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A study conducted by researchers at the General Hospital of Ningxia Medical University in China explores the anti-angiogenic effects of a fusion protein called BDS-hEA on hepatocellular carcinoma (HCC), a highly vascularized liver cancer. The researchers found that BDS-hEA induced autophagy in vascular endothelial cells, leading to a decrease in angiogenesis. They also discovered that BDS-hEA modulated the AMPK/AKT/mTOR signaling pathway, resulting in cytotoxic effects against HCC. These findings suggest that BDS-hEA has potential as a therapeutic approach for inhibiting angiogenesis in liver cancer. [Extracted from the article]

A new report from researchers at Carmel Medical Center in Haifa, Israel, explores the effects of tofacitinib, a JAK-STAT inhibitor used for rheumatoid arthritis (RA) treatment, on angiogenesis in RA. The study found that tofacitinib reduced levels of CD147 and matrix metalloproteinase-9 (MMP-9), which are pro-angiogenic factors, while increasing levels of endostatin, an anti-angiogenic factor. The researchers also discovered that tofacitinib inhibited cathepsin S activity, which is involved in endostatin degradation. These findings suggest that tofacitinib inhibits angiogenesis in RA through a dual effect mediated by CD147 and cathepsin S. [Extracted from the article]

A study conducted by researchers at Fujian Medical University Union Hospital in China analyzed the efficacy and safety of PD-1 inhibitors plus chemotherapy with or without endostatin for stage IV lung squamous cell carcinoma (LUSC). The study included 219 patients with stage IV LUSC, with some receiving PD-1 inhibitors plus chemotherapy with or without endostatin and others receiving chemotherapy with or without endostatin. The results showed that PD-1 inhibitors plus chemotherapy with endostatin may be a first-line treatment for patients with stage IV LUSC. The study also found that patients with certain characteristics had significant benefits from this treatment. [Extracted from the article]

A meta-analysis conducted by researchers at the Department of Oncology in Hubei, China, evaluated the efficacy and safety of recombinant human endostatin combined with vinorelbine + cisplatin (NPE) for the treatment of advanced non-small cell lung cancer (NSCLC). The study analyzed 24 randomized controlled trials with 2,114 patients and found that the NPE regimen significantly improved the total effective rate and clinical benefit rate of treatment compared to the NP regimen. However, there was no significant difference in adverse event rates between the two groups. The researchers recommend further prospective randomized trials to validate the safety and efficacy of this treatment approach. [Extracted from the article]

A study conducted at Shandong Provincial Qianfoshan Hospital in China investigated the efficacy and safety of continuous intravenous infusion of rh-endostatin, an antiangiogenic agent, combined with platinum-based doublet chemotherapy for advanced non-small cell lung cancer (NSCLC). The study enrolled 48 patients with advanced NSCLC who had not received prior treatment. The results showed that the combination treatment had a median progression-free survival of 6.5 months and a median overall survival of 12.3 months. The study also found a correlation between elevated serum carcinoembryonic antigen (CEA) levels and decreased progression-free survival and overall survival. The researchers concluded that the combination treatment was both safe and effective for advanced NSCLC. [Extracted from the article]

A preprint abstract from medrxiv.org discusses the potential use of plasma endostatin as a biomarker for predicting acute kidney injury (AKI) and the need for renal replacement therapy (RRT) in the intensive care unit (ICU). The study, which included 4449 admissions to four ICUs, found that endostatin was associated with AKI, future AKI, future AKI stage 3, and RRT, independently of creatinine and cystatin C. In patients with low to mildly elevated creatinine, endostatin outperformed creatinine and cystatin C in predicting future AKI. However, endostatin was not associated with 30-day mortality. This research has not yet undergone peer review. [Extracted from the article]

A new study conducted by researchers at the National Institutes for Food and Drug Control has provided findings on collagen type XVIII. The study focused on the biological activity of recombinant proteins, which are increasingly being used to treat human diseases. The researchers used gene-editing technology to identify potential endostatin-resistant genes and successfully constructed a highly sensitive cell line for detecting the biological activity of endostatin. The method was validated and produced consistent results with higher sensitivity and more stable data compared to traditional methods. This research provides a novel solution for assessing the biological activity of recombinant proteins. [Extracted from the article]

A recent study conducted by Lund University in Sweden has found a potential link between orthostatic hypotension (OH) and higher levels of circulating endostatin, an angiogenesis inhibitor. The study compared endostatin levels in 146 OH patients and 150 controls and found that endostatin levels were significantly higher in OH patients. The researchers suggest that circulating endostatin may serve as a clinical marker for increased cardiovascular risk in OH patients. However, further research is needed to validate these findings and understand the underlying mechanisms. [Extracted from the article]

Keywords: Adverse Drug Reactions; Angiostatic Proteins; Biomarkers; Cancer; Chemotherapy; Collagen Type XVIII; Diagnostics and Screening; Drugs and Therapies; Endostatins; Extracellular Matrix Proteins; Genetics; Health and Medicine; Intercellular Signaling Peptides and Proteins; Lung Cancer; Lung Diseases and Conditions; Lung Neoplasms; Non-Small Cell Lung Cancer; Oncology; Peptides; Scleroproteins EN Adverse Drug Reactions Angiostatic Proteins Biomarkers Cancer Chemotherapy Collagen Type XVIII Diagnostics and Screening Drugs and Therapies Endostatins Extracellular Matrix Proteins Genetics Health and Medicine Intercellular Signaling Peptides and Proteins Lung Cancer Lung Diseases and Conditions Lung Neoplasms Non-Small Cell Lung Cancer Oncology Peptides Scleroproteins 1626 1626 1 10/30/23 20231103 NES 231103 2023 OCT 31 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Research findings on non-small cell lung cancer are discussed in a new report. For more information on this research see: A real-world study of recombinant human endostatin combined with PD-1/PD-L1 blockade and chemotherapy for patients with advanced non-small cell lung cancer negative for actionable molecular biomarkers. [Extracted from the article]

Patients have signed the informed consent form and are willing and able to comply with the study plan visits, treatment plan, laboratory tests and other study procedures; Exclusion Criteria: Patients with recurrent nasopharyngeal carcinoma and distant metastasis. [Extracted from the article]

Keywords: Angiogenesis; Angiostatic Proteins; Cancer; Collagen Type XVIII; Endostatins; Extracellular Matrix Proteins; Health and Medicine; Hematology; Immunoproliferative Disorders; Intercellular Signaling Peptides and Proteins; Lymphatic Diseases and Conditions; Lymphoma; Lymphoproliferative Disorders; Non-Hodgkin Lymphoma; Oncology; Peptides; Scleroproteins EN Angiogenesis Angiostatic Proteins Cancer Collagen Type XVIII Endostatins Extracellular Matrix Proteins Health and Medicine Hematology Immunoproliferative Disorders Intercellular Signaling Peptides and Proteins Lymphatic Diseases and Conditions Lymphoma Lymphoproliferative Disorders Non-Hodgkin Lymphoma Oncology Peptides Scleroproteins 550 550 1 06/05/23 20230605 NES 230605 2023 JUN 5 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Investigators publish new report on non-hodgkin lymphoma. Angiogenesis, Angiostatic Proteins, Cancer, Collagen Type XVIII, Extracellular Matrix Proteins, Health and Medicine, Hematology, Immunoproliferative Disorders, Intercellular Signaling Peptides and Proteins, Lymphatic Diseases and Conditions, Lymphoma, Lymphoproliferative Disorders, Non-Hodgkin Lymphoma, Oncology, Peptides, Scleroproteins, Endostatins Keywords for this news article include: Uppsala University, Uppsala, Sweden, Europe, Cancer, Oncology, Hematology, Endostatins, Angiogenesis, Scleroproteins, Collagen Type XVIII, Health and Medicine, Angiostatic Proteins, Non-Hodgkin Lymphoma, Extracellular Matrix Proteins, Immunoproliferative Disorders, Lymphoproliferative Disorders, Lymphatic Diseases and Conditions. [Extracted from the article]

Keywords: Adenovirus; Angiostatic Proteins; Cancer; Collagen Type XVIII; DNA Viruses; Drugs and Therapies; Endostatins; Extracellular Matrix Proteins; Health and Medicine; Intercellular Signaling Peptides and Proteins; Oncology; Peptides; Scleroproteins; Therapy EN Adenovirus Angiostatic Proteins Cancer Collagen Type XVIII DNA Viruses Drugs and Therapies Endostatins Extracellular Matrix Proteins Health and Medicine Intercellular Signaling Peptides and Proteins Oncology Peptides Scleroproteins Therapy 309 309 1 05/29/23 20230530 NES 230530 2023 MAY 30 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Investigators publish new report on adenovirus. Adenovirus, Angiostatic Proteins, Cancer, Collagen Type XVIII, Drugs and Therapies, Endostatins, DNA Viruses, Extracellular Matrix Proteins, Health and Medicine, Intercellular Signaling Peptides and Proteins, Oncology, Peptides, Scleroproteins, Therapy. [Extracted from the article]

Angiostatic Proteins, Cancer, Carcinomas, Collagen Type XVIII, Drugs and Therapies, Extracellular Matrix Proteins, Genetics, Health and Medicine, Intercellular Signaling Peptides and Proteins, Nasopharyngeal Carcinoma, Oncology, Peptides, Scleroproteins, Endostatins Keywords for this news article include: First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China, Asia, Cancer, Genetics, Oncology, Endostatins, Scleroproteins, Collagen Type XVIII, Drugs and Therapies, Health and Medicine, Angiostatic Proteins, Nasopharyngeal Carcinoma, Extracellular Matrix Proteins, Intercellular Signaling Peptides and Proteins. Keywords: Angiostatic Proteins; Cancer; Carcinomas; Collagen Type XVIII; Drugs and Therapies; Endostatins; Extracellular Matrix Proteins; Genetics; Health and Medicine; Intercellular Signaling Peptides and Proteins; Nasopharyngeal Carcinoma; Oncology; Peptides; Scleroproteins EN Angiostatic Proteins Cancer Carcinomas Collagen Type XVIII Drugs and Therapies Endostatins Extracellular Matrix Proteins Genetics Health and Medicine Intercellular Signaling Peptides and Proteins Nasopharyngeal Carcinoma Oncology Peptides Scleroproteins 108 108 1 05/08/23 20230513 NES 230513 2023 MAY 8 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- Data detailed on nasopharyngeal carcinoma have been presented. [Extracted from the article]

Keywords: Harbin; People's Republic of China; Asia; Angiostatic Proteins; Cancer; Cancer Therapy; Collagen Type XVIII; Drugs and Therapies; Endostatins; Extracellular Matrix Proteins; Health and Medicine; Intercellular Signaling Peptides and Proteins; Oncology; Peptides; Prostate Cancer; Prostatic Neoplasms; Proteins; Proteomics; Scleroproteins; Therapy EN Harbin People's Republic of China Asia Angiostatic Proteins Cancer Cancer Therapy Collagen Type XVIII Drugs and Therapies Endostatins Extracellular Matrix Proteins Health and Medicine Intercellular Signaling Peptides and Proteins Oncology Peptides Prostate Cancer Prostatic Neoplasms Proteins Proteomics Scleroproteins Therapy 544 544 1 04/10/23 20230411 NES 230411 2023 APR 11 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- Investigators publish new report on Oncology - Prostate Cancer. According to news originating from Harbin, People's Republic of China, by NewsRx correspondents, research stated, "Prostate cancer (PCa) is the leading cause of death in men and has poor therapeutic outcomes. [Extracted from the article]

Keywords: Angiostatic Proteins; Cancer; Collagen Type XVIII; Drugs and Therapies; Endostatins; Extracellular Matrix Proteins; Genetics; Health and Medicine; Intercellular Signaling Peptides and Proteins; Lung Cancer; Lung Diseases and Conditions; Lung Neoplasms; Non-Small Cell Lung Cancer; Oncology; Peptides; Radiotherapy; Scleroproteins EN Angiostatic Proteins Cancer Collagen Type XVIII Drugs and Therapies Endostatins Extracellular Matrix Proteins Genetics Health and Medicine Intercellular Signaling Peptides and Proteins Lung Cancer Lung Diseases and Conditions Lung Neoplasms Non-Small Cell Lung Cancer Oncology Peptides Radiotherapy Scleroproteins 1172 1172 1 04/03/23 20230403 NES 230403 2023 APR 4 (NewsRx) -- By a News Reporter-Staff News Editor at Respiratory Therapeutics Week -- Investigators discuss new findings in non-small cell lung cancer. The Endostar group exhibited a numerically lower rate of radiation pneumonitis relapse, radiation pneumonitis death and pulmonary fibrosis.". [Extracted from the article]

Keywords: Angiostatic Proteins; Cancer; Cancer Therapy; Collagen Type XVIII; Drugs and Therapies; Endostatins; Extracellular Matrix Proteins; Health and Medicine; Intercellular Signaling Peptides and Proteins; Oncology; Peptides; Prostate Cancer; Prostatic Neoplasms; Proteins; Proteomics; Scleroproteins; Therapy EN Angiostatic Proteins Cancer Cancer Therapy Collagen Type XVIII Drugs and Therapies Endostatins Extracellular Matrix Proteins Health and Medicine Intercellular Signaling Peptides and Proteins Oncology Peptides Prostate Cancer Prostatic Neoplasms Proteins Proteomics Scleroproteins Therapy 771 771 1 03/27/23 20230328 NES 230328 2023 MAR 28 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- New research on prostate cancer is the subject of a new report. Angiostatic Proteins, Cancer, Cancer Therapy, Collagen Type XVIII, Drugs and Therapies, Endostatins, Extracellular Matrix Proteins, Health and Medicine, Intercellular Signaling Peptides and Proteins, Oncology, Peptides, Prostate Cancer, Prostatic Neoplasms, Proteins, Proteomics, Scleroproteins, Therapy. [Extracted from the article]

Keywords: Angiostatic Proteins; Cancer; Chemotherapy; Collagen Type XVIII; Drugs and Therapies; Endostatins; Extracellular Matrix Proteins; Genetics; Health and Medicine; Intercellular Signaling Peptides and Proteins; Oncology; Osteosarcomas; Peptides; Scleroproteins EN Angiostatic Proteins Cancer Chemotherapy Collagen Type XVIII Drugs and Therapies Endostatins Extracellular Matrix Proteins Genetics Health and Medicine Intercellular Signaling Peptides and Proteins Oncology Osteosarcomas Peptides Scleroproteins 286 286 1 03/23/23 20230324 NES 230324 2023 MAR 20 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on osteosarcomas. Angiostatic Proteins, Cancer, Chemotherapy, Collagen Type XVIII, Drugs and Therapies, Extracellular Matrix Proteins, Genetics, Health and Medicine, Intercellular Signaling Peptides and Proteins, Oncology, Osteosarcomas, Endostatins, Peptides, Scleroproteins. [Extracted from the article]

Angiogenesis, Angiogenic Proteins, Angiostatic Proteins, Antibodies, Biotechnology, Blood Proteins, Cancer, Cancer Therapy, Collagen Type XVIII, Drugs and Therapies, Endostatins, Extracellular Matrix Proteins, Growth Factor Receptors, Health and Medicine, Immunoglobulins, Immunology, Immunoproteins, Intercellular Signaling Peptides and Proteins, Membrane Proteins, Monoclonal Antibodies, Oncology, Peptides, Phosphotransferases, Protein Kinases, Proteins, Receptor Protein-Tyrosine Kinases, Scleroproteins, Serum Globulins, VEGF, Vascular Endothelial Growth Factors Keywords: Angiogenesis; Angiogenic Proteins; Angiostatic Proteins; Antibodies; Biotechnology; Blood Proteins; Cancer; Cancer Therapy; Collagen Type XVIII; Drugs and Therapies; Endostatins; Extracellular Matrix Proteins; Growth Factor Receptors; Health and Medicine; Immunoglobulins; Immunology; Immunoproteins; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Monoclonal Antibodies; Oncology; Peptides; Phosphotransferases; Protein Kinases; Proteins; Receptor Protein-Tyrosine Kinases; Scleroproteins; Serum Globulins; VEGF; Vascular Endothelial Growth Factors EN Angiogenesis Angiogenic Proteins Angiostatic Proteins Antibodies Biotechnology Blood Proteins Cancer Cancer Therapy Collagen Type XVIII Drugs and Therapies Endostatins Extracellular Matrix Proteins Growth Factor Receptors Health and Medicine Immunoglobulins Immunology Immunoproteins Intercellular Signaling Peptides and Proteins Membrane Proteins Monoclonal Antibodies Oncology Peptides Phosphotransferases Protein Kinases Proteins Receptor Protein-Tyrosine Kinases Scleroproteins Serum Globulins VEGF Vascular Endothelial Growth Factors 637 637 1 03/23/23 20230320 NES 230320 2023 MAR 21 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Investigators publish new report on cancer. [Extracted from the article]

Keywords: Angiostatic Proteins; Cancer; Chemotherapy; Collagen Type XVIII; Drugs and Therapies; Endostatins; Extracellular Matrix Proteins; Genetics; Health and Medicine; Intercellular Signaling Peptides and Proteins; Lung Cancer; Lung Diseases and Conditions; Lung Neoplasms; Non-Small Cell Lung Cancer; Oncology; Peptides; Scleroproteins EN Angiostatic Proteins Cancer Chemotherapy Collagen Type XVIII Drugs and Therapies Endostatins Extracellular Matrix Proteins Genetics Health and Medicine Intercellular Signaling Peptides and Proteins Lung Cancer Lung Diseases and Conditions Lung Neoplasms Non-Small Cell Lung Cancer Oncology Peptides Scleroproteins 1335 1335 1 03/24/23 20230228 NES 230228 2023 FEB 28 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Data detailed on non-small cell lung cancer have been presented. Angiostatic Proteins, Cancer, Chemotherapy, Collagen Type XVIII, Drugs and Therapies, Extracellular Matrix Proteins, Genetics, Health and Medicine, Intercellular Signaling Peptides and Proteins, Lung Cancer, Lung Diseases and Conditions, Lung Neoplasms, Non-Small Cell Lung Cancer, Oncology, Peptides, Scleroproteins, Endostatins. [Extracted from the article]

Keywords: Angiogenesis; Angiostatic Proteins; Cancer; Clinical Trials and Studies; Collagen Type XVIII; Drugs and Therapies; Endostatins; Extracellular Matrix Proteins; Genetics; Health and Medicine; Immunotherapy; Intercellular Signaling Peptides and Proteins; Lung Cancer; Lung Diseases and Conditions; Lung Neoplasms; Non-Small Cell Lung Cancer; Oncology; Peptides; Pre-Trial Research; Radiotherapy; Scleroproteins EN Angiogenesis Angiostatic Proteins Cancer Clinical Trials and Studies Collagen Type XVIII Drugs and Therapies Endostatins Extracellular Matrix Proteins Genetics Health and Medicine Immunotherapy Intercellular Signaling Peptides and Proteins Lung Cancer Lung Diseases and Conditions Lung Neoplasms Non-Small Cell Lung Cancer Oncology Peptides Pre-Trial Research Radiotherapy Scleroproteins 2023 FEB 21 (NewsRx) -- By a News Reporter-Staff News Editor at Immunotherapy Weekly -- Investigators discuss new findings in non-small cell lung cancer. According to news reporting originating from Cape Town, South Africa, by NewsRx correspondents, research stated, "Non-small cell lung cancer (NSCLC) is the most prevalent type of lung cancer, which is the leading cause of cancer-related deaths worldwide.". [Extracted from the article]

The article discusses research from the Catholic University of Korea which explored the role of RNA binding protein HuD in mediating crosstalk between beta TC6 cells and pancreatic islet endothelial MS1 cells by the regulation of endostatin and expression of Serpin E1 secretory proteins in a mouse model.