3 results on '"Martin Dakouo"'
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2. Genetic Evidence for Transboundary Circulation of Peste Des Petits Ruminants Across West Africa
- Author
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Kadidia Tounkara, Olivier Kwiatek, Mamadou Niang, Cheik Abou Kounta Sidibe, Amadou Sery, Martin Dakouo, Habib Salami, Modou Moustapha Lo, Aminata Ba, Mariame Diop, Ahmed Bezeid El Mamy, Ahmed Salem El Arbi, Yahya Barry, Ekaterina Isselmou, Habiboullah Habiboullah, Abdellahi Salem Lella, Baba Doumbia, Mohamed Baba Gueya, Joseph Savadogo, Lassina Ouattara, Germaine Minougou, Geneviève Libeau, and Arnaud Bataille
- Subjects
virus spread ,peste des petits ruminants ,phylogeny ,eradication ,morbillivirus ,small ruminant ,Veterinary medicine ,SF600-1100 - Abstract
Peste des Petits Ruminants (PPR) is a viral disease affecting predominantly small ruminants. Due to its transboundary nature, regional coordination of control strategies will be key to the success of the on-going PPR eradication campaign. Here, we aimed at exploring the extent of transboundary movement of PPR in West Africa using phylogenetic analyses based on partial viral gene sequences. We collected samples and obtained partial nucleoprotein gene sequence from PPR-infected small ruminants across countries within West Africa. This new sequence data was combined with publically available data from the region to perform phylogenetic analyses. A total of fifty-five sequences were obtained in a region still poorly sampled. Phylogenetic analyses showed that the majority of virus sequences obtained in this study were placed within genetic clusters regrouping samples from multiple West African countries. Some of these clusters contained samples from countries sharing borders. In other cases, clusters grouped samples from very distant countries. Our results suggest extensive and recurrent transboundary movements of PPR within West Africa, supporting the need for a regional coordinated strategy for PPR surveillance and control in the region. Simple phylogenetic analyses based on readily available data can provide information on PPR transboundary dynamics and, therefore, could contribute to improve control strategies. On-going and future projects dedicated to PPR should include extensive genetic characterization and phylogenetic analyses of circulating viral strains in their effort to support the campaign for global eradication of the disease.
- Published
- 2019
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3. Combining viral genetic and animal mobility network data to unravel peste des petits ruminants transmission dynamics in West Africa
- Author
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Arnaud, Bataille, Habib, Salami, Ismaila, Seck, Modou Moustapha, Lo, Aminata, Ba, Mariame, Diop, Baba, Sall, Coumba, Faye, Mbargou, Lo, Lanceï, Kaba, Youssouf, Sidime, Mohamed, Keyra, Alpha Oumar Sily, Diallo, Mamadou, Niang, Cheick Abou Kounta, Sidibe, Amadou, Sery, Martin, Dakouo, Ahmed Bezeid, El Mamy, Ahmed Salem, El Arbi, Yahya, Barry, Ekaterina, Isselmou, Habiboullah, Habiboullah, Abdellahi Salem, Lella, Baba, Doumbia, Mohamed Baba, Gueya, Caroline, Coste, Cécile, Squarzoni Diaw, Olivier, Kwiatek, Geneviève, Libeau, Andrea, Apolloni, Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département Systèmes Biologiques (Cirad-BIOS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Food and Agriculture Organization of the United Nations, Global Emergency Centre for Transboundary Animal Diseases (ECTAD), Laboratoire National d'Elevage et de Recherches Vétérinaires [Dakar] (LNERV), Institut Sénégalais de Recherches Agricoles [Dakar] (ISRA), Direction des Services Vétérinaires de Dakar, Institut Supérieur des Sciences et de Médecine Vétérinaire de Dalaba (ISSMV/D), Laboratoire Central Vétérinaire [Bamako, Mali], Office National de Recherche et de Développement de l’Elevage (ONARDEL), and Ar. B., O.K., H.S. and G.L. were supported by a grant from the European Commission Animal Health and Welfare European Research Area Network (https://ec.europa.eu/food/animals/health_en) for the IUEPPR Project 'Improved Understanding of Epidemiology of PPR', in the framework of ANIHWA 2013. Ar. B., O.K. and G.L. were supported by a grant (SI2.756606) from the European Commission Directorate General for Health and Food Safety awarded to the European Union Reference Laboratory for Peste des Petits Ruminants (EURL-PPR). Ar.B., A.A., M.M.L. were supported by the European Commission through the International Fund for Agricultural Development (grant number 2000002577) and the CGIAR research program on Livestock. We thank all donors who support the work of the CGIAR research program on Livestock through their contributions to the CGIAR trust fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
- Subjects
Phylogénie ,Heredity ,Genetic Linkage ,[SDV]Life Sciences [q-bio] ,Gene Identification and Analysis ,Genetic Networks ,L73 - Maladies des animaux ,Geographical Locations ,Peste des petits ruminants ,Biology (General) ,Génétique ,Data Management ,Mammals ,Goats ,Microbial Genetics ,Eukaryota ,Phylogenetic Analysis ,Ruminants ,Senegal ,Phylogenetics ,Africa, Western ,Veterinary Diseases ,[SDV.SA.SPA]Life Sciences [q-bio]/Agricultural sciences/Animal production studies ,Vertebrates ,L20 - Écologie animale ,Network Analysis ,Research Article ,Computer and Information Sciences ,QH301-705.5 ,Analyse de réseau ,Distribution des populations ,Peste-des-petits-ruminants virus ,Virus peste petits ruminants ,Virus des animaux ,Peste-des-Petits-Ruminants ,Genetics ,Animals ,Evolutionary Systematics ,Transmission des maladies ,Taxonomy ,Evolutionary Biology ,Sheep ,Organisms ,Migration animale ,Biology and Life Sciences ,RC581-607 ,People and Places ,Africa ,Amniotes ,Animal Migration ,Veterinary Science ,Immunologic diseases. Allergy ,Zoology - Abstract
Peste des petits ruminants (PPR) is a deadly viral disease that mainly affects small domestic ruminants. This disease threaten global food security and rural economy but its control is complicated notably because of extensive, poorly monitored animal movements in infected regions. Here we combined the largest PPR virus genetic and animal mobility network data ever collected in a single region to improve our understanding of PPR endemic transmission dynamics in West African countries. Phylogenetic analyses identified the presence of multiple PPRV genetic clades that may be considered as part of different transmission networks evolving in parallel in West Africa. A strong correlation was found between virus genetic distance and network-related distances. Viruses sampled within the same mobility communities are significantly more likely to belong to the same genetic clade. These results provide evidence for the importance of animal mobility in PPR transmission in the region. Some nodes of the network were associated with PPRV sequences belonging to different clades, representing potential “hotspots” for PPR circulation. Our results suggest that combining genetic and mobility network data could help identifying sites that are key for virus entrance and spread in specific areas. Such information could enhance our capacity to develop locally adapted control and surveillance strategies, using among other risk factors, information on animal mobility., Author summary As animals move so do viruses. The viral disease peste des petits ruminants (PPR) has a major impact on the livelihood of sheep and goat farmers across Africa, Middle-East and Asia. A global PPR eradication campaign is underway, but extensive movements of infected animals impede control efforts in many regions, such as West Africa. Here we show for the first time that PPR virus genetic data can be combined with information on animal mobility to identify routes of PPR circulation in Senegal and neighbouring countries. Such information can be used to design more efficient disease surveillance and control strategies adapted to local livestock farming practices.
- Published
- 2021
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