1. Cyclols Revisited: Facile Synthesis of Medium-Sized Cyclic Peptides.
- Author
-
Mendoza-Sanchez R, Corless VB, Nguyen QNN, Bergeron-Brlek M, Frost J, Adachi S, Tantillo DJ, and Yudin AK
- Subjects
- Crystallography, X-Ray, Cyclization, Diketopiperazines chemistry, Imides chemistry, Isomerism, Molecular Conformation, Peptides, Cyclic chemical synthesis
- Abstract
Medium-sized rings, particularly the corresponding cyclic peptides, are challenging synthetic targets. In the present study, we report an approach to medium-sized cyclic peptides through targeted formation and collapse of cyclol intermediates. This methodology operates on β-amino imides derived from 2,5-diketopiperazines and offers a straightforward transition from frequently examined scaffolds in drug discovery to a rarely visited class of medium-sized rings., (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2017
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