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Introduction. Psychological stress is an important factor in the pathogenesis of the periodontal disease. It is therefore essential to determine the relationship between psychosomatic stress and periodontal disease. For the treatment of stress in patients with generalized periodontitis, a medicinal composition is proposed, for determining its antidisbiotic effect in the experimental substantiation of its periodontio-protective action. Aim. to determine the psychosomatic state of subjects, the influence of psychological stress on the periodontal tissue and the experimental substantiation of the antidisbiotic effect of drug composition for stress neutralization. Materials and methods. To study the subjective human responses to the effect of various environmental factors, a specially designed questionnaire is advisable to be used. Diagnosis of the anxiety level was made by a self-determination test including reactive and personal anxiety according to Spielberger. Adrenaline stress was followed on rats, by oral application of a gel with adrenalin in a 0.36 mg/kg dose, for 10 days. Lincomycin was introduced with drinking water in a dose of 60 mg/kg. The gel of adrenoblockers (zocson + nicergolin and sibason) was applied in a 0.6 mg/kg does. The activity of urease, lysozyme, elastase was determined in serum, and the degree of disbiosis was calculated according to Levitsky. Results and disscusions. The Spielberger test showed a moderate level of reactive anxiety among respondents - 34.72±2.45, and a high level of personal anxiety - 50.64±3.58. In patients with a high level of personal anxiety, a significantly higher prevalence of periodontal disease, especially generalized periodontitis, has been detected. Experimental studies have shown that gel adrenoblockers decrease urease activity, increase lysozyme levels, which leads to a significant reduction of disbiosis. Conclusions. A high level of personal anxiety - 50.64±3.58 - leads to a significant increase in the prevalence of periodontal diseases -- 95.09±6.7%, especially generalized periodontitis -- 88.72±6.5%. Oral application of a gel containing adrenoblockers had an antidisbiotic effect after modeling of the adrenaline stress by administration of adrenalin and lincomycin to animals. [ABSTRACT FROM AUTHOR]