1. Real-World Clinical Performance of a Novolimus-Eluting Stent Versus a Sirolimus-Eluting Stent.
- Author
-
Chang CC, Sung WT, Lu YW, Chuang MJ, Lee YH, Tsai YL, Chou RH, Huang SS, and Huang PH
- Subjects
- Humans, Male, Female, Retrospective Studies, Aged, Treatment Outcome, Coronary Artery Disease therapy, Time Factors, Follow-Up Studies, Acute Coronary Syndrome therapy, Risk Factors, Middle Aged, Coronary Angiography, Macrolides, Drug-Eluting Stents, Sirolimus administration & dosage, Percutaneous Coronary Intervention methods, Percutaneous Coronary Intervention instrumentation, Prosthesis Design
- Abstract
Introduction: The DESyne novolimus-eluting coronary stent (NES) is a new-generation drug-eluting stent (DES) that is widely used, but clinical data are rarely reported for this stent. We compared the safety and effectiveness of the DESyne NES and the Orsiro bioresorbable polymer sirolimus-eluting stent (SES) in patients undergoing percutaneous coronary intervention (PCI)., Methods: This was a retrospective, single-center, observational study. Between July 2017 and December 2022, patients who presented with chronic or acute coronary syndrome undergoing PCI with DESyne NES or Orsiro SES were consecutively enrolled in the present study. The primary endpoint, major adverse cardiovascular event (MACE), was a composite of cardiovascular death, target-vessel myocardial infarction, or clinically driven target-lesion revascularization., Results: A total of 776 patients (age 68.8 ± 12.2; 75.9% male) undergoing PCI were included. Overall, 231 patients with 313 lesions received NES and 545 patients with 846 lesions received SES. During a follow-up duration of 784 ± 522 days, the primary endpoint occurred in 10 patients (4.3%) in the NES group and in 36 patients (6.6%) in the SES group. After multivariate adjustment, the risk of MACE did not significantly differ between groups (NES vs. SES, hazard ratio 0.74, 95% CI, 0.35-1.55, p = 0.425). The event rate of individual components of the primary endpoint was comparable between the two groups., Conclusions: Favorable and similar clinical outcomes were observed in patients undergoing PCI with either NES or SES in a medium-term follow-up duration. Future studies with adequately powered clinical endpoints are required for further evaluation., (© 2024 The Author(s). Clinical Cardiology published by Wiley Periodicals LLC.)
- Published
- 2024
- Full Text
- View/download PDF