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Your search keyword '"Okun M"' showing total 14 results
Start Over Author "Okun M" Topic peroxidases
14 results on '"Okun M"'

4. Oxidation of tyrosine to dopachrome by peroxidase isolated from murine melanoma.

Author

Okun MR, Schley L, Ziegelstein R, and Blair H

Subjects
Animals, Clone Cells metabolism, In Vitro Techniques, Melanins biosynthesis, Mice, Mice, Inbred C57BL, Neoplasms, Experimental metabolism, Peroxidase, Indolequinones, Indoles metabolism, Isoenzymes metabolism, Melanoma metabolism, Peroxidases metabolism, Quinones metabolism, Tyrosine metabolism
Abstract

Peroxidase, isolated from B16 mouse melanoma, converted tyrosine to dopachrome in the presence of either dopa or dihydroxyfumarate co-factor. A suspended homogenate of cloned, cultured B16 mouse melanoma cells also showed peroxidatic conversion of tyrosine to dopachrome in the presence of dihydroxyfumarate co-factor. The findings confirm previous histochemical, autoradiographic-histochemical, and EM-histochemical studies showing that melanoma peroxidase can convert tyrosine to melanin.

Published
1982

5. Purification of peroxidase by isoelectric focusing. Use of ultrastructural localization of immunoglobulins.

Author

Rule AH, Schaumburg-Lever G, Patel RP, Schmidt-Ullrich B, and Okun MR

Subjects
Horseradish Peroxidase isolation & purification, Hydrogen-Ion Concentration, Immunoenzyme Techniques, Lactoperoxidase isolation & purification, Methods, Microscopy, Electron, Immunoglobulins analysis, Isoelectric Focusing, Peroxidases isolation & purification
Published
1976
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6. Hydroxylation of tyrosine by plant peroxidase and mushroom tyrosinase, with and without hydrazine, to retard the oxidation of dopa.

Author

Patel RP and Okun MR

Subjects
Hydrazines pharmacology, Hydroxylation, Oxidation-Reduction, Catechol Oxidase metabolism, Dihydroxyphenylalanine biosynthesis, Horseradish Peroxidase metabolism, Monophenol Monooxygenase metabolism, Peroxidases metabolism, Tyrosine metabolism
Abstract

Tyrosine was oxidized to dopa by horseradish peroxidase and mushroom tyrosinase. The first step of hydroxylation of tyrosine in the synthesis of melanin was demonstrated by isolation of dopa from the reaction mixture using hydrazine as a selective retardant.

Published
1977

7. Histochemical studies of conversion of tyrosine and DOPA to melanin mediated by mammalian peroxidase.

Author

Okun M, Edelstein L, Or N, Hamada G, and Donnellan B

Subjects
Animals, Autoradiography, Catechol Oxidase metabolism, Chelating Agents, Dogs, Eosinophils metabolism, Guinea Pigs, Histocytochemistry, Humans, Mast Cells metabolism, Melanocytes metabolism, Mice, Microscopy, Electron, Rats, Thiocarbamates, Dihydroxyphenylalanine metabolism, Melanins biosynthesis, Peroxidases metabolism, Tyrosine metabolism
Published
1970
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8. The role of peroxidase vs. the role of tyrosinase in enzymatic conversion of tyrosine to melanin in melanocytes, mast cells and eosinophils.

Author

Okun MR, Edelstein LM, Or N, Hamada G, and Donnellan B

Subjects
Animals, Carbon Isotopes, Catechol Oxidase pharmacology, Dihydroxyphenylalanine pharmacology, Dogs, Eosinophils cytology, Guinea Pigs, Histocytochemistry, Humans, In Vitro Techniques, Mast Cells cytology, Melanocytes cytology, Melanocytes enzymology, Melanoma metabolism, Mice, Peroxidases pharmacology, Rats, Temperature, Thiocarbamates pharmacology, Catechol Oxidase metabolism, Chromatophores enzymology, Eosinophils enzymology, Mast Cells enzymology, Melanins biosynthesis, Peroxidases metabolism, Tyrosine metabolism
Published
1970
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11. HISTOGENESIS OF MELANOCYTES.

Author

OKUN MR

Subjects
Animals, Dogs, Mice, Rats, Cell Physiological Phenomena, Chromatophores, Dog Diseases, Electrons, Histocytochemistry, Keratosis, Lichen Planus, Mast Cells, Melanins, Melanocytes, Microscopy, Microscopy, Electron, Nevus, Nevus, Pigmented, Pathology, Peroxidases, Pigmentation Disorders, Skin Neoplasms, Urticaria Pigmentosa, Vitiligo
Published
1965

12. Subcellular demonstration of peroxidatic oxidation of tyrosine to melanin using dihydroxyfumarate as cofactor in mouse melanoma cells.

Author

Okun MR, Donnellan B, Patel RP, and Edelstein LM

Subjects
Amines, Animals, Biphenyl Compounds, Carbamates, Dihydroxyphenylalanine, Endoplasmic Reticulum metabolism, Golgi Apparatus metabolism, Hydrogen Peroxide, Melanoma enzymology, Mice, Microscopy, Electron, Neoplasm Transplantation, Neoplasms, Experimental metabolism, Oxidation-Reduction, Thiocarbamates, Fumarates metabolism, Melanins metabolism, Melanoma metabolism, Peroxidases metabolism, Tyrosine metabolism
Published
1973
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13. A revised concept of mammalian melanogenesis: the possible synergistic functions of aerobic dopa oxidase and peroxidase. A review.

Author

Okun MR, Edelstein LM, Patel RP, and Donnellan B

Subjects
Aerobiosis, Animals, Eosinophils enzymology, Histocytochemistry, Humans, Mast Cells enzymology, Melanoma enzymology, Mice, Monophenol Monooxygenase metabolism, Neutrophils enzymology, Peroxidases analysis, Plants enzymology, Tyrosine metabolism, Catechol Oxidase metabolism, Melanins biosynthesis, Melanocytes enzymology, Peroxidases metabolism
Published
1973

14. Histochemical differentiation of peroxidase-mediated from tyrosinase-mediated melanin formation in mammalian tissues. The biologic significance of peroxidase-mediated oxidation of tyrosine to malanin.

Author

Okun MR, Edelstein LM, Or N, Hamada G, Donnellan B, and Lever WF

Subjects
Animals, Autoradiography, Biphenyl Compounds, Carbon Isotopes, Catalase, Catechol Oxidase, Dihydroxyphenylalanine metabolism, Dogs, Eosinophils metabolism, Guinea Pigs, Humans, Indicators and Reagents, Mast Cells metabolism, Melanins biosynthesis, Melanocytes metabolism, Mice, Microscopy, Electron, Oxidation-Reduction, Rats, p-Dimethylaminoazobenzene, Biotransformation, Melanins metabolism, Peroxidases, Tyrosine metabolism
Published
1970
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