"Saheki MN"'

1. Good response to pentamidine isethionate in a case of Mucosal Leishmaniasis caused by Leishmania (Viannia) braziliensis that was difficult to treat: Case Report.

Author

Ferreira Terceiro BR, Torraca TSS, Braga FPB, Martins ACDC, Brahim LR, Saheki MN, Miranda LFC, Schubach AO, and Valete-Rosalino CM

Subjects
Humans, Male, Middle Aged, Treatment Outcome, Antiprotozoal Agents therapeutic use, Leishmania braziliensis drug effects, Leishmaniasis, Mucocutaneous drug therapy, Pentamidine therapeutic use
Abstract

In Brazil, meglumine antimoniate is the first drug of choice for mucosal leishmaniasis treatment followed by amphotericin B and pentamidine isethionate. We report the case of a patient with severe mucosal lesions caused by Leishmania (Viannia) braziliensis that were difficult to treat. Over a 14-year period, the patient showed low adherence and three treatment attempts with meglumine antimoniate failed. Additionally, there was an unsatisfactory response to liposomal amphotericin B and nephrotoxicity when using amphotericin B deoxycholate that persisted after new treatment attempt with liposomal amphotericin B. Finally, healing was achieved with pentamidine isethionate and maintained during nine months of monitoring.

Published
2019
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2. American cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis resistant to meglumine antimoniate, but with good response to pentamidine: a case report.

Author

Pimentel MI, Baptista C, Rubin EF, Vasconcellos Ede C, Lyra MR, Salgueiro Mde M, Saheki MN, Rosalino CM, Madeira Mde F, Silva AF, Confort EM, and Schubach Ade O

Subjects
Adult, Humans, Leishmaniasis, Cutaneous drug therapy, Male, Meglumine Antimoniate, Parasitic Sensitivity Tests, Treatment Outcome, Antiprotozoal Agents therapeutic use, Leishmania braziliensis drug effects, Leishmaniasis, Cutaneous parasitology, Meglumine therapeutic use, Organometallic Compounds therapeutic use, Pentamidine therapeutic use
Abstract

This is a case report of a Brazilian soldier with cutaneous leishmaniasis. The lesion relapsed following two systemic treatments with meglumine antimoniate. The patient was treated with amphotericin B, which was interrupted due to poor tolerance. Following isolation of Leishmania sp., six intralesional infiltrations of meglumine antimoniate resulted in no response. Leishmania sp promastigotes were again isolated. The patient was submitted to intramuscular 4 mg/kg pentamidine. Parasites from the first and second biopsies were identified as Leishmania (Viannia) braziliensis; those isolated from the first biopsy were more sensitive to meglumine antimoniate in vitro than those isolated from the second biopsy. No relapse was observed.

Published
2011
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